Bisandrographolide A | CAS:160498-00-0

Bisandrographolide A

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Description:

Bisandrographolide A activates TRPV4 channels, could play a role in some of the effects of Andrographis extract described in traditional medicine.

Targets:

TRPV

In vitro:

J Biol Chem. 2006 Oct 6;281(40):29897-904.

Bisandrographolide from Andrographis paniculata activates TRPV4 channels.[Pubmed: 16899456]

Many transient receptor potential (TRP) channels are activated or blocked by various compounds found in plants; two prominent examples include the activation of TRPV1 channels by capsaicin and the activation of TRPM8 channels by menthol.
METHODS AND RESULTS:
We sought to identify additional plant compounds that are active on other types of TRP channels. We screened a library of extracts from 50 Chinese herbal plants using a calcium-imaging assay to find compounds active on TRPV3 and TRPV4 channels. An extract from the plant Andrographis paniculata potently activated TRPV4 channels. The extract was fractionated further, and the active compound was identified as Bisandrographolide A (BAA). We used purified compound to characterize the activity of Bisandrographolide A on certain TRPV channel subtypes. Although Bisandrographolide A activated TRPV4 channels with an EC(50) of 790-950 nm, it did not activate or block activation of TRPV1, TRPV2, or TRPV3 channels. Bisandrographolide A activated a large TRPV4-like current in immortalized mouse keratinocytes (308 cells) that have been shown to express TRPV4 protein endogenously. This compound also activated TRPV4 currents in cell-free outside-out patches from HEK293T cells overexpressing TRPV4 cDNA, suggesting that Bisandrographolide A can activate the channel in a membrane-delimited manner. Another related compound, andrographolide, found in abundance in the plant Andrographis was unable to activate or block activation of TRPV4 channels.
CONCLUSIONS:
These experiments show that Bisandrographolide A activates TRPV4 channels, and we discuss the possibility that activation of TRPV4 by Bisandrographolide A could play a role in some of the effects of Andrographis extract described in traditional medicine.

Bisandrographolide A Description

Source:	The herbs of Andrographis paniculata (Burm. f.) Nees
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Bisandrographolide A
Price:
CAS No.:	160498-00-0
Catalog No.:	CFN97814
Molecular Formula:	C₄₀H₅₆O₈
Molecular Weight:	664.88 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The herbs of Andrographis paniculata (Burm. f.) Nees
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Activators Compound Library Diterpenoids Compound Library TRPV Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.504 mL	7.5202 mL	15.0403 mL	30.0806 mL	37.6008 mL
5 mM	0.3008 mL	1.504 mL	3.0081 mL	6.0161 mL	7.5202 mL
10 mM	0.1504 mL	0.752 mL	1.504 mL	3.0081 mL	3.7601 mL
50 mM	0.0301 mL	0.1504 mL	0.3008 mL	0.6016 mL	0.752 mL
100 mM	0.015 mL	0.0752 mL	0.1504 mL	0.3008 mL	0.376 mL

CFN97766	Neoandrographolide	27215-14-1	480.60	C₂₆H₄₀O₈
CFN97671	Andropanoside	82209-72-1	496.60	C₂₆H₄₀O₉
CFN97822	14-Deoxy-11,12-didehydroandrographiside	141973-41-3	494.58	C₂₆H₃₈O₉
CFN97670	Andrographiside	82209-76-5	512.60	C₂₆H₄₀O₁₀
CFN97813	Bisandrographolide C	160498-02-2	664.88	C₄₀H₅₆O₈
CFN97814	Bisandrographolide A	160498-00-0	664.88	C₄₀H₅₆O₈