Science | Nature | Cell | View More
Natural Products
Dihydromethysticin
Dihydromethysticin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Dihydromethysticin
Price:
CAS No.: 19902-91-1
Catalog No.: CFN90332
Molecular Formula: C15H16O5
Molecular Weight: 276.28 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Cryst.
Source: The herbs of Piper methysticum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Pretoria (South Africa)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Institute of Pathophysiology Me... (Austria)
  • Universidade Federal de Pernamb... (Brazil)
  • Chungnam National University (Korea)
  • Utrecht University (Netherlands)
  • University of Bonn (Germany)
  • Universidade Católica Portuguesa (Portugal)
  • University of Minnesota (USA)
  • Northeast Normal University Cha... (China)
  • Julius Kühn-Institut (Germany)
  • More...
Package
Featured Products
Brevilin A

Catalog No: CFN99694
CAS No: 16503-32-5
Price: $128/20mg
Gelsemine

Catalog No: CFN99001
CAS No: 509-15-9
Price: $218/20mg
Geissoschizine methyl ether

Catalog No: CFN89459
CAS No: 60314-89-8
Price: $268/10mg
Sanguinarine

Catalog No: CFN98259
CAS No: 2447-54-3
Price: $30/20mg
Gallocatechin gallate

Catalog No: CFN96488
CAS No: 5127-64-0
Price: $100/5mg
Crocin II

Catalog No: CFN99928
CAS No: 55750-84-0
Price: $118/20mg
Echinacoside

Catalog No: CFN98105
CAS No: 82854-37-3
Price: $30/20mg
Dendrobine

Catalog No: CFN99133
CAS No: 2115-91-5
Price: $188/20mg
(-)-Epigallocatechin(EGC)

Catalog No: CFN97549
CAS No: 970-74-1
Price: $40/20mg
Carnosol

Catalog No: CFN99956
CAS No: 5957-80-2
Price: $80/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Dihydromethysticin non-competitively inhibits the specific binding of [3H]-batrachotoxinin-A 20-alpha-benzoate to receptor site 2 of voltage-gated Na+ channels.The induction of CYP3A23 by dihydromethysticin and desmethoxyyangonin involves transcription activation, probably through a pregnane X receptor (PXR).-independent or PXR-involved indirect mechanism.
Targets: Sodium Channel | P450 (e.g. CYP17)
In vitro:
Drug Metab Dispos. 2004 Nov;32(11):1317-24.
Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23.[Pubmed: 15282211]
Kava kava (Piper methysticum), an herbal remedy, is widely used for the treatment of mild to moderate cases of anxiety. The therapeutic activity is presumably achieved through multiple constituents called kavalactones. Recently, kava extracts were shown to induce CYP3A4 and activate human pregnane X receptor (PXR).
METHODS AND RESULTS:
This study was undertaken to test the ability of purified kavalactones to induce CYP3A23 and activate PXR. Rat hepatocytes were treated with desmethoxyyangonin, dihydrokawain, Dihydromethysticin, kawain, methysticin, or yangonin, and the expression of CYP3A23 was monitored. Among the kavalactones, only desmethoxyyangonin and Dihydromethysticin markedly induced the expression of CYP3A23 (approximately 7-fold). A similar magnitude of induction was detected with combined six kavalactones at a noninductive concentration when individually used. The induced expression, however, was markedly reduced or completely abolished if Dihydromethysticin, desmethoxyyangonin, or both were excluded from the mixtures. Interestingly, regardless of whether Dihydromethysticin or desmethoxyyangonin was used alone or together with other kavalactones, similar amounts of total kavalactones were needed to produce comparable induction, suggesting that the inductive activity of Dihydromethysticin and desmethoxyyangonin is additively/synergistically enhanced by other kavalactones. In addition, treatment with Dihydromethysticin, desmethoxyyangonin, or pregnenolone 16alpha-carbonitrile (PCN) markedly increased the levels of CYP3A23 mRNA, and inhibition of mRNA synthesis abolished the induction. In contrast to PCN, Dihydromethysticin and desmethoxyyangonin only slightly activated rat or human PXR.
CONCLUSIONS:
These findings suggest that the induction of CYP3A23 by Dihydromethysticin and desmethoxyyangonin involves transcription activation, probably through a PXR-independent or PXR-involved indirect mechanism.
Dihydromethysticin Description
Source: The herbs of Piper methysticum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Scoparin

Catalog No: CFN95544
CAS No: 301-16-6
Price: $318/5mg
2-Phenylethyl-beta-glucopyranoside

Catalog No: CFN95429
CAS No: 18997-54-1
Price: $318/10mg
3',5-Dihydroxy-4',6,7-trimethoxyfl...

Catalog No: CFN95316
CAS No: 90850-99-0
Price: $318/5mg
Dihydrophaseic acid 4'-O-beta-D-gl...

Catalog No: CFN95393
CAS No: 78914-56-4
Price: $318/5mg
Methyl ganoderenate B

Catalog No: CFN95534
CAS No: N/A
Price: $413/5mg
Norwogonin-8-O-glucuronide

Catalog No: CFN95423
CAS No: 118525-47-6
Price: $368/5mg
Citrusin B

Catalog No: CFN95178
CAS No: 105279-10-5
Price: $388/5mg
5-Hydroxy-1-(4-hydroxyphenyl)-7-ph...

Catalog No: CFN95137
CAS No: 105955-04-2
Price: $268/20mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.6195 mL 18.0976 mL 36.1952 mL 72.3903 mL 90.4879 mL
5 mM 0.7239 mL 3.6195 mL 7.239 mL 14.4781 mL 18.0976 mL
10 mM 0.362 mL 1.8098 mL 3.6195 mL 7.239 mL 9.0488 mL
50 mM 0.0724 mL 0.362 mL 0.7239 mL 1.4478 mL 1.8098 mL
100 mM 0.0362 mL 0.181 mL 0.362 mL 0.7239 mL 0.9049 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Planta Med. 1998 Jun;64(5):458-9.
Kavain, dihydrokavain, and dihydromethysticin non-competitively inhibit the specific binding of [3H]-batrachotoxinin-A 20-alpha-benzoate to receptor site 2 of voltage-gated Na+ channels.[Pubmed: 9690349 ]

METHODS AND RESULTS:
The mode of action of the kava pyrones, kavain, dihydrokavain and Dihydromethysticin on the specific binding of [3H]-batrachotoxinin-A 20-alpha-benzoate to epitope 2 of voltage-dependent Na+ channels was investigated by performing saturation experiments in the presence and absence of these kava pyrones. The tested compounds significantly decreased the apparent total number of binding sites (Bmax) for [3H]-batrachotoxinin-A 20-alpha-benzoate (control: 0.5 pmol/mg protein, kava pyrones: 0.2-0.27 pmol/mg protein) with little change in the equilibrium constants (KD) for [3H]-batrachotoxin-A 20-alpha-benzoate (control: 28.2 nM, kava pyrones: 24-31 nM).
CONCLUSIONS:
The results indicate for the kava pyrones a non-competitive inhibition of the specific [3H]-batrachotoxinin-A 20-alpha-benzoate binding to receptor site 2 of voltage-gated Na+ channels.
Brevilin A

Catalog No: CFN99694
CAS No: 16503-32-5
Price: $128/20mg
Gelsemine

Catalog No: CFN99001
CAS No: 509-15-9
Price: $218/20mg
Geissoschizine methyl ether

Catalog No: CFN89459
CAS No: 60314-89-8
Price: $268/10mg
Sanguinarine

Catalog No: CFN98259
CAS No: 2447-54-3
Price: $30/20mg
Gallocatechin gallate

Catalog No: CFN96488
CAS No: 5127-64-0
Price: $100/5mg
Crocin II

Catalog No: CFN99928
CAS No: 55750-84-0
Price: $118/20mg
Echinacoside

Catalog No: CFN98105
CAS No: 82854-37-3
Price: $30/20mg
Dendrobine

Catalog No: CFN99133
CAS No: 2115-91-5
Price: $188/20mg
(-)-Epigallocatechin(EGC)

Catalog No: CFN97549
CAS No: 970-74-1
Price: $40/20mg
Carnosol

Catalog No: CFN99956
CAS No: 5957-80-2
Price: $80/20mg
Tags: buy Dihydromethysticin | Dihydromethysticin supplier | purchase Dihydromethysticin | Dihydromethysticin cost | Dihydromethysticin manufacturer | order Dihydromethysticin | Dihydromethysticin distributor