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Curcolone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Curcolone
Price:
CAS No.: 17015-43-9
Catalog No.: CFN92651
Molecular Formula: C15H18O3
Molecular Weight: 246.3 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Powder
Source: The rhizomes of Curcuma zedoaria
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Curcolone exhibits inhibition against collagen-induced platelet aggregation at 100 uM, it also inhibit arachidonic acid (AA)-induced platelet aggregation at 100 uM.
In vitro:
Molecules, 2016, 21(10):E1385.
New Sesquiterpenoids and Anti-Platelet Aggregation Constituents from the Rhizomes of Curcuma zedoaria.[Pubmed: 27763530 ]

METHODS AND RESULTS:
Two new sesquiterpenoids—13-hydroxycurzerenone (1) and 1-oxocurzerenone (2)—have been isolated from the rhizomes of Curcuma zedoaria, together with 13 known compounds (3–15). The structures of two new compounds were determined through spectroscopic and MS analyses. Among the isolated compounds, 13-hydroxycurzerenone (1), 1-oxocurzerenone (2), curzerenone (3), germacrone (4), Curcolone (5), procurcumenol (6), ermanin (7), curcumin (8), and a mixture of stigmast-4-en-3,6-dione (12) and stigmasta-4,22-dien-3,6-dione (13) exhibited inhibition (with inhibition % in the range of 21.28%–67.58%) against collagen-induced platelet aggregation at 100 μM.
CONCLUSIONS:
Compounds 1, 5, 7, 8, and the mixture of 12 and 13 inhibited arachidonic acid (AA)-induced platelet aggregation at 100 μM with inhibition % in the range of 23.44%–95.36%.
Curcolone Description
Source: The rhizomes of Curcuma zedoaria
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
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PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.0601 mL 20.3004 mL 40.6009 mL 81.2018 mL 101.5022 mL
5 mM 0.812 mL 4.0601 mL 8.1202 mL 16.2404 mL 20.3004 mL
10 mM 0.406 mL 2.03 mL 4.0601 mL 8.1202 mL 10.1502 mL
50 mM 0.0812 mL 0.406 mL 0.812 mL 1.624 mL 2.03 mL
100 mM 0.0406 mL 0.203 mL 0.406 mL 0.812 mL 1.015 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Brucine

Catalog No: CFN90244
CAS No: 357-57-3
Price: $30/20mg
Asiaticoside

Catalog No: CFN99912
CAS No: 16830-15-2
Price: $40/20mg
Tracheloside

Catalog No: CFN90597
CAS No: 33464-71-0
Price: $50/20mg
Furanodienone

Catalog No: CFN92028
CAS No: 24268-41-5
Price: $218/20mg
Polyporenic acid C

Catalog No: CFN92739
CAS No: 465-18-9
Price: $268/10mg
Bakuchalcone

Catalog No: CFN92229
CAS No: 84575-13-3
Price: $ / mg
Glycitin

Catalog No: CFN99105
CAS No: 40246-10-4
Price: $70/20mg
Polyphyllin D

Catalog No: CFN90255
CAS No: 50773-41-6
Price: $118/20mg
8-Prenylnaringenin

Catalog No: CFN92016
CAS No: 53846-50-7
Price: $108/10mg
Retronecine

Catalog No: CFN00322
CAS No: 480-85-3
Price: $ /
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