Science | Nature | Cell | View More
Natural Products
Cristacarpin
Cristacarpin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Cristacarpin
Price:
CAS No.: 74515-47-2
Catalog No.: CFN96024
Molecular Formula: C21H22O5
Molecular Weight: 354.4 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The herbs of Erythrina burana
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Lund University (Sweden)
  • University of Vienna (Austria)
  • Kyushu University (Japan)
  • University of Leipzig (Germany)
  • University of Vigo (Spain)
  • Charles University in Prague (Czech Republic)
  • University of Maryland (USA)
  • Sapienza University of Rome (Italy)
  • Fraunhofer-Institut für Moleku... (Germany)
  • Uniwersytet Jagielloński w Kra... (Poland)
  • Universidad de Antioquia (Colombia)
  • More...
Package
Featured Products
Quercetin-3-O-glucuronide

Catalog No: CFN92172
CAS No: 22688-79-5
Price: $238/20mg
(+)-Longifolene

Catalog No: CFN70117
CAS No: 475-20-7
Price: $30/20mg
Soyasaponin Ac

Catalog No: CFN90774
CAS No: 133882-74-3
Price: $ / mg
Procyanidin B3

Catalog No: CFN99559
CAS No: 23567-23-9
Price: $238/10mg
Rubiadin 1-methyl ether

Catalog No: CFN97227
CAS No: 7460-43-7
Price: $268/10mg
(-)-Gallocatechin gallate

Catalog No: CFN99571
CAS No: 4233-96-9
Price: $60/20mg
Genistin

Catalog No: CFN90250
CAS No: 529-59-9
Price: $40/20mg
Caffeine

Catalog No: CFN99004
CAS No: 58-08-2
Price: $30/20mg
Coelonin

Catalog No: CFN92693
CAS No: 82344-82-9
Price: $388/5mg
Asperosaponin VI

Catalog No: CFN99766
CAS No: 39524-08-8
Price: $30/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-lethal reactive oxygen species (ROS) generation and which eventually terminates by triggering senescence in pancreatic and breast cancer cells through blocking the cell cycle in the G1 phase.
Targets: ROS | p21 | Cdk | p53 | p38MAPK | Antifection
In vitro:
J Nat Prod. 1993 Oct;56(10):1831-4.
Two bioactive pterocarpans from Erythrina burana.[Pubmed: 8277323]

METHODS AND RESULTS:
Bioactivity-directed fractionation of the CHCl3 extract of the bark of Erythrina burana afforded phaseollidin [1] and Cristacarpin [2]. Both 1 and Cristacarpin exhibited moderate but selective activity towards DNA repair-deficient yeast mutants, whereas only 1 was found to be cytotoxic. 13C-nmr spectra of both compounds were assigned.
Age (Dordr). 2016 Jun;38(3):62.
Cristacarpin promotes ER stress-mediated ROS generation leading to premature senescence by activation of p21(waf-1).[Pubmed: 27246693 ]
Stress-induced premature senescence (SIPS) is quite similar to replicative senescence that is committed by cells exposed to various stress conditions viz. ultraviolet radiation (DNA damage), hydrogen peroxide (oxidative stress), chemotherapeutic agents (cytotoxic threat), etc.
METHODS AND RESULTS:
Here, we report that Cristacarpin, a natural product obtained from the stem bark of Erythrina suberosa, promotes endoplasmic reticulum (ER) stress, leading to sub-lethal reactive oxygen species (ROS) generation and which eventually terminates by triggering senescence in pancreatic and breast cancer cells through blocking the cell cycle in the G1 phase. The majority of Cristacarpin-treated cells responded to conventional SA-β-gal stains; showed characteristic p21(waf1) upregulation along with enlarged and flattened morphology; and increased volume, granularity, and formation of heterochromatin foci-all of these features are the hallmarks of senescence. Inhibition of ROS generation by N-acetyl-L-cysteine (NAC) significantly reduced the expression of p21(waf1), confirming that the modulation in p21(waf1) by anti-proliferative Cristacarpin was ROS dependent. Further, the elevation in p21(waf1) expression in PANC-1 and MCF-7 cells was consistent with the decrease in the expression of Cdk-2 and cyclinD1.
CONCLUSIONS:
Here, we provide evidence that Cristacarpin promotes senescence in a p53-independent manner. Moreover, Cristacarpin treatment induced p38MAPK, indicating the ROS-dependent activation of the MAP kinase pathway, and thus abrogates the tumor growth in mouse allograft tumor model.
Cristacarpin Description
Source: The herbs of Erythrina burana
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Phyllanthusiin C

Catalog No: CFN95260
CAS No: 142674-52-0
Price: $318/5mg
Lyciumamide B

Catalog No: CFN95286
CAS No: 1647111-41-8
Price: $318/5mg
Rhamnocitrin 3-glucoside

Catalog No: CFN95134
CAS No: 41545-37-3
Price: $318/10mg
9-O-Acetyl-fargesol

Catalog No: CFN95031
CAS No: 449172-61-6
Price: $413/5mg
9-Octadecenedioic acid

Catalog No: CFN95301
CAS No: 4494-16-0
Price: $218/5mg
6-Methoxyfraxinellone

Catalog No: CFN95485
CAS No: N/A
Price: $318/10mg
Astin B

Catalog No: CFN95188
CAS No: 151201-76-2
Price: $318/10mg
Dehydrojuncusol

Catalog No: CFN95143
CAS No: 117824-04-1
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8217 mL 14.1084 mL 28.2167 mL 56.4334 mL 70.5418 mL
5 mM 0.5643 mL 2.8217 mL 5.6433 mL 11.2867 mL 14.1084 mL
10 mM 0.2822 mL 1.4108 mL 2.8217 mL 5.6433 mL 7.0542 mL
50 mM 0.0564 mL 0.2822 mL 0.5643 mL 1.1287 mL 1.4108 mL
100 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.5643 mL 0.7054 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Nat Prod Res. 2009;23(12):1089-94.
Three new isoflavanones from Erythrina costaricensis.[Pubmed: 19662573]

METHODS AND RESULTS:
Three new isoflavanones, 5,7,3'-trihydroxy-4'-methoxy-6,5'-di(gamma, gamma-dimethylallyl)-isoflavanone (1), 5,3'-dihydroxy-4'-methoxy-5'-gamma,gamma-dimethylallyl-2'',2''-dimethylpyrano[5,6 : 6,7]isoflavanone (2) and 5,3'-dihydroxy-2'',2''-dimethylpyrano[5,6 : 6,7]-2''',2'''-dimethylpyrano[5,6 : 5,4]isoflavanone (3), along with two known isoflavonoids, Cristacarpin and euchrenone b(10), were isolated from the stems of Erythrina costaricensis. Their structures were established on the basis of spectroscopic evidence.
CONCLUSIONS:
Compound 3 is a rare isoflavanone possessing two 2,2-dimethylpyran moieties. Among the new isoflavanones, compound 1 showed potent antibacterial activity against methicillin-resistant Staphylococcus aureus.
Quercetin-3-O-glucuronide

Catalog No: CFN92172
CAS No: 22688-79-5
Price: $238/20mg
(+)-Longifolene

Catalog No: CFN70117
CAS No: 475-20-7
Price: $30/20mg
Soyasaponin Ac

Catalog No: CFN90774
CAS No: 133882-74-3
Price: $ / mg
Procyanidin B3

Catalog No: CFN99559
CAS No: 23567-23-9
Price: $238/10mg
Rubiadin 1-methyl ether

Catalog No: CFN97227
CAS No: 7460-43-7
Price: $268/10mg
(-)-Gallocatechin gallate

Catalog No: CFN99571
CAS No: 4233-96-9
Price: $60/20mg
Genistin

Catalog No: CFN90250
CAS No: 529-59-9
Price: $40/20mg
Caffeine

Catalog No: CFN99004
CAS No: 58-08-2
Price: $30/20mg
Coelonin

Catalog No: CFN92693
CAS No: 82344-82-9
Price: $388/5mg
Asperosaponin VI

Catalog No: CFN99766
CAS No: 39524-08-8
Price: $30/20mg
Tags: buy Cristacarpin | Cristacarpin supplier | purchase Cristacarpin | Cristacarpin cost | Cristacarpin manufacturer | order Cristacarpin | Cristacarpin distributor