Science | Nature | Cell | View More
Natural Products
Cedrusin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Cedrusin
Price: $318 / 5mg
CAS No.: 75775-36-9
Catalog No.: CFN97237
Molecular Formula: C19H22O6
Molecular Weight: 346.4 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The herbs of Forsythia suspensa
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $270.3 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Semmelweis Unicersity (Hungary)
  • University Medical Center Mainz (Germany)
  • Universite de Lille1 (France)
  • Kamphaengphet Rajabhat University (Thailand)
  • Complutense University of Madrid (Spain)
  • Centralised Purchases Unit (CPU... (India)
  • Chulalongkorn University (Thailand)
  • Universite Libre de Bruxelles (Belgium)
  • Biotech R&D Institute (USA)
  • University of Helsinki (Finland)
  • Sapienza University of Rome (Italy)
  • More...
Package
Featured Products
Vanillic acid

Catalog No: CFN99331
CAS No: 121-34-6
Price: $30/20mg
Notoginsenoside Fe

Catalog No: CFN93282
CAS No: 88105-29-7
Price: $100/20mg
L-Menthol

Catalog No: CFN98123
CAS No: 2216-51-5
Price: $30/20mg
Pinostrobin

Catalog No: CFN98739
CAS No: 480-37-5
Price: $218/20mg
Strychnine

Catalog No: CFN98130
CAS No: 57-24-9
Price: $60/20mg
Dihydrocapsaicin

Catalog No: CFN99918
CAS No: 19408-84-5
Price: $50/20mg
Ajugol

Catalog No: CFN90759
CAS No: 52949-83-4
Price: $80/20mg
Lupeol

Catalog No: CFN98913
CAS No: 545-47-1
Price: $40/20mg
Ardisiacrispin A

Catalog No: CFN90177
CAS No: 23643-61-0
Price: $268/5mg
Quercitrin

Catalog No: CFN98850
CAS No: 522-12-3
Price: $40/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Cedrusin shows a cytotoxic effect on A375 and HeLa cells.
Targets: Caspase | PARP
In vitro:
Int J Mol Sci. 2017 Feb 13;18(2). pii: E392.
Hazelnut (Corylus avellana L.) Shells Extract: Phenolic Composition, Antioxidant Effect and Cytotoxic Activity on Human Cancer Cell Lines.[Pubmed: 28208804]
Hazelnut shells, a by-product of the kernel industry processing, are reported to contain high amount of polyphenols. However, studies on the chemical composition and potential effects on human health are lacking.
METHODS AND RESULTS:
A methanol hazelnut shells extract was prepared and dried. Our investigation allowed the isolation and characterization of different classes of phenolic compounds, including neolignans, and a diarylheptanoid, which contribute to a high total polyphenol content (193.8 ± 3.6 mg of gallic acid equivalents (GAE)/g of extract). Neolignans, lawsonicin and Cedrusin, a cyclic diarylheptanoid, carpinontriol B, and two phenol derivatives, C-veratroylglycol, and β-hydroxypropiovanillone, were the main components of the extract (0.71%-2.93%, w/w). The biological assays suggested that the extract could be useful as a functional ingredient in food technology and pharmaceutical industry showing an in vitro scavenging activity against the radical 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) (EC50 = 31.7 μg/mL with respect to α-tocopherol EC50 = 10.1 μg/mL), and an inhibitory effect on the growth of human cancer cell lines A375, SK-Mel-28 and HeLa (IC50 = 584, 459, and 526 μg/mL, respectively).
CONCLUSIONS:
The expression of cleaved forms of caspase-3 and poly(ADP-ribose) polymerase-1 (PARP-1) suggested that the extract induced apoptosis through caspase-3 activation in both human malignant melanoma (SK-Mel-28) and human cervical cancer (HeLa) cell lines. The cytotoxic activity relies on the presence of the neolignans (balanophonin), and phenol derivatives (gallic acid), showing a pro-apoptotic effect on the tested cell lines, and the neolignan, Cedrusin, with a cytotoxic effect on A375 and HeLa cells.
Cedrusin Description
Source: The herbs of Forsythia suspensa
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
2-Phenylethyl-beta-glucopyranoside

Catalog No: CFN95429
CAS No: 18997-54-1
Price: $318/10mg
erythro-Austrobailignan-6

Catalog No: CFN95501
CAS No: 114127-24-1
Price: $318/10mg
8,8''-Bibaicalein

Catalog No: CFN95007
CAS No: 135309-02-3
Price: $318/5mg
Lappaol A

Catalog No: CFN95067
CAS No: 62333-08-8
Price: $333/10mg
Tortoside B (Manglieside E)

Catalog No: CFN95390
CAS No: 190655-17-5
Price: $413/5mg
Margaritene

Catalog No: CFN95303
CAS No: 64271-10-9
Price: $318/10mg
Resinacein D

Catalog No: CFN95591
CAS No: 2231061-47-3
Price: $413/5mg
Ganoderic acid GS-2

Catalog No: CFN95549
CAS No: 1206781-65-8
Price: $413/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8868 mL 14.4342 mL 28.8684 mL 57.7367 mL 72.1709 mL
5 mM 0.5774 mL 2.8868 mL 5.7737 mL 11.5473 mL 14.4342 mL
10 mM 0.2887 mL 1.4434 mL 2.8868 mL 5.7737 mL 7.2171 mL
50 mM 0.0577 mL 0.2887 mL 0.5774 mL 1.1547 mL 1.4434 mL
100 mM 0.0289 mL 0.1443 mL 0.2887 mL 0.5774 mL 0.7217 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Vanillic acid

Catalog No: CFN99331
CAS No: 121-34-6
Price: $30/20mg
Notoginsenoside Fe

Catalog No: CFN93282
CAS No: 88105-29-7
Price: $100/20mg
L-Menthol

Catalog No: CFN98123
CAS No: 2216-51-5
Price: $30/20mg
Pinostrobin

Catalog No: CFN98739
CAS No: 480-37-5
Price: $218/20mg
Strychnine

Catalog No: CFN98130
CAS No: 57-24-9
Price: $60/20mg
Dihydrocapsaicin

Catalog No: CFN99918
CAS No: 19408-84-5
Price: $50/20mg
Ajugol

Catalog No: CFN90759
CAS No: 52949-83-4
Price: $80/20mg
Lupeol

Catalog No: CFN98913
CAS No: 545-47-1
Price: $40/20mg
Ardisiacrispin A

Catalog No: CFN90177
CAS No: 23643-61-0
Price: $268/5mg
Quercitrin

Catalog No: CFN98850
CAS No: 522-12-3
Price: $40/20mg
Tags: buy Cedrusin | Cedrusin supplier | purchase Cedrusin | Cedrusin cost | Cedrusin manufacturer | order Cedrusin | Cedrusin distributor