Echitamine | CAS:6871-44-9 | Manufacturer ChemFaces

Echitamine

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Description:

Echitamine chloride possesses anti-tumour activity in-vitro and in-vivo.

In vivo:

J Pharm Pharmacol. 2005 Sep;57(9):1213-9.

Evaluation of the cytotoxic effect of the monoterpene indole alkaloid echitamine in-vitro and in tumour-bearing mice.[Pubmed: 16105243]

The cytotoxic effect of various concentrations of Echitamine chloride was studied in HeLa, HepG2, HL60, KB and MCF-7 cell lines in-vitro and in mice bearing Ehrlich ascites carcinoma (EAC).
METHODS AND RESULTS:
Exposure of various cells to different concentrations of Echitamine chloride resulted in a concentration-dependent cell killing, and KB cells were found to be most sensitive amongst all the cells evaluated. EAC mice treated with 1, 2, 4, 6, 8, 12 or 16 mg kg-1 Echitamine chloride showed a dose-dependent elevation in the anti-tumour activity, as evident by increased number of survivors in comparison with the non-drug treated controls. The highest dose of Echitamine chloride (16 mg kg-1) caused toxicity in the recipient mice, therefore 12 mg kg-1 was considered the best cytotoxic dose for its anti-tumour effect. Administration of 12 mg kg-1 Echitamine chloride resulted in an increase in the median survival time (MST) up to 30.5 days, which was 11.5 days higher than the non-drug treated control (19 days). Administration of 16 mg kg-1 Echitamine chloride to EAC mice resulted in a time dependent elevation in lipid peroxidation that reached a peak at 6 h post-treatment, whereas glutathione concentration declined in a time dependent manner and a maximum decline was reported at 3 h post-treatment.
CONCLUSIONS:
Our study demonstrated that Echitamine chloride possessed anti-tumour activity in-vitro and in-vivo.

Echitamine Description

Source:	The herbs of Alstonia scholaris
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Echitamine
Price:
CAS No.:	6871-44-9
Catalog No.:	CFN97168
Molecular Formula:	C₂₂H₂₉N₂O₄
Molecular Weight:	385.5 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Alstonia scholaris
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.594 mL	12.9702 mL	25.9403 mL	51.8807 mL	64.8508 mL
5 mM	0.5188 mL	2.594 mL	5.1881 mL	10.3761 mL	12.9702 mL
10 mM	0.2594 mL	1.297 mL	2.594 mL	5.1881 mL	6.4851 mL
50 mM	0.0519 mL	0.2594 mL	0.5188 mL	1.0376 mL	1.297 mL
100 mM	0.0259 mL	0.1297 mL	0.2594 mL	0.5188 mL	0.6485 mL

CFN99260	N1-Methoxymethyl picrinine	1158845-78-3	382.5	C₂₂H₂₆N₂O₄
CFN97014	N-Demethylechitamine	60048-88-6	370.5	C₂₁H₂₆N₂O₄
CFN97168	Echitamine	6871-44-9	385.5	C₂₂H₂₉N₂O₄
CFN97900	Akuammiline	1897-26-3	394.5	C₂₃H₂₆N₂O₄
CFN96687	Rauvoyunine B	1414883-82-1	426.46	C₂₃H₂₆N₂O₆
CFN97938	Alstolenine	85769-33-1	546.6	C₃₁H₃₄N₂O₇
CFN97888	Picraline	2671-32-1	410.5	C₂₃H₂₆N₂O₅
CFN97966	Rauvoyunine C	1211543-01-9	592.7	C₃₂H₃₆N₂O₉
CFN97942	Pseudoakuammigine	2447-70-3	366.5	C₂₂H₂₆N₂O₃
CFN98013	Picralinal	20045-06-1	366.4	C₂₁H₂₂N₂O₄