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Delaminomycin A
Delaminomycin A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Delaminomycin A
Price:
CAS No.: 149779-38-4
Catalog No.: CFN00113
Molecular Formula: C29H43NO6
Molecular Weight: 501.66 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: From Streptomyces albulus
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Delaminomycin A is an immunomodulator, it is a cell adhesion inhibitor and extracellular matrix receptor antagonist. Delaminomycin A is active against gram-positive bacteria.
Targets: Immunology & Inflammation related
In vitro:
J Antibiot (Tokyo). 1993 Jul;46(7):1156-62.
Delaminomycins, novel extracellular matrix receptor antagonist. IV. Structure-activity relationships of delaminomycins and derivatives.[Pubmed: 8360111]
Delaminomycin A, Delaminomycin B, Delaminomycin C and their derivatives were prepared and investigated biological activities of them.
METHODS AND RESULTS:
Among these compounds, spiro compounds (A2, B2 and C2) showed stronger inhibitory activity than natural products (A1, B1 and C1) on B16 melanoma cells adhesion assay and Con A-induced proliferation of murine splenic lymphocytes assay. In MLCR and antimicrobial assay, however, A1, B1 and C1 showed more potent inhibitory activity than spiro compounds (A2, B2 and C2). On the other hand, as to C-5' substituents of pyrrolidine ring, the order of inhibitory activity was R = OH > R = OCH3 > R = H on Con A-induced proliferation of murine splenic lymphocytes assay. In MLCR and antimicrobial assay, however, the order of inhibitory activities were R = H > R = OCH3 > R = OH.
CONCLUSIONS:
Inhibitory activities of A4 which was lacked pyrrolidine ring were reduced on B16 melanoma cells adhesion assay and on cytotoxicity against tumor cells in vitro in comparison with those of A1.
Delaminomycin A Description
Source: From Streptomyces albulus
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
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doi: 10.1021/acsnano.7b08969.
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PMID: 29553709

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.9934 mL 9.9669 mL 19.9338 mL 39.8676 mL 49.8345 mL
5 mM 0.3987 mL 1.9934 mL 3.9868 mL 7.9735 mL 9.9669 mL
10 mM 0.1993 mL 0.9967 mL 1.9934 mL 3.9868 mL 4.9835 mL
50 mM 0.0399 mL 0.1993 mL 0.3987 mL 0.7974 mL 0.9967 mL
100 mM 0.0199 mL 0.0997 mL 0.1993 mL 0.3987 mL 0.4983 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Antibiot (Tokyo). 1993 Jun;46(6):979-84.
Delaminomycins, novel nonpeptide extracellular matrix receptor antagonist and a new class of potent immunomodulator. II. Physico-chemical properties and structure elucidation of delaminomycin A.[Pubmed: 8393852]

METHODS AND RESULTS:
Delaminomycins, novel extracellular matrix receptor antagonists, have been isolated from a culture broth of Streptomyces albulus MJ202-72F3. The structure of Delaminomycin A was determined to be 3-[[2-[(3E,5E)-2,8-dihydroxy-7-methyl-3,5-decadienyl]- 1,6,8- trimethyl-1,2,4a,5,6,7,8,8a-octahydro-1-naphthyl]carbonyl]-5- hydroxypyrrolidine-2,4-dione by analyses of spectral properties and chemical studies.
US 5527820 A[P]. 1996.
Antibiotics having immunosuppressive activity, delaminomycins and processes for the production of the same[Reference: WebLink]
As new antibiotics are obtained delaminomycins A, B and C having a formula (I) or (I') shown below, or salts thereof.
METHODS AND RESULTS:
Delaminomycins preferentially inhibit T cells and are useful as immunosuppressants, antineoplastic agents and antibacterial agents. ##STR1## wherein X is a hydroxyl group for Delaminomycin A, a methoxy group for delaminomycin B and a hydrogen atom for delaminomycin C.
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