Bruceine J | CAS:948038-38-8 | Manufacturer ChemFaces

Bruceine J

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Description:

Reference standards.

In vitro:

J Nat Prod. 2007 Oct;70(10):1654-7.

Screening of Indonesian medicinal plant extracts for antibabesial activity and isolation of new quassinoids from Brucea javanica.[Pubmed: 17896817 ]

Boiled extracts derived from 28 Indonesian medicinal plants were screened for their antibabesial activity against Babesia gibsoni in vitro.
METHODS AND RESULTS:
Of these extracts, the fruit of Brucea javanica was the most active in inhibiting parasite growth at a concentration of 10 microg/mL. Bioassay-guided fractionation of the fruit extract of Br. javanica led to the isolation of two new quassinoids, bruceantinol B and Bruceine J, and the structures of these compounds were elucidated on the basis of their spectroscopic data and by chemical transformation to known compounds. In addition, the known quassinoids bruceines A-D, bruceantinol, and yadanziolide A were isolated.
CONCLUSIONS:
Antibabesial activities were also examined in vitro, and bruceine A and bruceantinol were shown to be more potent than diminazene aceturate, a drug (IC50 = 103 ng/mL) used clinically against B. gibsoni, with IC50 values of 4 and 12 ng/mL, respectively.

Bruceine J Description

Source:	The fruits of Brucea javanica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Bruceine J
Price:
CAS No.:	948038-38-8
Catalog No.:	CFN91973
Molecular Formula:	C₂₅H₃₂O₁₁
Molecular Weight:	508.51 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The fruits of Brucea javanica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9665 mL	9.8326 mL	19.6653 mL	39.3306 mL	49.1632 mL
5 mM	0.3933 mL	1.9665 mL	3.9331 mL	7.8661 mL	9.8326 mL
10 mM	0.1967 mL	0.9833 mL	1.9665 mL	3.9331 mL	4.9163 mL
50 mM	0.0393 mL	0.1967 mL	0.3933 mL	0.7866 mL	0.9833 mL
100 mM	0.0197 mL	0.0983 mL	0.1967 mL	0.3933 mL	0.4916 mL

CFN96421	Yadanzioside I	99132-95-3	642.60	C₂₉H₃₈O₁₆
CFN96417	Yadanzioside P	79439-84-2	710.72	C₃₄H₄₆O₁₆
CFN96419	Yadanzioside L	99132-97-5	726.72	C₃₄H₄₆O₁₇
CFN96420	Yadanzioside K	101559-98-2	768.76	C₃₆H₄₈O₁₈
CFN92980	13,18-Dehydroglaucarubinone	68703-94-6	492.52	C₂₅H₃₂O₁₀
CFN92979	(+)-Glaucarubinone	1259-86-5	494.53	C₂₅H₃₄O₁₀
CFN89335	Bruceine B	25514-29-8	480.46	C₂₃H₂₈O₁₁
CFN91974	Bruceine C	25514-30-1	564.58	C₂₈H₃₆O₁₂
CFN89336	Bruceantinol	53729-52-5	606.62	C₃₀H₃₈O₁₃
CFN95216	Bruceantinol B	1822332-33-1	550.6	C₂₇H₃₄O₁₂