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    (-)-Epigallocatechin gallate
    Information
    CAS No. 989-51-5 Price $50 / 20mg
    Catalog No.CFN99569Purity>=98%
    Molecular Weight458.38Type of CompoundFlavonoids
    FormulaC22H18O11Physical DescriptionWhite powder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)
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    (-)-Epigallocatechin gallate Description
    Source: The wood of Acacia catechu (L.F.) Willd.
    Biological Activity or Inhibitors: 1. (-)-Epigallocatechin gallate (EGCG), a green tea polyphenol that reduce Aβ aggregation, inhibits the aggregation of tau K18ΔK280 into toxic oligomers at ten- to hundred-fold substoichiometric concentrations, thereby rescuing toxicity in neuronal model cells.
    2. (-)-Epigallocatechin gallate treatment enduring to cardio protection at mitochondrial level.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1816 mL 10.908 mL 21.816 mL 43.6319 mL 54.5399 mL
    5 mM 0.4363 mL 2.1816 mL 4.3632 mL 8.7264 mL 10.908 mL
    10 mM 0.2182 mL 1.0908 mL 2.1816 mL 4.3632 mL 5.454 mL
    50 mM 0.0436 mL 0.2182 mL 0.4363 mL 0.8726 mL 1.0908 mL
    100 mM 0.0218 mL 0.1091 mL 0.2182 mL 0.4363 mL 0.5454 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    (-)-Epigallocatechin gallate References Information
    Citation [1]

    Mol Biol Rep. 2013 Dec;40(12):6533-45.

    (-)-Epigallocatechin-gallate (EGCG) stabilize the mitochondrial enzymes and inhibits the apoptosis in cigarette smoke-induced myocardial dysfunction in rats.[Pubmed: 24197690]
    The present study brings out the preventive role of (-)-Epigallocatechin gallate (EGCG) on cardiac mitochondrial metabolism and apoptosis in cigarette smoke (CS)-exposed rats. The CS-exposed rats showed significantly decreased activities of TCA cycle enzymes and mitochondrial enzymatic antioxidants, on the other hand, mitochondrial lipid peroxidation was increased and GSH level was decreased. Further, CS exposure was found to induce cardiac apoptosis through release of cytochrome c into the cytosol, cleavage of pro-caspase-3 to active caspase-3, up-regulation of pro-apoptotic (Bax) and down-regulation of antiapoptotic (Bcl-2) molecules. The CS-induced apoptosis was further confirmed by mitochondrial and nuclear ultra structural apoptotic features as evaluated by electron microscopic studies. (-)-Epigallocatechin gallate supplementation shelters the activities of TCA cycle enzymes and antioxidant enzymes, with concomitant decrease in lipid peroxidation and increase in GSH level. (-)-Epigallocatechin gallate administration inhibited apoptosis through the inhibition of cytochrome c release into cytosol, activation of pro-caspase-3, down regulation of Bax and significant up regulation of Bcl-2. (-)-Epigallocatechin gallate reversed the ultra structural apoptotic alterations of mitochondria and nucleus. The present study has provided experimental evidences that the (-)-Epigallocatechin gallate treatment enduring to cardio protection at mitochondrial level.
    Citation [2]

    FEBS Lett. 2015 Jan 2;589(1):77-83.

    The green tea polyphenol (-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios.[Pubmed: 25436420]
    The accumulation of amyloid-beta (Aβ) and tau aggregates is a pathological hallmark of Alzheimer's disease. Both polypeptides form fibrillar deposits, but several lines of evidence indicate that Aβ and tau form toxic oligomeric aggregation intermediates. Depleting such structures could thus be a powerful therapeutic strategy. We generated a fragment of tau (His-K18ΔK280) that forms stable, toxic, oligomeric tau aggregates in vitro. We show that (-)-Epigallocatechin gallate (EGCG), a green tea polyphenol that was previously found to reduce Aβ aggregation, inhibits the aggregation of tau K18ΔK280 into toxic oligomers at ten- to hundred-fold substoichiometric concentrations, thereby rescuing toxicity in neuronal model cells.
    Citation [3]

    Food Chem. 2015 Apr 15;173:564-8.

    Physicochemical characterisation of β-carotene emulsion stabilised by covalent complexes of α-lactalbumin with (-)-epigallocatechin gallate or chlorogenic acid.[Pubmed: 25466060]
    In this study the impact of covalent complexes of α-lactalbumin (α-La) with (-)-Epigallocatechin gallate (EGCG) or chlorogenic acid (CA) was investigated on the physicochemical properties of β-carotene oil-in-water emulsions. (-)-Epigallocatechin gallate, or CA, was covalently linked to α-La at pH 8.0, as evidenced by increased total phenolic content and declined fluorescence intensity. Compared with those stabilised by α-La alone and α-La-CA or (-)-Epigallocatechin gallate mixture, the emulsion stabilised by the α-La-(-)-Epigallocatechin gallate covalent complex exhibited the least changes in particle size and transmission profiles, using a novel centrifugal sedimentation technique, indicating an improvement in the physical stability. The least degradation of β-carotene occurred in the emulsion stabilised with the α-La-(-)-Epigallocatechin gallate covalent complex when stored at 25 °C. These results implied that protein-polyphenol covalent complexes were able to enhance the physical stability of β-carotene emulsion and inhibit the degradation of β-carotene in oil-in-water emulsion, and the effect was influenced by the types of the phenolic compounds.