Science | Nature | Cell | View More
Natural Products
Alloimperatorin
Alloimperatorin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Alloimperatorin
Price: $298 / 10mg
CAS No.: 642-05-7
Catalog No.: CFN93037
Molecular Formula: C16H14O4
Molecular Weight: 270.28 g/mol
Purity: >=98%
Type of Compound: Coumarins
Physical Desc.: Powder
Source: The herbs of Angelica dahurica
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $99.2 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Ain Shams University (Egypt)
  • University of Hertfordshire (United Kingdom)
  • Celltrion Chemical Research Ins... (Korea)
  • Seoul National University of Sc... (Korea)
  • University of British Columbia (Canada)
  • Institute of Bioorganic Chemist... (Poland)
  • Universidade da Beira Interior (Germany)
  • Leibniz-Institut für Pflanzenb... (Germany)
  • Universidade Católica Portuguesa (Portugal)
  • National Cancer Institute (USA)
  • University of Toronto (Canada)
  • More...
Package
Featured Products
Isorhoifolin

Catalog No: CFN98927
CAS No: 552-57-8
Price: $318/10mg
Oxypaeoniflorin

Catalog No: CFN99589
CAS No: 39011-91-1
Price: $138/20mg
Decursin

Catalog No: CFN98509
CAS No: 5928-25-6
Price: $138/20mg
Kukoamine B

Catalog No: CFN93216
CAS No: 164991-67-7
Price: $268/10mg
2'-Acetylacteoside

Catalog No: CFN92452
CAS No: 94492-24-7
Price: $188/20mg
L-Nicotine

Catalog No: CFN99512
CAS No: 54-11-5
Price: $40/20mg
Soyasapogenol C

Catalog No: CFN91068
CAS No: 595-14-2
Price: $463/5mg
Cyclo(Pro-Val)

Catalog No: CFN90275
CAS No: 5654-87-5
Price: $238/10mg
Falcarinol

Catalog No: CFN96027
CAS No: 21852-80-2
Price: $218/20mg
Geniposidic acid

Catalog No: CFN98337
CAS No: 27741-01-1
Price: $30/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Alloimperatorin exhibits in vitro antitumor activity in HL-60 acute myeloid leukemia cancer cells via inducing apoptosis, cell cycle disruption and inhibition of cell migration. It photosensitizes efficiently the hemolysis of erythrocytes.
In vitro:
Bangladesh Journal of Pharmacology, 2016, 11(1):194.
Alloimperatorin and its epoxide derivative exhibit in vitro antitumor activity in HL-60 acute myeloid leukemia cancer cells via inducing apoptosis, cell cycle disruption and inhibition of cell migration[Reference: WebLink]
The aim of the present study was to synthesize epoxide derivative of Alloimperatorin and evaluating its antitumor and apoptotic effects in acute myeloid leukemia HL-60 cells.
METHODS AND RESULTS:
The cytotoxic effects were demonstrated by MTT assay. Fluorescence microscopy along with flow cytometry were performed to evaluate the effect of Alloimperatorin epoxide on apoptosis and cell cycle. In vitro wound healing assay was performed to study compounds effect on cancer cell migration.
METHODS AND RESULTS:
The results indicated that Alloimperatorin epoxide (IC50 = 32.1 μM) was much more effective in inhibiting HL-60 cancer cell growth as compared to Alloimperatorin (IC50 = 128 μM). Further, Alloimperatorin epoxide induced apoptosis related morphological alterations in HL-60 cells including blebbing of plasma membrane, DNA fragmentation and formation of apoptotic bodies. Alloimperatorin epoxide also led to G2/M phase cell cycle arrest and suppressed HL-60 cancer cell migration indicating that this compound may be a promising candidate for the treatment of cancer metastasis.
Photochemistry & Photobiology, 2014, 90(1):162-170.
Photohemolysis Sensitized by the Furocoumarin Derivative Alloimperatorin and its Hydroperoxide Photooxidation Product.[Pubmed: 24117477]

METHODS AND RESULTS:
The dark and photosensitized effects of Alloimperatorin methyl ether 1 (hereafter simply Alloimperatorin) and its photooxygenation product Alloimperatorin hydroperoxide 2 were investigated on human erythrocytes. The results reveal that the furocoumarin 1 photosensitizes efficiently the hemolysis of erythrocytes. The rate of photohemolysis increases on raising the temperature of the postirradiated incubation from 4°C to 37°C. Thermal activation of the photohemolysis and inhibition by 2,6-di-tert-butyl-p-cresol (BHT) suggest that the furocoumarin 1 photosensitizes lipid peroxidation, increasing permeability in the erythrocyte membrane. The hydroperoxide 2 induces dark and photosensitized hemolysis more efficiently than the furocoumarin 1. The rate of hemolysis induced by 2 increases with the incubation temperature and decreases in the presence of tert-butanol and BHT. The hydroperoxide 2 photosensitizes the formation of lipid peroxidation products as shown by the reaction with thiobarbituric acid. This process is diminished by BHT.
CONCLUSIONS:
Our data imply that the photohemolysis sensitized by the furocoumarin 1 is caused by the in situ-formed photooxygenation product 2. Such hydroperoxides are potent hemolytic agents in the dark and especially on photosensitization.
Alloimperatorin Description
Source: The herbs of Angelica dahurica
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Cuneataside C

Catalog No: CFN95368
CAS No: 871720-16-0
Price: $318/10mg
10-O-trans-p-Feruloylscandoside

Catalog No: CFN95392
CAS No: 1428268-72-7
Price: $318/10mg
Baishouwubenzophenone

Catalog No: CFN95473
CAS No: 115834-34-9
Price: $318/5mg
Silybin A

Catalog No: CFN95149
CAS No: 22888-70-6
Price: $318/20mg
Maculosidin

Catalog No: CFN95126
CAS No: 522-19-0
Price: $413/5mg
15-Methoxy-16-oxo-15,16H-strictic ...

Catalog No: CFN95261
CAS No: 1356388-38-9
Price: $368/5mg
Momordicine II

Catalog No: CFN95167
CAS No: 91590-75-9
Price: $318/10mg
Neoarctin B

Catalog No: CFN95243
CAS No: 155969-67-8
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.6999 mL 18.4993 mL 36.9987 mL 73.9973 mL 92.4967 mL
5 mM 0.74 mL 3.6999 mL 7.3997 mL 14.7995 mL 18.4993 mL
10 mM 0.37 mL 1.8499 mL 3.6999 mL 7.3997 mL 9.2497 mL
50 mM 0.074 mL 0.37 mL 0.74 mL 1.4799 mL 1.8499 mL
100 mM 0.037 mL 0.185 mL 0.37 mL 0.74 mL 0.925 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Isorhoifolin

Catalog No: CFN98927
CAS No: 552-57-8
Price: $318/10mg
Oxypaeoniflorin

Catalog No: CFN99589
CAS No: 39011-91-1
Price: $138/20mg
Decursin

Catalog No: CFN98509
CAS No: 5928-25-6
Price: $138/20mg
Kukoamine B

Catalog No: CFN93216
CAS No: 164991-67-7
Price: $268/10mg
2'-Acetylacteoside

Catalog No: CFN92452
CAS No: 94492-24-7
Price: $188/20mg
L-Nicotine

Catalog No: CFN99512
CAS No: 54-11-5
Price: $40/20mg
Soyasapogenol C

Catalog No: CFN91068
CAS No: 595-14-2
Price: $463/5mg
Cyclo(Pro-Val)

Catalog No: CFN90275
CAS No: 5654-87-5
Price: $238/10mg
Falcarinol

Catalog No: CFN96027
CAS No: 21852-80-2
Price: $218/20mg
Geniposidic acid

Catalog No: CFN98337
CAS No: 27741-01-1
Price: $30/20mg
Tags: buy Alloimperatorin | Alloimperatorin supplier | purchase Alloimperatorin | Alloimperatorin cost | Alloimperatorin manufacturer | order Alloimperatorin | Alloimperatorin distributor