Science | Nature | Cell | View More
Natural Products
Dehydroevodiamine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Dehydroevodiamine
Price: $50 / 20mg
CAS No.: 67909-49-3
Catalog No.: CFN90944
Molecular Formula: C19H15N3O
Molecular Weight: 301.4 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Yellow powder
Source: The fruits of Evodia rutaecarpa.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $14.4 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • FORTH-IMBB (Greece)
  • Auburn University (USA)
  • Leibniz Institute of Plant Bioc... (Germany)
  • Texas A&M University (USA)
  • University of Illinois at Chicago (USA)
  • Cancer Research Initatives Foun... (Malaysia)
  • Hamdard University (India)
  • The Institute of Cancer Research (United Kingdom)
  • University of Lodz (Poland)
  • Centralised Purchases Unit (CPU... (India)
  • Korea Institute of Oriental Med... (Korea)
  • More...
Package
Featured Products
Hypaphorine

Catalog No: CFN90634
CAS No: 487-58-1
Price: $80/20mg
Oroxin A

Catalog No: CFN99712
CAS No: 57396-78-8
Price: $128/20mg
Zingerone

Catalog No: CFN99702
CAS No: 122-48-5
Price: $30/20mg
Hotrienol

Catalog No: CFN99583
CAS No: 20053-88-7
Price: $ / mg
Procyanidin A2

Catalog No: CFN96491
CAS No: 41743-41-3
Price: $238/10mg
Clinopodiside A

Catalog No: CFN90479
CAS No: 142809-89-0
Price: $122/20mg
Nothofagin

Catalog No: CFN92888
CAS No: 11023-94-2
Price: $ / mg
Rebaudioside A

Catalog No: CFN99110
CAS No: 58543-16-1
Price: $40/20mg
Bavachin

Catalog No: CFN98007
CAS No: 19879-32-4
Price: $40/20mg
Europine

Catalog No: CFN00264
CAS No: 570-19-4
Price: $ /
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Dehydroevodiamine has anticholinesterase activity and an anti-amnesic effect, it also may be a novel and effective ligand for improvement of beta-amyloid type amnesia. Dehydroevodiamine has antiarrhythmic, and anti-inflammatory properties, the effect of dehydroevodiamine-mediated inhibition of the expression LPS-induced iNOS and COX-2 genes is due to under the suppression of NF-kappaB activation in the transcriptional level.
Targets: Beta Amyloid | NOS | COX | PGE | NF-kB
In vitro:
J Ethnopharmacol. 2014 May 14;153(3):753-62.
Antiarrhythmic effects of dehydroevodiamine in isolated human myocardium and cardiomyocytes.[Pubmed: 24680993 ]
Dehydroevodiamine alkaloid (DeHE), a bioactive component of the Chinese herbal medicine Wu-Chu-Yu (Evodiae frutus), exerted antiarrhythmic effect in guinea-pig ventricular myocytes. We further characterize the electromechanical effects of DeHE in the human atrial and ventricular tissues obtained from hearts of patients undergoing corrective cardiac surgery or heart transplantation.
METHODS AND RESULTS:
The transmembrane potentials of human myocardia were recorded with a traditional microelectrode technique while sarcolemmal Na(+) and Ca(2+) currents in single human cardiomyocytes were measured by a whole-cell patch-clamp technique. The intracellular pH (pHi) and Na(+)-H(+) exchanger (NHE) activity were determined using BCECF-fluorescence in human atria. In human atria, DeHE (0.1-0.3 μM) depressed upstroke velocity, amplitude of action potential, and contractile force, both in slow and fast response action potential. Moreover, the similar depressant effects of DeHE were found in human ventricular myocardium. Both in isolated human atrial and ventricular myocytes, DeHE (0.1-1 μM) reversibly, concentration-dependently decreased the Na(+) and Ca(2+)currents. Moreover, DeHE (0.1 and 0.3 μM) suppressed delayed afterdepolarizations and aftercontractions, induced by epinephrine and high [Ca(2+)]o in atria. In human ventricular myocardium, the strophanthidin-induced triggered activities were attenuated by pretreating DeHE (0.3 μM). The resting pHi and NHE activity were also significantly increased by DeHE (0.1-0.3 μM).
CONCLUSIONS:
We concluded for the first time that, in the human hearts, DeHE could antagonize triggered arrhythmias induced by cardiotonic agents through a general reduction of the Na(+) and Ca(2+) inward currents, while increase of resting pHi and NHE activity.
In vivo:
Eur J Pharmacol. 2001 Feb 16;413(2-3):221-5.
Dehydroevodiamine attenuates beta-amyloid peptide-induced amnesia in mice.[Pubmed: 11226396]
Dehydroevodiamine has been reported to have anticholinesterase activity and an anti-amnesic effect.
METHODS AND RESULTS:
This study examined the effects of Dehydroevodiamine on scopolamine- and beta-amyloid peptide-(25--35)-induced amnesia in mice, using a step-through passive avoidance test. Similarly to the cholinesterase inhibitor, physostigmine (0.03--0.3 mg/kg, i.p.), Dehydroevodiamine (0.75--12.0 mg/kg, i.p.) administered 30 min before the training trial, immediately after the training trial, and 30 min before the retention test significantly improved scopolamine- and beta-amyloid peptide-(25--35)-induced amnesia. In beta-amyloid peptide-(25--35)-induced amnesia, the rank order of anti-amnesic potency in these three administration schedules for Dehydroevodiamine was different from that for physostigmine. Furthermore, Dehydroevodiamine was more potent to improve beta-amyloid peptide-(25--35)-induced amnesia than scopolamine-induced amnesia when administered before the training trial.
CONCLUSIONS:
These results suggested that Dehydroevodiamine may have an action other than that of an anticholinesterase and may be a novel and effective ligand for improvement of beta-amyloid type amnesia.
Dehydroevodiamine Description
Source: The fruits of Evodia rutaecarpa.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Cajanine

Catalog No: CFN95448
CAS No: 87402-84-4
Price: $318/5mg
Crepidiaside B

Catalog No: CFN95432
CAS No: 101921-35-1
Price: $318/10mg
Safflospermidine B

Catalog No: CFN95254
CAS No: N/A
Price: $413/5mg
Gynosaponin TN2

Catalog No: CFN95331
CAS No: 77658-95-8
Price: $318/5mg
Verbasoside

Catalog No: CFN95015
CAS No: 61548-34-3
Price: $318/5mg
(-)-Epiafzelechin 3-O-gallate

Catalog No: CFN95081
CAS No: 108907-43-3
Price: $388/5mg
Methyl lucidenate G

Catalog No: CFN95058
CAS No: 102607-20-5
Price: $413/5mg
Formononetin-8-C-beta-D-apiofurano...

Catalog No: CFN95157
CAS No: 1147858-78-3
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.3179 mL 16.5893 mL 33.1785 mL 66.357 mL 82.9463 mL
5 mM 0.6636 mL 3.3179 mL 6.6357 mL 13.2714 mL 16.5893 mL
10 mM 0.3318 mL 1.6589 mL 3.3179 mL 6.6357 mL 8.2946 mL
50 mM 0.0664 mL 0.3318 mL 0.6636 mL 1.3271 mL 1.6589 mL
100 mM 0.0332 mL 0.1659 mL 0.3318 mL 0.6636 mL 0.8295 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Cell Research:
Life Sci. 2006 Jul 10;79(7):695-701.
Inhibition of lipopolysaccharide-induced iNOS and COX-2 expression by dehydroevodiamine through suppression of NF-kappaB activation in RAW 264.7 macrophages.[Pubmed: 16554073 ]
Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus.
METHODS AND RESULTS:
We investigated the anti-inflammatory properties of Dehydroevodiamine in RAW 264.7 murine macrophages. The results indicated that Dehydroevodiamine inhibited the expression of LPS-induced iNOS and COX-2 proteins and suppressed also their mRNAs from RT-PCR experiment on RAW 264.7 cells. Furthermore, this compound inhibited the level of LPS-stimulated prostaglandin E2 (PGE2) and LPS-induced nuclear factor-kappa B (NF-kappaB).
CONCLUSIONS:
Therefore, we suggested that the effect of Dehydroevodiamine-mediated inhibition of the expression LPS-induced iNOS and COX-2 genes is due to under the suppression of NF-kappaB activation in the transcriptional level.
Hypaphorine

Catalog No: CFN90634
CAS No: 487-58-1
Price: $80/20mg
Oroxin A

Catalog No: CFN99712
CAS No: 57396-78-8
Price: $128/20mg
Zingerone

Catalog No: CFN99702
CAS No: 122-48-5
Price: $30/20mg
Hotrienol

Catalog No: CFN99583
CAS No: 20053-88-7
Price: $ / mg
Procyanidin A2

Catalog No: CFN96491
CAS No: 41743-41-3
Price: $238/10mg
Clinopodiside A

Catalog No: CFN90479
CAS No: 142809-89-0
Price: $122/20mg
Nothofagin

Catalog No: CFN92888
CAS No: 11023-94-2
Price: $ / mg
Rebaudioside A

Catalog No: CFN99110
CAS No: 58543-16-1
Price: $40/20mg
Bavachin

Catalog No: CFN98007
CAS No: 19879-32-4
Price: $40/20mg
Europine

Catalog No: CFN00264
CAS No: 570-19-4
Price: $ /
Tags: buy Dehydroevodiamine | Dehydroevodiamine supplier | purchase Dehydroevodiamine | Dehydroevodiamine cost | Dehydroevodiamine manufacturer | order Dehydroevodiamine | Dehydroevodiamine distributor