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Crenatine
Crenatine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Crenatine
Price:
CAS No.: 26585-14-8
Catalog No.: CFN98313
Molecular Formula: C14H14N2O
Molecular Weight: 226.3 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The barks of Quassia undulata
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Crenatine possesses antibacterial activity, it is more effective against Gram-positive than Gram-negative bacteria.
Targets: Antifection
In vitro:
Phytotherapy Research. 1995 February; 9(1):69–71.
Antimicrobial activity of crenatine, an alkaloid synthesized from indole.[Reference: WebLink]

METHODS AND RESULTS:
Synthesized Crenatine, a B-carboline alkaloid previously isolated from Quassia undulata (Guill & Perr) D. Dietr (Simaroubaceae) is shown to possess antibacterial but no antifungal activity. The activity was tested in vitro against seven Gram-positive, ten Gram-negative bacteria and a yeast at a concentration of 1 mg/mL.
CONCLUSIONS:
The compound was found to be more effective against Gram-positive than Gram-negative bacteria.
Crenatine Description
Source: The barks of Quassia undulata
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.4189 mL 22.0946 mL 44.1891 mL 88.3783 mL 110.4728 mL
5 mM 0.8838 mL 4.4189 mL 8.8378 mL 17.6757 mL 22.0946 mL
10 mM 0.4419 mL 2.2095 mL 4.4189 mL 8.8378 mL 11.0473 mL
50 mM 0.0884 mL 0.4419 mL 0.8838 mL 1.7676 mL 2.2095 mL
100 mM 0.0442 mL 0.2209 mL 0.4419 mL 0.8838 mL 1.1047 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Chemical & pharmaceutical bulletin.1991 Aug 25;39(9):2189-2195.
Synthetic Studies of Indoles and Related Compounds. XXVII. A New Synthesis of Crenatine from Ethyl Indole-2-carboxylate[Reference: WebLink]

METHODS AND RESULTS:
Crenatine (1a), which is a member of a new class of β-carboline alkaloids having an oxygen functionality at the 4-position, was synthesized starting from ethyl 1-benzylindole-2-carboxylate (12a) via cyclization of an elaborated C_2-subsitituent to the 3-position of the indole nucleus and aluminum chloride-catalyzed debenzylation of the protected indolic nitrogen.
CONCLUSIONS:
1-Ethyl-4-hydroxy-9-methyl-β-carboline (26b), a positional isomer of Crenatine with regard to the methyl group, was also synthesized through the same methodology.
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Price: $40/20mg
Andrographolide

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CAS No: 5508-58-7
Price: $30/20mg
DL-alpha-Tocopherol

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Capsanthin

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