Science | Nature | Cell | View More
Natural Products
Fargesone B
Fargesone B
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Fargesone B
Price:
CAS No.: 116424-70-5
Catalog No.: CFN96260
Molecular Formula: C21H24O6
Molecular Weight: 372.4 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Oil
Source: The flowers of Magnolia fargesii
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Indonesia (Indonesia)
  • Cornell University (USA)
  • University of Cincinnati (USA)
  • Texas A&M University (USA)
  • National Research Council of Ca... (Canada)
  • University of Wuerzburg (Germany)
  • Mahidol University (Thailand)
  • Universidad Veracuzana (Mexico)
  • Instytut Nawozów Sztucznych w ... (Poland)
  • Donald Danforth Plant Science C... (USA)
  • Medical University of South Car... (USA)
  • More...
Package
Featured Products
(E)-Aldosecologanin

Catalog No: CFN97737
CAS No: 471271-55-3
Price: $333/5mg
Swertisin

Catalog No: CFN90621
CAS No: 6991-10-2
Price: $228/10mg
Dendrobine

Catalog No: CFN99133
CAS No: 2115-91-5
Price: $188/20mg
Catharanthine

Catalog No: CFN99765
CAS No: 2468-21-5
Price: $40/20mg
Andrographolide

Catalog No: CFN98923
CAS No: 5508-58-7
Price: $30/20mg
Decursinol

Catalog No: CFN90496
CAS No: 23458-02-8
Price: $238/20mg
Butein

Catalog No: CFN98776
CAS No: 487-52-5
Price: $100/20mg
Hydrangenol

Catalog No: CFN98745
CAS No: 480-47-7
Price: $ /
Vanillin

Catalog No: CFN90463
CAS No: 121-33-5
Price: $30/20mg
Cnidilin

Catalog No: CFN90590
CAS No: 14348-22-2
Price: $268/10mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Fargesone B inhibits the vascular smooth muscle contraction by suppressing the voltage- and receptor-activated calcium influxes in a nonselective manner.
Targets: Calcium Channel | cAMP
In vivo:
Asia Pacif. J. Pharmacol.,1990,v.5:213-8.
Vasorelaxation of Rat Aorta by Fargesone B Isolated from the Flower buds of Magnolia Fargesii[Reference: WebLink]
The effect of Fargesone B, isolated from Magnolia fargesii, on the contraction of rat aorta was studied.
METHODS AND RESULTS:
Fargesone B suppressed the contraction of aortic rings caused by cumulative concentrations of calcium (0.03-3 mM) in high potassium (60 mM) medium, with an IC50 of 12 .mu.g ml-1. It also relaxed the norepinephrine (NE, 3 .mu.M)-induced contraction, and its pretreatment inhibited both the phasic and tonic contractions elicited by NE, with an IC50 of about 100 and 30 .mu.g ml-1, respectively. This inhibition was also observed in the absence of calcium in the medium. It did not inhibit caffeine-induced phasic contraction. In quin-2-loaded cultured vascular smooth muscle cells, Fargesone B suppressed the rise of intracellular calcium caused by NE but not that by caffeine. 45Ca++ uptake by NE was also concentration-dependently inhibited by Fargesone B. Fargesone B did not change the levels of PGI2, cGMP or cAMP of rat aorta.
CONCLUSIONS:
It is concluded that Fargesone B inhibits the vascular smooth muscle contraction by suppressing the voltage- and receptor-activated calcium influxes in a nonselective
Fargesone B Description
Source: The flowers of Magnolia fargesii
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
4,4-di(4-hydroxy-3-methoxyphenly)-...

Catalog No: CFN95200
CAS No: 913643-31-9
Price: $368/5mg
N-Demethylfordianoside

Catalog No: CFN95589
CAS No: N/A
Price: $318/10mg
Ginsenoside MC

Catalog No: CFN95232
CAS No: 175484-06-7
Price: $318/10mg
Dichotomine B

Catalog No: CFN95193
CAS No: 755036-41-0
Price: $318/5mg
New compound 4

Catalog No: CFN95185
CAS No: N/A
Price: $368/5mg
Notoptol

Catalog No: CFN95218
CAS No: 88206-49-9
Price: $318/5mg
Peucenidin

Catalog No: CFN95272
CAS No: 33044-93-8
Price: $318/5mg
Solafuranone

Catalog No: CFN95312
CAS No: 367965-50-2
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6853 mL 13.4264 mL 26.8528 mL 53.7057 mL 67.1321 mL
5 mM 0.5371 mL 2.6853 mL 5.3706 mL 10.7411 mL 13.4264 mL
10 mM 0.2685 mL 1.3426 mL 2.6853 mL 5.3706 mL 6.7132 mL
50 mM 0.0537 mL 0.2685 mL 0.5371 mL 1.0741 mL 1.3426 mL
100 mM 0.0269 mL 0.1343 mL 0.2685 mL 0.5371 mL 0.6713 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
(E)-Aldosecologanin

Catalog No: CFN97737
CAS No: 471271-55-3
Price: $333/5mg
Swertisin

Catalog No: CFN90621
CAS No: 6991-10-2
Price: $228/10mg
Dendrobine

Catalog No: CFN99133
CAS No: 2115-91-5
Price: $188/20mg
Catharanthine

Catalog No: CFN99765
CAS No: 2468-21-5
Price: $40/20mg
Andrographolide

Catalog No: CFN98923
CAS No: 5508-58-7
Price: $30/20mg
Decursinol

Catalog No: CFN90496
CAS No: 23458-02-8
Price: $238/20mg
Butein

Catalog No: CFN98776
CAS No: 487-52-5
Price: $100/20mg
Hydrangenol

Catalog No: CFN98745
CAS No: 480-47-7
Price: $ /
Vanillin

Catalog No: CFN90463
CAS No: 121-33-5
Price: $30/20mg
Cnidilin

Catalog No: CFN90590
CAS No: 14348-22-2
Price: $268/10mg
Tags: buy Fargesone B | Fargesone B supplier | purchase Fargesone B | Fargesone B cost | Fargesone B manufacturer | order Fargesone B | Fargesone B distributor