Byzantionoside B | CAS:189109-45-3 | Manufacturer ChemFaces

Byzantionoside B

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Description:

Byzantionoside B shows stimulatory activity on human osteoblast cells, it may have the potential to stimulate bone formation and regeneration.

In vitro:

J Agric Food Chem. 2014 Jun 18;62(24):5581-8.

Stimulation of osteogenic activity in human osteoblast cells by edible Uraria crinita.[Pubmed: 24785825]

Uraria crinita is an edible herb used as a natural food for childhood skeletal dysplasia.
METHODS AND RESULTS:
Ethyl acetate, n-butanol, and aqueous fractions of a 95% ethanol crude extract of U. crinita were obtained and the active ingredients isolated and purified using a bioguided method. In this manner, we isolated and identified a new active flavone glycoside, apigenin 6-C-β-d-apiofuranosyl(1→2)-α-d-xylopyranoside (3) and 10 known components with stimulatory activity on human osteoblast cells. The new compound 3 at 100 μM significantly increased alkaline phosphatase activity (114.10 ± 4.41%), mineralization (150.10 ± 0.80%), as well as osteopontin (1.39 ± 0.01-fold), bone morphogenetic protein-2 (BMP-2, 1.30 ± 0.04-fold), and runt-related transcription factor 2 (Runx2, 1.43 ± 0.10-fold) mRNA expression through the activation of the BMP-2/Runx2 pathway. Two other components, dalbergioidin (1) and Byzantionoside B (9), displayed similar effects.
CONCLUSIONS:
These results show that U. crinita and its active compounds may have the potential to stimulate bone formation and regeneration.

Byzantionoside B Description

Source:	The herbs of Uraria crinita
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Chem Pharm Bull (Tokyo). 2010 Mar;58(3):438-41.

Structural revisions of blumenol C glucoside and byzantionoside B.[Pubmed: 20190461]

METHODS AND RESULTS:
The absolute stereochemistry of blumenol C glucoside and Byzantionoside B was revised here as (6R,9S)- and (6R,9R)-9-hydroxymegastigman-4-en-3-one 9-O-beta-D-glucopyranosides, respectively, by modified Mosher's method. The empirical rules of (13)C-NMR chemical shift to determine the absolute stereochemistry of C-9 of 9-hydroxymegastigmane 9-O-beta-D-glucopyranoside were also discussed.

Zhongguo Zhong Yao Za Zhi. 2012 May;37(10):1417-21.

[Chemical constituents from the seed coat of Juglans regia].[Pubmed: 22860453]

METHODS AND RESULTS:
Fifteen compounds were isolated from the seed coat of Juglans regia by silica gel, MCI gel and Sephadex LH-20 gel column chromatography, as well as high preparative performance liquid chromatography.
CONCLUSIONS:
Their structures were identified as salidroside (1), (6S, 9S)-roseoside (2), (6S, 9R)-roseoside (3), blumenol C glucoside (4), Byzantionoside B (5), 5-hydroxy-2-methoxy-1, 4-naphthoquinone (6), gallic acid (7), glycerol 1-(9Z-octadecenoate)-2-(9Z, 12Z-octadecadienoate)-3-(9Z, 12Z, 15Z-octadecatrienoate) (8), glycerol 1, 2, 3-tri-(9Z, 12Z-octadecadienoate) (9), glycerol 1, 2, 3-tri-(9Z, 12Z, 15Z-octadecatrienoate) (10), glycerol 1-hexadecanoate-2, 3-di-(9Z, 12Z-octadecadienoate) (11) on the basis of EI-MS, FAB-MS and NMR spectra. Moreover, 35 volatile compounds were identified by GC-MS.

Product Name	Byzantionoside B
Price:
CAS No.:	189109-45-3
Catalog No.:	CFN99871
Molecular Formula:	C₁₉H₃₂O₇
Molecular Weight:	372.5 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	The herbs of Uraria crinita
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Pro-osteoblastogenesis Compound Library Sesquiterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.6846 mL	13.4228 mL	26.8456 mL	53.6913 mL	67.1141 mL
5 mM	0.5369 mL	2.6846 mL	5.3691 mL	10.7383 mL	13.4228 mL
10 mM	0.2685 mL	1.3423 mL	2.6846 mL	5.3691 mL	6.7114 mL
50 mM	0.0537 mL	0.2685 mL	0.5369 mL	1.0738 mL	1.3423 mL
100 mM	0.0268 mL	0.1342 mL	0.2685 mL	0.5369 mL	0.6711 mL

CFN89279	Dehydrovomifoliol	39763-33-2	222.28	C₁₃H₁₈O₃
CFN89022	Boscialin	129277-03-8	226.31	C₁₃H₂₂O₃
CFN89291	Glochidionionol C	N/A	224.30	C₁₃H₂₀O₃
CFN98245	Vomifoliol	23526-45-6	224.3	C₁₃H₂₀O₃
CFN98916	Roseoside	54835-70-0	386.4	C₁₉H₃₀O₈
CFN99877	Corchoionol C	189351-15-3	224.3	C₁₃H₂₀O₃
CFN99859	Corchoionoside C	185414-25-9	386.4	C₁₉H₃₀O₈
CFN90997	7-Z-Trifostigmanoside I	1018898-17-3	518.55	C₂₄H₃₈O₁₂
CFN98232	9-Epiblumenol B	22841-42-5	226.3	C₁₃H₂₂O₃
CFN99424	Blumenol C glucoside	135820-80-3	372.5	C₁₉H₃₂O₇