Science | Nature | Cell | View More
Natural Products
Clemastanin B
Clemastanin B
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Clemastanin B
Price: $368 / 20mg
CAS No.: 112747-98-5
Catalog No.: CFN95064
Molecular Formula: C32H44O16
Molecular Weight: 684.7 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The roots of Stellera chamaejasme L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $163.3 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Uniwersytet Gdański (Poland)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Sanford Burnham Medical Researc... (USA)
  • University of Madras (India)
  • National Chung Hsing University (Taiwan)
  • University of East Anglia (United Kingdom)
  • University of Parma (Italy)
  • Universiti Malaysia Pahang (Malaysia)
  • Sri Sai Aditya Institute of Pha... (India)
  • Seoul National University (Korea)
  • Anna University (India)
  • More...
Package
Featured Products
Kuwanon G

Catalog No: CFN93278
CAS No: 75629-19-5
Price: $218/20mg
Corynantheine

Catalog No: CFN92843
CAS No: 18904-54-6
Price: $ / mg
L-Valine

Catalog No: CFN94831
CAS No: 72-18-4
Price: $30/20mg
Ganoderenic acid D

Catalog No: CFN90300
CAS No: 100665-43-8
Price: $368/20mg
Diallyl disulfide

Catalog No: CFN93237
CAS No: 2179-57-9
Price: $50/20mg
Benzoylpaeoniflorin

Catalog No: CFN99536
CAS No: 38642-49-8
Price: $80/20mg
Punicalagin

Catalog No: CFN99938
CAS No: 65995-63-3
Price: $108/20mg
Fangchinoline

Catalog No: CFN99167
CAS No: 436-77-1
Price: $40/20mg
Complanatoside B

Catalog No: CFN80156
CAS No: 142473-99-2
Price: $218/10mg
N1,N10-Bis(p-coumaroyl)spermidine

Catalog No: CFN99248
CAS No: 114916-05-1
Price: $ /
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Clemastanin B has antioxidant and anti-inflammatory activities, it exerts its anti-influenza activity by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment.
Targets: Influenza virus | Immunology & Inflammation related
In vitro:
J Tradit Chin Med. 2016 Jun;36(3):369-76.
Antiviral activities against influenza virus (FM1) of bioactive fractions and representative compounds extracted from Banlangen (Radix Isatidis).[Pubmed: 27468553]
To study the antiviral activities of Clemastanin B (CB), epigoitrin, phenylpropanoids portion (PEP) and the mixture of phenylpropanoids, alkaloids and organic acid fractions (PEP ALK OA) from Banlangen (Radix Isatidis).
METHODS AND RESULTS:
The experiment consisted of four parts: therapeutic action, prophylaxsis action, inhibition of virus attachment, and direct virucidal action. Cytopathic effect (CPE) and 3-(4,5-Dimethylthiazol-2-yI)-2,5-diphenyltetrazolium (MTT) were used to assess antiviral activity. CB, epigoitrin, PEP and PEP ALK OA fractions from Banlangen (Radix Isatidis) extract significantly increased the viability of MDCK cells pre-infected with the virus compared with the virus control group in all the dilutions (P < 0.01). Pretreated with either pure compounds or chemical fractions of Banlangen (Radix Isatidis) extract in all the dilutions significantly improved the viability of MDCK cells (P < 0.01). The inhibition of virus absorption to the host cells by CB, epigoitrin and PEP was in a dose dependent manner.
CONCLUSIONS:
CB, epigoitrin, PEP and PEP ALK OA exert their anti-influenza activity by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment. The primary mode of action of PEP and PEP ALK OA is the inhibition of virus replication. The inhibitory effects on virus attachment and multiplication are the main modes for epigoitrin.
In vivo:
J Ethnopharmacol. 2014 Nov 18;157:55-61.
In vitro antioxidant and anti-inflammatory activities of Radix Isatidis extract and bioaccessibility of six bioactive compounds after simulated gastro-intestinal digestion.[Pubmed: 25256688]
Radix Isatidis called "Ban-Lan-Gen" is one of the most commonly-used traditional Chinese medicines for antiviral, anti-inflammatory, antioxidant and antipyretic purposes. Investigate the bioaccessibility of uridine, epigoitrin, adenosine, Clemastanin B, indigoticoside A and isolariciresinol as well as the antioxidant and anti-inflammatory activities during an in vitro gastro-intestinal digestion of the Radix Isatidis extract (RIE).
METHODS AND RESULTS:
High performance liquid chromatography (HPLC) technique was adopted to determine the bioaccessibility of six bioactive compounds in RIE. Antioxidant activities of RIE in different digestive stages were determined by 1,1-Diphenyl-2-picrylhydrazyl (DPPH), superoxide anion and hydroxyl radical scavenging abilities. Anti-inflammatory activity was assayed by the inhibitions of inflammatory cytokines such as nitrous oxide (NO), prostaglandin E2 (PGE2) and tumor necrosis factor α(TNF-α) producted by lipopolysaccharide (LPS) stimulated RAW264.7 cells. The bioaccessibility of uridine, epigoitrin, adenosine, Clemastanin B, indigoticoside A and isolariciresinol were 15.38%, 18.28%, 24.01%, 6.50%, 8.65% and 17.78%, respectively. Also, the digestion products still possessed certain antioxidant activities. The antioxidant activity was highly correlated with lignans (Clemastanin B, indigoticoside A and isolariciresino). The anti-inflammation activity of the three samples decreased in the order: IN sample (the solution that had diffused into the dialysis tubing)>Nondigested sample (RIE solution)>Gastric sample (post-gastric digestion)>OUT sample (material that remained in the gastro-intestinal tract).
CONCLUSIONS:
Results obtained in this research reveal the amount of bioactive compounds from RIE that could be available for absorption in vivo. The antioxidant activity decreased significantly but the anti-inflammatory activity was enhanced in serum-available fraction after gastro-intestinal digestion in vitro. This study could provide a scientific basis for a deeper pharmacological activity study of Radix Isatidis and a simple method for pharmacodynamic material basis research.
Clemastanin B Description
Source: The roots of Stellera chamaejasme L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Arvenin III

Catalog No: CFN95327
CAS No: 65597-45-7
Price: $318/5mg
Kidjolanin

Catalog No: CFN95503
CAS No: 38395-01-6
Price: $318/5mg
3-O-Methylellagic acid 3'-O-alpha-...

Catalog No: CFN95375
CAS No: 352280-34-3
Price: $413/5mg
Batatasin IV

Catalog No: CFN95319
CAS No: 60347-67-3
Price: $318/5mg
1-Methyl-2,8-dihydroxy-3-carboxy-9...

Catalog No: CFN95101
CAS No: 1401414-53-6
Price: $338/5mg
Peiioside B

Catalog No: CFN95336
CAS No: 1610618-91-1
Price: $318/5mg
Lathyranoic acid A

Catalog No: CFN95325
CAS No: 850560-44-0
Price: $318/5mg
Naringenin 7-O-gentiobioside

Catalog No: CFN95435
CAS No: 104154-33-8
Price: $368/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.4605 mL 7.3025 mL 14.6049 mL 29.2099 mL 36.5123 mL
5 mM 0.2921 mL 1.4605 mL 2.921 mL 5.842 mL 7.3025 mL
10 mM 0.146 mL 0.7302 mL 1.4605 mL 2.921 mL 3.6512 mL
50 mM 0.0292 mL 0.146 mL 0.2921 mL 0.5842 mL 0.7302 mL
100 mM 0.0146 mL 0.073 mL 0.146 mL 0.2921 mL 0.3651 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Kuwanon G

Catalog No: CFN93278
CAS No: 75629-19-5
Price: $218/20mg
Corynantheine

Catalog No: CFN92843
CAS No: 18904-54-6
Price: $ / mg
L-Valine

Catalog No: CFN94831
CAS No: 72-18-4
Price: $30/20mg
Ganoderenic acid D

Catalog No: CFN90300
CAS No: 100665-43-8
Price: $368/20mg
Diallyl disulfide

Catalog No: CFN93237
CAS No: 2179-57-9
Price: $50/20mg
Benzoylpaeoniflorin

Catalog No: CFN99536
CAS No: 38642-49-8
Price: $80/20mg
Punicalagin

Catalog No: CFN99938
CAS No: 65995-63-3
Price: $108/20mg
Fangchinoline

Catalog No: CFN99167
CAS No: 436-77-1
Price: $40/20mg
Complanatoside B

Catalog No: CFN80156
CAS No: 142473-99-2
Price: $218/10mg
N1,N10-Bis(p-coumaroyl)spermidine

Catalog No: CFN99248
CAS No: 114916-05-1
Price: $ /
Tags: buy Clemastanin B | Clemastanin B supplier | purchase Clemastanin B | Clemastanin B cost | Clemastanin B manufacturer | order Clemastanin B | Clemastanin B distributor