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Atractyloside A
Atractyloside A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Atractyloside A
Price: $268 / 20mg
CAS No.: 126054-77-1
Catalog No.: CFN98560
Molecular Formula: C21H36O10
Molecular Weight: 448.5 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Powder
Source: The roots of Atractylodes lancea (Thunb.) DC.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / $83.7 / In-stock
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Atractyloside is a toxic compound from wedelia glauca. It acts as inhibitor of oxidative phosphorylation by a specific interference with energy-transfer reactions, the effect is due to inhibition of the ADP utilizing process in the coupling system. Atractyloside, has been proposed for the antibiotic oligomycin, is an inhibitor of the energy-transfer reactions in animal mitochondria; it inhibits the phosphate uptake and the respiratory stimulation induced by P1-acceptor, but it does not interfere with the so-called resting respiration.
Atractyloside A Description
Source: The roots of Atractylodes lancea (Thunb.) DC.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2297 mL 11.1483 mL 22.2965 mL 44.5931 mL 55.7414 mL
5 mM 0.4459 mL 2.2297 mL 4.4593 mL 8.9186 mL 11.1483 mL
10 mM 0.223 mL 1.1148 mL 2.2297 mL 4.4593 mL 5.5741 mL
50 mM 0.0446 mL 0.223 mL 0.4459 mL 0.8919 mL 1.1148 mL
100 mM 0.0223 mL 0.1115 mL 0.223 mL 0.4459 mL 0.5574 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chinese journal of pharmaceutical analysis, 2014.
Determination of atractyloside A in raw and bran fried rhizome of Atractylodes lancea by HPLC-ELSD.[Reference: WebLink]
To establish a method for determination of the content of Atractyloside A in rhizome of Atractylodes lancea and compare the content of Atractyloside A in raw and bran fried rhizome of Atractylodes lancea.
METHODS AND RESULTS:
:The HPLCESLD was carried out on an analytical C18column( Agilent TCC18,4.6 mm ×250 mm,5μm) at a column temperature of 30 ℃ and a flow rate of 1. 0 mL·min1. The mobile phase was gradient elution( 010 min,2% A→8% A; 1015 min,8% A→15% A; after 15 min,15% A) with mixture liquid of acetonitrile( A)and water( B). The drift tube temperature for the ELSD was set at 50 ℃ with the nebulizing gas( nitrogen) pressure of 3. 0 × 105 Pa. The calibration curve of Atractyloside A was linear in the ranges of 0. 23904. 7800 μg( r =0.9998). The average recovery of the method for Atractyloside A was97.84%with RSD1.0%. The sample determination result was 0. 0474%0. 0852%.
CONCLUSIONS:
After the methodology validation,this method can provide the experimental basis for the quality control of rhizome of Atractylodes lancea.
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