Evodol | CAS:22318-10-1 | Manufacturer ChemFaces

Evodol

ChemFaces products have been cited in many studies from excellent and top scientific journals

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Size /Price /Stock	10 mM * 1 mL in DMSO / $318 / In-stock
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Description:

Evodol may as an anti-inflammatory agent or lead compound, it shows inhibitory activity on nitric oxide (NO) production in lipopolysaccharide -activated RAW264.7 macrophages. Evodol and limonin possess larvicidal activity against the Asian tiger mosquitoes with LC50 values of 52.22 and 32.43 ug/ml, respectively.

Targets:

In vitro:

J Asian Nat Prod Res. 2013;15(10):1130-8.

Limonoid constituents of Euodia rutaecarpa var. bodinieri and their inhibition on NO production in lipopolysaccharide-activated RAW264.7 macrophages.[Pubmed: 23869424 ]

METHODS AND RESULTS:
A new limonoid compound, named evorubodinin (1), was isolated from the dried and nearly ripe fruits of Euodia rutaecarpa (Juss.) Benth. var. bodinieri (Dode) Huang (family Rutaceae), together with two known limonoid compounds, limonin (2) and evolimorutanin (3). The chemical structure of 1 was elucidated by spectroscopic method and single-crystal X-ray diffraction. The inhibitory effects of the isolated compounds 1-3 and the structurally related compounds Evodol (4), shihulimonin A1 (5), evodirutaenin (6), 12α-hydroxyrutaevin (7), and rutaevin (8) on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages were also assayed.
CONCLUSIONS:
All compounds 1-8 showed the inhibitory activity, in which both 7 and 8 with the uncommon 5β-H configuration more efficiently inhibited NO production. The results provided valuable information for further investigation of compounds 1-8 as anti-inflammatory agents or lead compounds.

In vivo:

Parasitol Res. 2012 Sep;111(3):991-6.

Mosquito larvicidal activity of alkaloids and limonoids derived from Evodia rutaecarpa unripe fruits against Aedes albopictus (Diptera: Culicidae).[Pubmed: 22526296]

METHODS AND RESULTS:
Bioactivity-directed chromatographic separation of chloroform extract on repeated silica gel columns led to the isolation of three alkaloids (evodiamine, rutaecarpine, and wuchuyuamide I) and two limonoids (Evodol and limonin). The structures of the constituent compounds were elucidated based on high-resolution electron impact mass spectrometry and nuclear magnetic resonance. Evodiamine, rutaecarpine, and wuchuyuamide I exhibited strong larvicidal activity against the early fourth instar larvae of A. albopictus with LC(50) values of 12.51, 17.02, and 26.16 μg/ml, respectively. Limonin and Evodol also possessed larvicidal activity against the Asian tiger mosquitoes with LC(50) values of 32.43 and 52.22 μg/ml, respectively, while the ethanol extract had a LC(50) value of 43.21 μg/ml.
CONCLUSIONS:
The results indicated that the ethanol extract of E. rutaecarpa and the five isolated constituents have a good potential as a source for natural larvicides.

Evodol Description

Source:	The fruits of Evodia rutaecarpa
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Evodol
Price:	$318 / 5mg
CAS No.:	22318-10-1
Catalog No.:	CFN98214
Molecular Formula:	C₂₆H₂₈O₉
Molecular Weight:	484.5 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The fruits of Evodia rutaecarpa
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Insecticides Compound Library Triterpenoids Compound Library NO Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.064 mL	10.3199 mL	20.6398 mL	41.2797 mL	51.5996 mL
5 mM	0.4128 mL	2.064 mL	4.128 mL	8.2559 mL	10.3199 mL
10 mM	0.2064 mL	1.032 mL	2.064 mL	4.128 mL	5.16 mL
50 mM	0.0413 mL	0.2064 mL	0.4128 mL	0.8256 mL	1.032 mL
100 mM	0.0206 mL	0.1032 mL	0.2064 mL	0.4128 mL	0.516 mL

CFN97565	Limonexic acid	99026-99-0	502.5	C₂₆H₃₀O₁₀
CFN96839	Isolimonexic acid	73904-93-5	502.51	C₂₆H₃₀O₁₀
CFN97564	Limonol	989-61-7	472.5	C₂₆H₃₂O₈
CFN99280	Limonin	1180-71-8	470.5	C₂₆H₃₀O₈
CFN99256	Glaucin B	115458-73-6	528.6	C₂₈H₃₂O₁₀
CFN96685	Rutaevin	33237-37-5	486.51	C₂₆H₃₀O₉
CFN91983	Rutaevin 7-acetate	62306-81-4	528.55	C₂₈H₃₂O₁₀
CFN98214	Evodol	22318-10-1	484.5	C₂₆H₂₈O₉
CFN99328	12alpha-Hydroxyevodol	120722-04-5	500.5	C₂₆H₂₈O₁₀