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Daturaolone
Daturaolone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Daturaolone
Price: $390 / 5 mg
CAS No.: 41498-80-0
Catalog No.: CFN94010
Molecular Formula: C30H48O2
Molecular Weight: 440.71 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The herbs of Datura stramonium Linn.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $370 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Daturaolone has potency in reducing the harmful effects or in maintaining the normal hepatic physiological mechanisms in both acute and chronic hepato-toxic induced liver damage in rats. Daturaolone also possesses in vivo anti-inflammatory and antinociceptive potentials, which are supported in silico by an interaction with COXs receptors.
Targets: COX
In vivo:
Evid. Based Complement .Alternat. Med., 2016; 2016: 4098686.
Biological Evaluation and Docking Analysis of Daturaolone as Potential Cyclooxygenase Inhibitor[Reference: WebLink]
This study deals with the isolation of the active constituent(s) from a methanolic extract of Pistacia integerrima J. L. Stewart barks and it was also oriented to evaluate the in vivo and in silico anti-inflammatory activity.
METHODS AND RESULTS:
By NMR and crystallography techniques, we have isolated a triterpenoid identified as Daturaolone (compound 1). This compound showed in vivo a significant and dose dependent (1-30 mg/kg) anti-inflammatory activity on carrageenan induced mouse paw oedema (ED50= 10.1 mg/kg) and on acetic acid-induced writhing responses in mice (ED50= 13.8 mg/kg). In the in vivo experiments, the effect of tested compound was also evaluated in presence of the reference drug diclofenac (1-30 mg/kg). Moreover, in silico analysis of receptor ligand complex shows that compound 1 interacts with cyclooxygenase (COXs) binding sites displaying an interesting interaction with COX-1.
CONCLUSIONS:
These findings suggest that compound 1 isolated from P. integerrima possesses in vivo anti-inflammatory and anti-nociceptive potential, which are supported in silico by an interaction with COXs receptors.
Daturaolone Description
Source: The herbs of Datura stramonium Linn.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2691 mL 11.3453 mL 22.6907 mL 45.3813 mL 56.7266 mL
5 mM 0.4538 mL 2.2691 mL 4.5381 mL 9.0763 mL 11.3453 mL
10 mM 0.2269 mL 1.1345 mL 2.2691 mL 4.5381 mL 5.6727 mL
50 mM 0.0454 mL 0.2269 mL 0.4538 mL 0.9076 mL 1.1345 mL
100 mM 0.0227 mL 0.1135 mL 0.2269 mL 0.4538 mL 0.5673 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Pharmazie. 1996 Aug;51(8):593-5.
Hepato-protective effect of daturaolone isolated from Solanum arundo.[Pubmed: 8794471]

METHODS AND RESULTS:
The triterpene Daturaolone was isolated for the first time from Solanum arundo Mattei. The structure has been elucidated by comparison of MS and 1H NMR spectra with the reported literature data, and was confirmed by 13C NMR.
CONCLUSIONS:
The compound proved its potency in reducing the harmful effects or in maintaining the normal hepatic physiological mechanisms in both acute and chronic hepato-toxic induced liver damage in rats.
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