Baicalein 7-O-beta-D-ethylglucuronide | CAS:675624-38-1

Baicalein 7-O-beta-D-ethylglucuronide

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Description:

Baicalein 7-O-beta-D-ethylglucuronide is a natural product from Scutellaria baicalensis Georgi.

In vitro:

Nat Prod Res. 2014;28(20):1772-6.

A new antioxidant flavone glycoside from Scutellaria baicalensis Georgi.[Pubmed: 24995563 ]

METHODS AND RESULTS:
A new flavone glycoside, wogonin 7-O-β-D-ethylglucuronide (1), together with a new natural flavone glycoside baicalein 7-O-β-D-ethylglucuronide (Baicalein 7-O-beta-D-ethylglucuronide,2) and four known analogues, wogonoside (3), wogonin (4), oroxylin A 7-O-β-D-methylglucuronide (5) and oroxylin A (6), was isolated from the roots of Scutellaria baicalensis Georgi. The structure elucidation of the new compound was primarily based on HR-ESI-MS, 1D and 2D NMR analyses.
CONCLUSIONS:
Compounds 1 and 3 inhibited FeSO4-Cys-induced liver homogenate lipid peroxidation with IC50 at 18.2 μM and 24.9 μM, respectively, and exhibited strong cytoprotective effects against H2O2-induced oxidative damage in human umbilical vein endothelial cells at low concentrations of 10.0 μM and 3.0 μM.

In vivo:

Journal of Applied Pharmaceutical Science, 2013, 3(12):46-51.

Evaluation of wound healing activity of baicalein-7-O- β-Dglucuronide isolated from Leucas aspera[Reference: WebLink]

Leucas aspera (Willd.) Linn. (Lamiaceae), commonly known as "Thumbai," is distributed throughout India. This study includes the isolation and characterization of flavonoids present in Leucas aspera flowers were compared wound healing activity with standard soframycin ointment.
METHODS AND RESULTS:
The plant materials were extracted with 95% methanol, petroleum ether, ethyl acetate, and were subjected to column and TLC chromatographic separation analysis. The chemical constituents isolated from the flowers of L. aspera were characterized based on chemical tests and spectral analysis such as UV and NMR spectroscopy. The structure of the isolated compound was confirmed as baicalein-7-O- β-D-glucuronide (baicalin). It has been investigated for wound healing activity by applying on the albino rats. A slow rate of healing was observed earlier which turns to very rapid on the 12th day. The histopathological examination provided additional evidence for the experimental wound healing studies. Protease is a biochemical marker and pH measured to support the wound healing activity.
CONCLUSIONS:
We conclude that the baicalin isolated with the flowers of L. aspera has better wound healing activity.

Baicalein 7-O-beta-D-ethylglucuronide Description

Source:	The roots of Scutellaria baicalensis Georgi
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Baicalein 7-O-beta-D-ethylglucuronide
Price:
CAS No.:	675624-38-1
Catalog No.:	CFN91993
Molecular Formula:	C₂₃H₂₂O₁₁
Molecular Weight:	474.41 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The roots of Scutellaria baicalensis Georgi
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1079 mL	10.5394 mL	21.0788 mL	42.1576 mL	52.697 mL
5 mM	0.4216 mL	2.1079 mL	4.2158 mL	8.4315 mL	10.5394 mL
10 mM	0.2108 mL	1.0539 mL	2.1079 mL	4.2158 mL	5.2697 mL
50 mM	0.0422 mL	0.2108 mL	0.4216 mL	0.8432 mL	1.0539 mL
100 mM	0.0211 mL	0.1054 mL	0.2108 mL	0.4216 mL	0.527 mL

CFN90833	Chrysin 7-O-beta-gentiobioside	88640-89-5	578.5	C₂₇H₃₀O₁₄
CFN99712	Oroxin A	57396-78-8	432.38	C₂₁H₂₀O₁₀
CFN99111	Baicalin	21967-41-9	446.37	C₂₁H₁₈O₁₁
CFN92283	Baicalin methyl ester	82475-03-4	460.4	C₂₂H₂₀O₁₁
CFN91993	Baicalein 7-O-beta-D-ethylglucuronide	675624-38-1	474.41	C₂₃H₂₂O₁₁
CFN92361	Baicalein 6-O-glucoside	28279-72-3	432.4	C₂₁H₂₀O₁₀
CFN99713	Oroxin B	114482-86-9	594.52	C₂₇H₃₀O₁₅
CFN90191	Oroxylin A 7-O-beta-D-glucuronide	36948-76-2	460.39	C₂₂H₂₀O₁₁
CFN92282	Oroxylin A 7-O-beta-D-glucuronide methyl ester	82475-01-2	474.4	C₂₃H₂₂O₁₁
CFN92280	Glychionide A	119152-50-0	446.4	C₂₁H₁₈O₁₁