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Dodoviscin A
Dodoviscin A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Dodoviscin A
Price:
CAS No.: 1372527-25-7
Catalog No.: CFN96016
Molecular Formula: C27H32O9
Molecular Weight: 500.6 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow powder
Source: The herbs of Dodonaea viscosa
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Dodoviscin A may be a new promising pigmentation-altering agent for cosmetic and therapeutic applications, it can inhibit melanin biosynthesis induced by 3-isobutyl-1-methylxanthine and PD98059.Dodoviscin A can promote adipocyte differentiation as characterized by increased triglyceride levels in 3T3L1 cells, it can enhance the accumulation of lipid droplets and induce upregulation of the expression of the adipocyte-specific genes aP2 and GLUT4.
Targets: cAMP | GLUT | Tyrosinase
In vitro:
Planta Med. 2013 Jul;79(11):933-8.
Dodoviscin a inhibits melanogenesis in mouse b16-f10 melanoma cells.[Pubmed: 23804039]
Nowadays, abnormal hyperpigmentation in human skin such as melasma, freckles, and chloasma has become a serious esthetic problem. Cutaneous depigmenting agents could be used to treat these hyperpigmentation-associated dieseases. Dodoviscin A is a natural product isolated from the aerial parts of Dodonaea viscosa. In the present study, we evaluated the effect of Dodoviscin A on melanin production in B16-F10 melanoma cells for the first time.
METHODS AND RESULTS:
We found that Dodoviscin A inhibited melanin biosynthesis induced by 3-isobutyl-1-methylxanthine and PD98059 significantly, and there was no obvious effect on the viability of Dodoviscin A-treated B16-F10 cells. Meanwhile, Dodoviscin A could suppress the activity of mushroom tyrosinase in the cell-free assay system and also decrease 3-isobutyl-1-methylxanthine-induced tyrosinase activity and expression of mature tyrosinase protein in B16-F10 cells. Western blotting analysis showed that Dodoviscin A inhibited 3-isobutyl-1-methylxanthine and forskolin-induced phosphorylation of the cAMP response element binding protein in B16-F10 cells.
CONCLUSIONS:
These results indicate that Dodoviscin A may be a new promising pigmentation-altering agent for cosmetic and therapeutic applications.
J Nat Prod. 2012 Apr 27;75(4):699-706.
Isoprenylated flavonoid and adipogenesis-promoting constituents of Dodonaea viscosa.[Pubmed: 22512738]

METHODS AND RESULTS:
Ten new isoprenylated flavonol derivatives, Dodoviscin A, dodoviscins B -J (1-10), and seven known compounds (11-17) were isolated from the aerial parts of Dodonaea viscosa. Compounds 1, 2, 4, 5, 7-9, 5,7,4'-trihydroxy-3',5'-bis(3-methyl-2-buten-1-yl)-3-methoxyflavone (11), 5,7,4'-trihydroxy-3',5'-bis(3-methyl-2-buten-1-yl)-3,6-dimethoxyflavone (12), 5,7,4'-trihydroxy-3'-(4-hydroxy-3-methylbutyl)-5'-(3-methyl-2-buten-1-yl)-3,6-dimethyoxyflavone (13), sakuranetin (14), and blumeatin (15) promoted adipocyte differentiation as characterized by increased triglyceride levels in 3T3L1 cells.
CONCLUSIONS:
Compounds 1, 13, and 15 also enhanced the accumulation of lipid droplets and induced upregulation of the expression of the adipocyte-specific genes aP2 and GLUT4.
Dodoviscin A Description
Source: The herbs of Dodonaea viscosa
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.9976 mL 9.988 mL 19.976 mL 39.9521 mL 49.9401 mL
5 mM 0.3995 mL 1.9976 mL 3.9952 mL 7.9904 mL 9.988 mL
10 mM 0.1998 mL 0.9988 mL 1.9976 mL 3.9952 mL 4.994 mL
50 mM 0.04 mL 0.1998 mL 0.3995 mL 0.799 mL 0.9988 mL
100 mM 0.02 mL 0.0999 mL 0.1998 mL 0.3995 mL 0.4994 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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