Chlorahololide C | CAS:1007859-25-7 | Manufacturer ChemFaces

Chlorahololide C

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Description:

Chlorahololide C is a potent and selective potassium channel blocker, it exerts potent and selective inhibition on the delayed rectifier (I(K)) K(+) current with the IC(50) value of 3.6 +/- 10.1 mu M.

Targets:

Potassium Channel

In vitro:

Tetrahedron, 2008, 64(9):2027-2034.

Chlorahololides C–F: a new class of potent and selective potassium channel blockers from Chloranthus holostegius[Reference: WebLink]

METHODS AND RESULTS:
Four unusually fused polycyclic sesquiterpenoid dimers, Chlorahololide C,chlorahololide D, chlorahololide E, chlorahololide F (1 - 4), were isolated from the whole plant of Chloranthus holostegius. Their structures and absolute configurations were established by spectroscopic methods, including 2D NMR and CD spectra.
CONCLUSIONS:
Chlorahololides C - F (1 - 4) exerted potent and selective inhibition on the delayed rectifier (I(K)) K(+) current with the IC(50) values of 3.6 +/- 10.1, 2.7 +/- 0.3, 27.5 +/- 5.1. and 57.5 +/- 6.1 mu M, respectively.

Chlorahololide C Description

Source:	The whole plants of Chloranthus holostegius.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Chlorahololide C
Price:
CAS No.:	1007859-25-7
Catalog No.:	CFN96953
Molecular Formula:	C₃₃H₃₆O₉
Molecular Weight:	576.64 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	The whole plants of Chloranthus holostegius.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Sesquiterpenoids Compound Library Potassium Channel Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.7342 mL	8.6709 mL	17.3418 mL	34.6837 mL	43.3546 mL
5 mM	0.3468 mL	1.7342 mL	3.4684 mL	6.9367 mL	8.6709 mL
10 mM	0.1734 mL	0.8671 mL	1.7342 mL	3.4684 mL	4.3355 mL
50 mM	0.0347 mL	0.1734 mL	0.3468 mL	0.6937 mL	0.8671 mL
100 mM	0.0173 mL	0.0867 mL	0.1734 mL	0.3468 mL	0.4335 mL

CFN99462	Shizukaol D	142279-42-3	578.7	C₃₃H₃₈O₉
CFN99461	Shizukaol C	142279-41-2	634.7	C₃₆H₄₂O₁₀
CFN96800	Chloramultilide D	1000995-49-2	636.69	C₃₅H₄₀O₁₁
CFN97521	Chlorahololide D	943136-39-8	676.8	C₃₈H₄₄O₁₁
CFN96328	Sarcandrolide D	1207185-03-2	678.7	C₃₇H₄₂O₁₂
CFN96325	Chloramultilide C	1000995-48-1	734.8	C₃₉H₄₂O₁₄
CFN96320	Chloramultilide B	1000995-47-0	734.8	C₃₉H₄₂O₁₄
CFN96675	Shizukaol B	142279-40-1	732.77	C₄₀H₄₄O₁₃
CFN92897	Shizukaol G	165171-11-9	748.77	C₄₀H₄₄O₁₄
CFN96270	Cycloshizukaol A	150033-85-5	548.6	C₃₂H₃₆O₈