Dipotassium Glycyrrhizinate | CAS:68797-35-3

Dipotassium Glycyrrhizinate

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Description:

Dipotassium glycyrrhizinate is an anionic surfactant having anti-allergic and anti-inflammatory activities.

In vitro:

Int J Pharm. 2002 Jul 25;241(2):319-27.

Elastic liposomes for skin delivery of dipotassium glycyrrhizinate.[Pubmed: 12100859]

The aim of this study was to evaluate the possibility of using liposomes for skin delivery of Dipotassium Glycyrrhizinate (KG), an anti-inflammatory agent employed in treating acute and chronic dermatitis, and of formulating such liposomes in an oil-in-water emulsion (O/W). KG had emulsifying properties and the possibility of producing elastic liposomes was verified.
METHODS AND RESULTS:
Liposomes containing soya lecithin (PC) or hydrogenated soya lecithin (HPC) mixed with KG in w/w ratios of 2:1, 4:1 or 8:1 were prepared by the solvent evaporation method and then passed through a high pressure homogeniser. Liposome size and entrapment efficiency were determined and the interaction between KG and HPC was investigated using differential scanning calorimetry (DSC). Transepidermal permeation through intact pig skin and skin deposition of KG from liposomes and O/W emulsion containing liposomes were assessed and compared with values for aqueous control solutions. No marked differences were observed between PC and HPC liposomes. Liposome sizes ranged from 90 to 120 nm. Entrapment efficiency depended on the lipid:KG ratio; the maximum efficiency was obtained at 4:1 w/w. KG interacted with liposomes disrupting and fluidising the lipid bilayer, forming elastic liposomes able to penetrate through membrane pores of diameter much smaller than their own diameter. The liposome structure was maintained when dispersed in an O/W emulsion.
CONCLUSIONS:
The skin fluxes were less than the HPLC detection limit for all systems, while skin deposition increased 4.5-fold compared with aqueous solutions when KG was formulated in liposomes.

Dipotassium Glycyrrhizinate Description

Source:	The roots of Glycyrrhiza glabra.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Dipotassium Glycyrrhizinate
Price:
CAS No.:	68797-35-3
Catalog No.:	CFN93273
Molecular Formula:	C₄₂H₆₂K₂O₁₇
Molecular Weight:	917.13 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The roots of Glycyrrhiza glabra.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Triterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.0904 mL	5.4518 mL	10.9036 mL	21.8072 mL	27.2589 mL
5 mM	0.2181 mL	1.0904 mL	2.1807 mL	4.3614 mL	5.4518 mL
10 mM	0.109 mL	0.5452 mL	1.0904 mL	2.1807 mL	2.7259 mL
50 mM	0.0218 mL	0.109 mL	0.2181 mL	0.4361 mL	0.5452 mL
100 mM	0.0109 mL	0.0545 mL	0.109 mL	0.2181 mL	0.2726 mL

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