Dalbergin | CAS:482-83-7 | Manufacturer ChemFaces

Dalbergin

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Description:

Dalbergin exhibits similar bone conserving effect against bone-loss as estradiol treatment, it as a therapeutic candidate against postmenopausal osteoporosis. Dalbergin also prevents some effects of photoaging and maintain skin integrity by regulating the degradation of the extracellular matrix proteins.

Targets:

Nrf2 | NF-kB

In vitro:

Drug Dev Res. 2015 Jan 25

Dalbergia odorifera Extract Ameliorates UVB-Induced Wrinkle Formation by Modulating Expression of Extracellular Matrix Proteins.[Pubmed: 25620496]

Preclinical Research Emerging evidence suggests that Dalbergia odorifera T. Chen (Leguminosae), an indigenous medicinal herb, has therapeutic potential.
METHODS AND RESULTS:
This study examined the antiwrinkle effects of ethanol extracts of D. odorifera in UVB-irradiated human skin cells. Ethanol extracts of D. odorifera and thier constituents, Dalbergin and sativanone, induced expression of collagen type I and transforming growth factor (TGF)-β1 in human dermal fibroblasts. In HR-1 hairless mice exposed to UVB, the ethanol extract reduced wrinkle formation and skin thickness. This inhibitory effect of ethanol extract was associated with the restoration of collagen type I, TGF-β1, and elastin to levels approaching those in skin tissues not exposed to UVB, which was accompanied by the reduction of matrix metalloproteinase-2 and upregulation of tissue inhibitors of metalloproteinase (TIMP)-2 and TIMP-3 in skin tissue exposed to UVB.
CONCLUSIONS:
These results suggest that the ethanol extracts prevent some effects of photoaging and maintain skin integrity by regulating the degradation of the extracellular matrix proteins.

Dalbergin Description

Source:	The heartwoods of Dalbergia sissoo.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Biomed Pharmacother. 2016 Oct;83:942-957.

Fast and long acting neoflavonoids dalbergin isolated from Dalbergia sissoo heartwood is osteoprotective in ovariectomized model of osteoporosis: Osteoprotective effect of Dalbergin.[Pubmed: 27522257 ]

METHODS AND RESULTS:
This study aims to evaluate the skeletal effects of Dalbergin (DBN), isolated from Dalbergia sissoo heartwood, in ovariectomized (OVx) BALB/c mice, a postmenopausal osteoporosis model of bone loss. Treatment with DBN prevented trabecular bone loss in cancellous bone in the tibial metaphysis and lumbar vertebra region of the ovariectomized mice. Micro-CT data showed that mice treated with DBN at 1.0mgkg-1day-1 exhibited improved bone micro-architecture that was sustained with decreased expression of bone resorption markers like TRAP and RANK and caused an increase in osteogenic markers like RUNX2, BMP2 and OPG/RANKL ratio compared with OVx+vehicle treated mice. Moreover, DBN treatment induced no uterine estrogenicity and significantly lowered the osteocalcin amount in serum when compared with OVx+V group. DBN reached its maximum concentration (Cmax) 238.49±21.37ngml-1 in serum as early as 1h of administration. Overall, DBN (1.0mgkg-1day-1) treatment exhibited similar bone conserving effect against bone-loss as estradiol treatment.
CONCLUSIONS:
Daily oral administration of DBN for 8 weeks showed significant anabolic effects on bone micro-architectural parameters along with down regulation of bone resorptive markers without compromising safety at uterine level. Therefore, our study provides basis for DBN as a therapeutic candidate against postmenopausal osteoporosis.

Product Name	Dalbergin
Price:
CAS No.:	482-83-7
Catalog No.:	CFN89161
Molecular Formula:	C₁₆H₁₂O₄
Molecular Weight:	268.26 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Powder
Source:	The heartwoods of Dalbergia sissoo.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-osteoporosis Compound Library Anti-photoaging Compound Library Coumarins Compound Library Nrf2 Inhibitor Library NF-kB Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.7277 mL	18.6386 mL	37.2773 mL	74.5545 mL	93.1932 mL
5 mM	0.7455 mL	3.7277 mL	7.4555 mL	14.9109 mL	18.6386 mL
10 mM	0.3728 mL	1.8639 mL	3.7277 mL	7.4555 mL	9.3193 mL
50 mM	0.0746 mL	0.3728 mL	0.7455 mL	1.4911 mL	1.8639 mL
100 mM	0.0373 mL	0.1864 mL	0.3728 mL	0.7455 mL	0.9319 mL

CFN93065	Nordalbergin	482-82-6	254.24	C₁₅H₁₀O₄
CFN89161	Dalbergin	482-83-7	268.26	C₁₆H₁₂O₄
CFN91559	6,7-Dimethoxy-4-phenylcoumarin	1857-05-2	282.3	C₁₇H₁₄O₄
CFN96288	Mesuol	16981-20-7	392.5	C₂₄H₂₄O₅
CFN96845	Alternariol	641-38-3	258.22	C₁₄H₁₀O₅
CFN89090	Alternariol monomethyl ether	23452-05-3	272.25	C₁₅H₁₂O₅
CFN91492	Alternariol-trimethylaether	13872-98-5	300.3	C₁₇H₁₆O₅
CFN89095	4-Hydroxyalternariol 9-methyl ether	959417-17-5	288.25	C₁₅H₁₂O₆