Clopidogrel Related Compound A | CAS:144457-28-3

Clopidogrel Related Compound A

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Clopidogrel Related Compound A Description

Source:	From Clopidogrel
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Der Pharma Chemica;2010,2(4):244.

Non chiral High Performance Liquid Chromatography method for monitoring unknown impurities generated during stability of Clopidogrel tablets[Reference: WebLink]

The purpose of this study was to develop a High performance liquid chromatography (HPLC) method for separating the unknown impurities generated during the accelerated stability storage of Clopidogrel Bisulphate Tablets. Also, we used the newly developed method to identify the factors that contribute to the formation of these unknown impurities in the tablet formulation.
METHODS AND RESULTS:
Study was carried out by incubation of mixture of excipients and Clopidogrel API in 5:1 ratio at 80Â°C for 3days. The new HPLC method was developed by using Kromasil 100 C18 column and using gradient method with mobile phase of 0.1% Triflouroacetic acid in water in pump A and 0.1% Trifluoroacetic acid in Acetonitrile in pump B was suitable for separating the unknown impurities from the Clopidogrel Related Compound A.The method discussed in United States Pharmacopoeia (USP) is not suitable to separate these impurities. From the excipients compatibility data we hypothesized that these unknown impurities were generated due to the excipient Polyethylene Glycol that is present in the tablet both as a tablet lubricant as well as a part of the film coating system. Further these unknown impurities were characterized as Dihydro pyridinone Derivative, Decarbmethoxylated Clopidogrel.

Product Name	Clopidogrel Related Compound A
Price:
CAS No.:	144457-28-3
Catalog No.:	CFN90546
Molecular Formula:	C₁₅H₁₄ClNO₂S
Molecular Weight:	307.8 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	From Clopidogrel
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.2489 mL	16.2443 mL	32.4886 mL	64.9773 mL	81.2216 mL
5 mM	0.6498 mL	3.2489 mL	6.4977 mL	12.9955 mL	16.2443 mL
10 mM	0.3249 mL	1.6244 mL	3.2489 mL	6.4977 mL	8.1222 mL
50 mM	0.065 mL	0.3249 mL	0.6498 mL	1.2995 mL	1.6244 mL
100 mM	0.0325 mL	0.1624 mL	0.3249 mL	0.6498 mL	0.8122 mL

CFN92921	Dauriporphine	88142-60-3	351.35	C₂₀H₁₇NO₅
CFN92919	Dauriporphinoline	100009-82-3	337.33	C₁₉H₁₅NO₅
CFN92920	Menisporphine	83287-02-9	321.33	C₁₉H₁₅NO₄
CFN90546	Clopidogrel Related Compound A	144457-28-3	307.8	C₁₅H₁₄ClNO₂S
CFN90547	Clopidogrel Related Compound B	144750-52-7	358.3	C₁₆H₁₇ClNO₂SCl
CFN90548	Clopidogrel Related Compound C	120202-71-3	419.9	C₁₆H₁₈ClNO₆S₂