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Eupaglehnin C
Eupaglehnin C
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Eupaglehnin C
Price:
CAS No.: 476630-49-6
Catalog No.: CFN96816
Molecular Formula: C20H26O5
Molecular Weight: 346.42 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Oil
Source: The herbs of Eupatorium glehni.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Eupaglehnin C shows cytotoxic (2.19 mg/ml) against HeLa-S3.
In vitro:
Chem Pharm Bull (Tokyo). 2002 Sep;50(9):1250-4.
Seven germacranolides, eupaglehnins A, B, C, D, E, and F, and 2alpha-acetoxyepitulipinolide from Eupatorium glehni.[Reference: WebLink]
We have been interested in biologically active terpenoids from Compositae9—14) and collected E. glehni6—8) in Tokushima and Hokkaido, Japan.
METHODS AND RESULTS:
From the ethyl acetate-soluble fraction of the methanol extract, we have found four new germacranolides with unsaturated esters at the 8-position, eupaglehnin A, eupaglehnin B, Eupaglehnin C, and eupaglehnin D, and two new chlorine atom-containing germacranolides, eupaglehnin E (5) and eupaglehnin F (6),13) as well as 2a-acetoxyepitulipinolide (7) for the first time from natural sources. In our attempt to find cytotoxic compounds, eupatoriopicrin (8) 24—29) was the most effective (1.40 mg/ml), followed by Eupaglehnin C (3) (2.19 mg/ml) against HeLa-S3. However, eupaglehnin E (5) and eupaglehnin F (6) did not show cytotoxic activity, which is understandable because they had no exomethylene group.
CONCLUSIONS:
In preliminary experiments, eupatoriopicrin (8) 24—26) also showed apoptotic activity against Ha-60 cell lines, the details of which will be published in due course.
Eupaglehnin C Description
Source: The herbs of Eupatorium glehni.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
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IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8867 mL 14.4333 mL 28.8667 mL 57.7334 mL 72.1667 mL
5 mM 0.5773 mL 2.8867 mL 5.7733 mL 11.5467 mL 14.4333 mL
10 mM 0.2887 mL 1.4433 mL 2.8867 mL 5.7733 mL 7.2167 mL
50 mM 0.0577 mL 0.2887 mL 0.5773 mL 1.1547 mL 1.4433 mL
100 mM 0.0289 mL 0.1443 mL 0.2887 mL 0.5773 mL 0.7217 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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CAS No: 642-18-2
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Moschamine

Catalog No: CFN94006
CAS No: 68573-23-9
Price: $218/5mg
10-Gingerol

Catalog No: CFN99132
CAS No: 23513-15-7
Price: $60/20mg
20(R)-Ginsenoside Rg3

Catalog No: CFN98170
CAS No: 38243-03-7
Price: $60/20mg
Dendrobine

Catalog No: CFN99133
CAS No: 2115-91-5
Price: $188/20mg
Dictamnine

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CAS No: 484-29-7
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Acacetin

Catalog No: CFN98744
CAS No: 480-44-4
Price: $30/20mg
Luteolin 7-rutinoside

Catalog No: CFN93556
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Curcumenol

Catalog No: CFN92614
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Price: $70/20mg
Valerenic acid

Catalog No: CFN70254
CAS No: 3569-10-6
Price: $ / mg
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