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Epitaraxerol
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Product Name Epitaraxerol
Price:
CAS No.: 20460-33-7
Catalog No.: CFN97789
Molecular Formula: C30H50O
Molecular Weight: 426.73 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The herbs of Euphorbia chrysocoma
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Epitaraxerol shows moderate antifungal activity against C. albicans and low antimicrobial activity against T. mentagrophytes, A. niger, S. aureus, E. coli, P. aeruginosa, and B. subtilis.
Targets: Antifection
In vitro:
Pharmacognosy Journal, 2012, 4(31):1-4.
Chemical constituents of Broussonetia luzonicus[Reference: WebLink]

METHODS AND RESULTS:
The leaves of Broussonetia luzonicus afforded Epitaraxerol (1), lupenone (2), squalene (3), β-carotene (4), vitamin K (5) and β-sitosterol (6), while the flowers yielded 2, 6, lupeol (7), betulin aldehyde fatty acid ester (8) and lupeol fatty acid ester (9). The compounds were isolated by silica gel chromatography and identified by NMR spectroscopy. Triterpenes 1, 2 and 8 were tested for cytotoxicity using the MTT assay. They did not exhibit cytotoxic effect against a human cancer cell line colon carcinoma (HCT 116).
CONCLUSIONS:
Results of the antimicrobial tests on 1, 2 and 8 indicated moderate antifungal activity against C. albicans and low antimicrobial activity against T. mentagrophytes, A. niger, S. aureus, E. coli, P. aeruginosa, and B. subtilis.
Epitaraxerol Description
Source: The herbs of Euphorbia chrysocoma
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3434 mL 11.717 mL 23.434 mL 46.868 mL 58.5851 mL
5 mM 0.4687 mL 2.3434 mL 4.6868 mL 9.3736 mL 11.717 mL
10 mM 0.2343 mL 1.1717 mL 2.3434 mL 4.6868 mL 5.8585 mL
50 mM 0.0469 mL 0.2343 mL 0.4687 mL 0.9374 mL 1.1717 mL
100 mM 0.0234 mL 0.1172 mL 0.2343 mL 0.4687 mL 0.5859 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Zhong Yao Cai. 2009 Sep;32(9):1390-2.
Studies on the chemical constituents from Euphorbia chrysocoma[Pubmed: 20034213]
To study the chemical constituents from the aerial part of Euphorbia chrysocoma.
METHODS AND RESULTS:
All compounds were isolated and purified by many methods, including siliga gel and reversed phase RP-18 column chromatographies, preparative thin layer chromatography, Sephadex LH-20, and recrystallization. Their structures were mainly elucidated by ESI-MS and NMR spectra and their physical characters. Six compounds were isolated from the petroleum ether section from 75% ethanol extraction of the material. Their structures were identified as taraxerol (1), Epitaraxerol (2), beta-sistosterol (3), beta-sitostenone (4), jolkinolide E (5), and sesamin (6).
CONCLUSIONS:
Compounds 1, 2, 4, 5, and 6 are isolated from this plant for the first time.
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