Ethyl 2,4,6-trihydroxybenzoate | CAS:90536-74-6

Ethyl 2,4,6-trihydroxybenzoate

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Description:

Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing lipid accumulation in HepG2 cells. It suppresses cellular cholesterol accumulation in a dose-dependent manner and induces the transcriptional activation of LXR-α/-β-responsive genes.

Targets:

Liver X Receptor

In vitro:

Asian Journal of Chemistry, 2005 , 17 (4) :2353-2358.

Antimicrobial guided phytochemical evaluation of the pods of Caesalpinia pulcherrima[Reference: WebLink]

METHODS AND RESULTS:
The alcoholic extract of the pods of the plant C. pulcherrima afforded five antimicrobial compounds: four homoisoflavonids (4-O-methylsappanol, protosappanin A, brazilin and caesalpin J) and Ethyl 2,4,6-trihydroxybenzoate. The structures of the compounds were established by means of NMR spectroscopic analysis. Antimicrobial activity of the compounds was evaluated against pathogenic gram -ve and gram +ve bacteria and fungi.

Ethyl 2,4,6-trihydroxybenzoate Description

Source:	The herbs of Celtis biondii
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Bioorg Med Chem Lett. 2012 Jun 15;22(12):4094-9.

Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells.[Pubmed: 22579484 ]

METHODS AND RESULTS:
The present study reports a novel liver X receptor (LXR) activator, Ethyl 2,4,6-trihydroxybenzoate (ETB), isolated from Celtis biondii. In macrophages, hepatocytes, and intestinal cells, Ethyl 2,4,6-trihydroxybenzoate suppressed cellular cholesterol accumulation in a dose-dependent manner and induced the transcriptional activation of LXR-α/-β-responsive genes. Notably, Ethyl 2,4,6-trihydroxybenzoate did not induce lipogenic gene expression or cellular triglyceride accumulation in hepatocytes.
CONCLUSIONS:
These results suggest that Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing lipid accumulation in HepG2 cells.

Product Name	Ethyl 2,4,6-trihydroxybenzoate
Price:
CAS No.:	90536-74-6
Catalog No.:	CFN96091
Molecular Formula:	C₉H₁₀O₅
Molecular Weight:	198.2 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The herbs of Celtis biondii
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-lipid metabolism abnormalities Compound Library Phenols Compound Library Liver X Receptor Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.0454 mL	25.227 mL	50.4541 mL	100.9082 mL	126.1352 mL
5 mM	1.0091 mL	5.0454 mL	10.0908 mL	20.1816 mL	25.227 mL
10 mM	0.5045 mL	2.5227 mL	5.0454 mL	10.0908 mL	12.6135 mL
50 mM	0.1009 mL	0.5045 mL	1.0091 mL	2.0182 mL	2.5227 mL
100 mM	0.0505 mL	0.2523 mL	0.5045 mL	1.0091 mL	1.2614 mL

CFN98549	Methyl salicylate	119-36-8	152.15	C₈H₈O₃
CFN92655	Methyl 2,6-dihydroxybenzoate	2150-45-0	168.2	C₈H₈O₄
CFN99087	6-(beta-D-glucopyranosyloxy)-Salicylic acid methyl ester	108124-75-0	330.3	C₁₄H₁₈O₉
CFN99607	2,6-Dimethoxybenzoic acid	1466-76-8	182.2	C₉H₁₀O₄
CFN92793	Benzyl 2,6-dimethoxybenzoate	34328-54-6	272.3	C₁₆H₁₆O₄
CFN96486	Methyl 2,4-dihydroxyphenylacetate	67828-42-6	182.17	C₉H₁₀O₄
CFN98488	2',4'-Dihydroxy-6'-methoxyacetophenone	3602-54-8	182.2	C₉H₁₀O₄
CFN96091	Ethyl 2,4,6-trihydroxybenzoate	90536-74-6	198.2	C₉H₁₀O₅