Cedrin | CAS:75513-81-4 | Manufacturer ChemFaces

Cedrin

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Description:

Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative stress, improvement of mitochondrial dysfunction and suppression of apoptosis.

Targets:

Bcl-2/Bax | Caspase | Beta Amyloid

In vivo:

Nat Prod Res. 2017 Jun 29:1-4.

Cedrin identified from Cedrus deodara (Roxb.) G. Don protects PC12 cells against neurotoxicity induced by Aβ1-42.[Pubmed: 28658984 ]

Alzheimer's disease is a severe neurodegenerative disease affecting elder worldwide and closely related to the neurotoxicity induced by amyloid β.
METHODS AND RESULTS:
To find efficient therapeutics, we have investigated the protective effects of Cedrin from Cedrus deodara (Roxb.) G. Don on PC12 cells against the neurotoxicity induced by amyloid β1-42. The results have shown the viability of PC12 cells injured by amyloid β1-42 can be improved by Cedrin. Cedrin can reduce reacrive oxygen species overproduction, increase the activity of superoxide dismutase and decrease malondialdehyde content. Meanwhile, the loss of mitochondrial membrane potential and mitochondrial permeability transition pore opening in PC12 cells, and elevated Caspase-3 activity, downregulated Bcl-2 and upregulated Bax are meliorated.
CONCLUSIONS:
These results demonstrate the protective effect of Cedrin is related to the inhibition of oxidative stress, improvement of mitochondrial dysfunction and suppression of apoptosis. This investigation gives evidences for the application of Cedrin in practice and further investigation in vivo.

Cedrin Description

Source:	The herbs of Cedrus deodara
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Cedrin
Price:
CAS No.:	75513-81-4
Catalog No.:	CFN97872
Molecular Formula:	C₁₆H₁₄O₈
Molecular Weight:	334.3 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The herbs of Cedrus deodara
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Neuroprotection Compound Library Flavonoids Compound Library Caspase Inhibitor Library Beta Amyloid Inhibitor Library Bcl-2/Bax Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9913 mL	14.9566 mL	29.9133 mL	59.8265 mL	74.7831 mL
5 mM	0.5983 mL	2.9913 mL	5.9827 mL	11.9653 mL	14.9566 mL
10 mM	0.2991 mL	1.4957 mL	2.9913 mL	5.9827 mL	7.4783 mL
50 mM	0.0598 mL	0.2991 mL	0.5983 mL	1.1965 mL	1.4957 mL
100 mM	0.0299 mL	0.1496 mL	0.2991 mL	0.5983 mL	0.7478 mL

CFN97274	Blumeatin B	79995-67-8	332.3	C₁₇H₁₆O₇
CFN98671	Dihydrorobinetin	4382-33-6	304.3	C₁₅H₁₂O₇
CFN98326	Ampelopsin	27200-12-0	320.3	C₁₅H₁₂O₈
CFN97204	Sepinol	72061-63-3	318.3	C₁₆H₁₄O₇
CFN97912	Cedeodarin	31076-39-8	318.3	C₁₆H₁₄O₇
CFN97872	Cedrin	75513-81-4	334.3	C₁₆H₁₄O₈
CFN92413	(-)-Dihydroquercetin	111003-33-9	304.3	C₁₅H₁₂O₇
CFN98734	Taxifolin	480-18-2	304.3	C₁₅H₁₂O₇
CFN97280	Padmatin	80453-44-7	318.3	C₁₆H₁₄O₇
CFN96563	Deodarin	33788-39-5	318.29	C₁₆H₁₄O₇