Chonglou Saponin VII | CAS:68124-04-9 | Manufacturer ChemFaces

Chonglou Saponin VII

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Size /Price /Stock	10 mM * 1 mL in DMSO / $54.8 / In-stock
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Description:

Chonglou saponin VII shows inhibitory effects on cell proliferation.

In vitro:

Zhonghua yi xue za zhi, 01 Jun 2015,95(23):1859-1861.

Effects of Paris polyphylla saponin VII plus silica nano composite on ovarian cancer drug resistance in vitro.[Pubmed: 26712407]

To explore the drug resistance of Chonglou Saponin VII plus silica nano complex for ovarian cancer.
METHODS AND RESULTS:
The method of thiazolyl blue tetrazolium blue (MTT) was employed for determining the proliferation inhibition rate of Chonglou Saponin VII plus silica nano composite for SKOV3/DDP drug-resistant human ovarian cancer cell. Flow cytometry and Hoechst 33342 staining were used for detecting apoptosis rate and cell cycle phase distribution. And the changes of apoptosis-related protein were examined by immunoblot assay.There were obvious inhibitory effects of Chonglou Saponin VII on cell proliferation. The inhibition rate increased with rising drug concentration with an obvious dose-effect relationship (P < 0.05). At the same time, the cell proliferation inhibition rate significantly improved at 48 h versus 24 h (P < 0.05). Flow cytometry and Hoechst 33342 staining showed that, after a 24 h treatment of SKOV3/DDP cells with 50 and 100 μmol/L Chonglou Saponin VII, early apoptotic cell ratio significantly increased compared with control group.
CONCLUSIONS:
The composite of Paris polyphylla saponin VII and silica nano has obvious proliferation inhibitory effects on SKOV3/DDP cells. And there is a significant concentration dependence and it also has some correlation with time. The above composite can increased the proportion of early apoptotic cell ratio.

Chonglou Saponin VII Description

Source:	The roots of Paris polyphylla
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Chinese Journal of Pharmaceutical Analysis,2011,31(9):1641-5.

Analysis of four saponins in Rhizoma Paridis with substitution method of reference substance[Reference: WebLink]

To establish a quantitative analysis method of four saponins(Chonglou saponin Ⅰ,Chonglou saponin Ⅱ,Chonglou saponin Ⅵ, Chonglou Saponin VII)in Rhizoma Paridis with a substitute standard.
METHODS AND RESULTS:
An HPLC method was builded to determine the four saponins while saikosaponin d was used as substitute standard.The method was established by an Waters SymmetryShield RP18(4.6 mm×250 mm,5 μm)column with 27 ℃ column temperature,the mobile phase of acetonitrile-water with the gradient elution at a flow rate of 1.0 mL·min-1,and the detection wavelength of 203 nm.The four calibration curves which were made by the ratio of peak areas and concentrations were in good linearities,and the recovery was between 101.6% and 104.2%.
CONCLUSIONS:
Saikosaponin d can be used as the substitute standard to determinate the four saponins in Rhizoma Paridis simultaneously.

Product Name	Chonglou Saponin VII
Price:	$100 / 20mg
CAS No.:	68124-04-9
Catalog No.:	CFN97162
Molecular Formula:	C₅₁H₈₂O₂₁
Molecular Weight:	1031.2 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The roots of Paris polyphylla
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-proliferation Compound Library Steroids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	0.9697 mL	4.8487 mL	9.6974 mL	19.3949 mL	24.2436 mL
5 mM	0.1939 mL	0.9697 mL	1.9395 mL	3.879 mL	4.8487 mL
10 mM	0.097 mL	0.4849 mL	0.9697 mL	1.9395 mL	2.4244 mL
50 mM	0.0194 mL	0.097 mL	0.1939 mL	0.3879 mL	0.4849 mL
100 mM	0.0097 mL	0.0485 mL	0.097 mL	0.1939 mL	0.2424 mL

CFN99954	Polyphyllin VI	55916-51-3	738.91	C₃₉H₆₂O₁₃
CFN99055	Mannioside A	1038922-95-0	738.9	C₃₉H₆₂O₁₃
CFN90638	Ophiogenin-3-O-alpha-L-rhaMnopyranosyl-(1->2)-beta-D-glucopyranoside	128502-94-3	754.9	C₃₉H₆₂O₁₄
CFN70458	Shatavarin IV	84633-34-1	887.1	C₄₅H₇₄O₁₇
CFN90636	14-Hydroxy sprengerinin C	1111088-89-1	871.02	C₄₄H₇₀O₁₇
CFN90614	17-Hydroxy sprengerinin C	1029017-75-1	871.02	C₄₄H₇₀O₁₇
CFN96366	Sprengerinin C	88861-91-0	855.0	C₄₄H₇₀O₁₆
CFN96364	2''-O-Acetylsprengerinin C	1220707-33-4	897.1	C₄₆H₇₂O₁₇
CFN92807	Glucopyranoside,(3beta,25R)-17-hydroxyspirost-5-en-3-yl	84914-58-9	870.5	C₄₄H₇₀O₁₇
CFN90701	Polyphyllin H	81917-50-2	871.0	C₄₄H₇₀O₁₇