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    Caffeine
    Information
    CAS No. 58-08-2 Price $50 / 20mg
    Catalog No.CFN99004Purity>=98%
    Molecular Weight194.2 Type of CompoundAlkaloids
    FormulaC8H10N4O2Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)
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    Caffeine Description
    Source: The seeds of Theobroma cacao L.
    Biological Activity or Inhibitors: 1. Caffeine has anxiolytic-like activity, can have both positive and negative effects on anxiety.
    2. Caffeine inhibits glucose transport by binding at the GLUT1 nucleotide-binding site.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.1493 mL 25.7467 mL 51.4933 mL 102.9866 mL 128.7333 mL
    5 mM 1.0299 mL 5.1493 mL 10.2987 mL 20.5973 mL 25.7467 mL
    10 mM 0.5149 mL 2.5747 mL 5.1493 mL 10.2987 mL 12.8733 mL
    50 mM 0.103 mL 0.5149 mL 1.0299 mL 2.0597 mL 2.5747 mL
    100 mM 0.0515 mL 0.2575 mL 0.5149 mL 1.0299 mL 1.2873 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Caffeine References Information
    Citation [1]

    Reprod Biol. 2015 Mar;15(1):20-6.

    Caffeine stimulates in vitro pituitary LH secretion in lipopolysaccharide-treated ewes.[Pubmed: 25726373]
    The effect of Caffeine on LH secretion was stronger in the LPS-treated group than in saline-treated group, and the observed LH release was similar to that induced by GnRH alone (27.2ng/mg). Caffeine increased (p<0.05) LHβ gene expression only in explants from LPS-treated animals. In conclusion, the results of the present study demonstrated a stimulatory in vitro effect of Caffeine on LH secretion by ovine pituitary explants. The potency of the Caffeine-induced LH secretion was affected by in vivo treatment of the animals with endotoxin.
    Citation [2]

    Am J Physiol Cell Physiol. 2015 Feb 25

    Caffeine inhibits glucose transport by binding at the GLUT1 nucleotide-binding site.[Pubmed: 25715702]
    GLUT1 is the primary glucose transport protein of the cardiovascular system and astroglia. A recent study proposes that Caffeine uncompetitive inhibition of GLUT1 results from interactions at an exofacial GLUT1 site. Intracellular ATP is also an uncompetitive GLUT1 inhibitor and shares structural similarities with Caffeine suggesting that Caffeine acts at the previously characterized endofacial GLUT1 nucleotide-binding site.
    Citation [3]

    Neuroscience. 2015 Feb 11. pii: S0306-4522(15)00146-3.

    Anxiolytic-like, stimulant and neuroprotective effects of Ilex paraguariensis extracts in mice.[Pubmed: 25681522]
    Overall, our results indicate the importance of the I. paraguariensis-induced CNS effects, since it is a widely used nutraceutical. We have reported anxiolytic, stimulant and neuroprotective effects for this plant species. These effects are potentially modulated by the cholinergic system as well as by Caffeine.