ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
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More articles cited ChemFaces products.
Molecules.2013 Jun 24;18(7):7376-88.SBRAS2016(12)Sci Rep. 2017 Jun 12;Acta Agriculturae ScandinavicaJan. 18, 2016Experimental Parasitology2015 March 24.
Plant J. 2017 May;J Ethnopharmacol.2018 Jan 10;Molecules.2017 Oct 27;J. Int. J. of Food Properties 13 Feb 2017Phytomedicine.2018 Jan 1;
Molecules.2013 Nov 14;18(11):14105-21. J Ethnopharmacol. 2016 Jul 12.Evid Based Complement Alternat Med. 2017:1583185Jour. of Stored Pro & Postharvest Res.March 2016
Our products had been exported to the following research institutions and universities, And still growing.
Universidade da Beira Interior (Germany)National Chung Hsing University (Taiwan)Seoul National University (Korea)Molecular Biology Institute of B... (Spain)
Universidade Federal de Goias (U... (Brazil)Uniwersytet Gdański (Poland)Monash University Sunway Campus (Malaysia)Universidad de Buenos Aires (Argentina)
John Innes Centre (United Kingdom)University of Beira Interior (Portugal)Pennsylvania State University (USA)
||The flower buds of Chimonanthus praecox
|Biological Activity or Inhibitors:
||1. (-)-Chimonanthine (IC50 = 0.93 uM) shows potent inhibitory effects on melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Chimonanthine References Information
J Nat Med. 2014 Jul;68(3):539-49.
|Dimeric pyrrolidinoindoline-type alkaloids with melanogenesis inhibitory activity in flower buds of Chimonanthus praecox.[Pubmed: 24668298]|
|A methanol extract of the flower buds of Chimonanthus praecox (L.) Link (Calycanthaceae) demonstrated inhibitory effects on melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. From the extract, five dimeric pyrrolidinoindoline alkaloids and four sesquiterpenes were isolated, together with 16 known compounds. Among them, (-)-Chimonanthine (1, IC50 = 0.93 μM), (-)-folicanthine (2, 1.4 μM), and (-)-calycanthidine (3, 1.8 μM) showed potent inhibitory effects without notable cytotoxicity at the effective concentrations. The most potent alkaloid (1) inhibited both tyrosinase and tyrosine-related protein-1 mRNA expressions, to which the melanogenesis inhibitory activity would be ascribable.