Science | Nature | Cell | View More
Natural Products
Futoquinol
Futoquinol
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Futoquinol
Price: $388 / 5mg
CAS No.: 28178-92-9
Catalog No.: CFN96249
Molecular Formula: C21H22O5
Molecular Weight: 354.4 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Oil
Source: The herbs of Piper kadsura
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $329.8 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Mysore (India)
  • University of Canterbury (New Zealand)
  • University of Zurich (Switzerland)
  • Lodz University of Technology (Poland)
  • Instituto Politécnico de Bragan?a (Portugal)
  • University of Vienna (Austria)
  • National Cancer Institute (USA)
  • Universidad Veracuzana (Mexico)
  • Wroclaw Medical University (Poland)
  • Research Unit Molecular Epigene... (Germany)
  • MTT Agrifood Research Finland (Finland)
  • More...
Package
Featured Products
Secologanic acid

Catalog No: CFN95028
CAS No: 60077-46-5
Price: $418/20mg
Coixol

Catalog No: CFN98889
CAS No: 532-91-2
Price: $40/20mg
Ginsenoside Rk3

Catalog No: CFN92593
CAS No: 364779-15-7
Price: $180/10mg
Stigmasterol glucoside

Catalog No: CFN98000
CAS No: 19716-26-8
Price: $368/5mg
Isosaponarin

Catalog No: CFN90133
CAS No: 19416-87-6
Price: $318/5mg
Jaceosidin

Catalog No: CFN90386
CAS No: 18085-97-7
Price: $168/20mg
Prim-O-glucosylcimifugin

Catalog No: CFN98104
CAS No: 80681-45-4
Price: $40/20mg
Ganoderic acid C2

Catalog No: CFN92054
CAS No: 103773-62-2
Price: $318/20mg
Rutaecarpine

Catalog No: CFN97337
CAS No: 84-26-4
Price: $40/20mg
Trachelogenin

Catalog No: CFN90598
CAS No: 34209-69-3
Price: $318/10mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Futoquinol is an anti-platelet activating factor principle from the stem part of Piper futokadsura (Piperaceae), the Chinese drug haifengteng. Futoquinol has anti-neuroinflammatory activity, it can potently inhibit NO production with an IC(50) value of 16.8 microM in microglia cells. Futoquinol shows potent inhibition of PMA-induced ROS production in human polymorphonuclear neutrophils with IC(50) values 13.1 +/- 5.3 microM.
Targets: NO | ROS | PAFR
In vitro:
Bioorg Med Chem Lett. 2010 Jan 1;20(1):409-12.
Neolignans from Piper kadsura and their anti-neuroinflammatory activity.[Pubmed: 19900811 ]

METHODS AND RESULTS:
Bioassay-guided column chromatographic separation of the methanolic extract of dried aerial parts of Piper kadsura (Piperaceae) led to the isolation of a new neolignan, piperkadsin C (1), together with eight known neolignans (2-9). The structures of the isolated compounds were elucidated by combined spectroscopic methods. The anti-neuroinflammatory activities of these compounds were evaluated by assessing nitric oxide (NO) production in LPS-activated BV-2 cells, a microglia cell line.
CONCLUSIONS:
Piperkadsin C (1) and Futoquinol (2) potently inhibited NO production with an IC(50) value of 14.6 and 16.8microM in microglia cells, respectively. Compounds 3, 4, 5, 8, and 9 also exhibited moderate inhibition of NO production in BV-2 cells.
J Nat Prod. 2006 May;69(5):842-4.
Anti-inflammatory neolignans from Piper kadsura.[Pubmed: 16724856 ]

METHODS AND RESULTS:
Two new neolignans, piperkadsin A (1) and piperkadsin B (2), as well as 11 known neolignans, three known alkaloids, the highly oxygenated compound (+)-crotepoxide, and stigmasterol were isolated from the stems of Piper kadsura. The anti-inflammatory activities of these compounds were evaluated.
CONCLUSIONS:
Compounds 1, 2, Futoquinol (3), piperlactam S (4), and N-p-coumaroyl tyramine (5) showed potent inhibition of PMA-induced ROS production in human polymorphonuclear neutrophils with IC(50) values 4.3 +/-1.0, 12.2 +/- 3.2, 13.1 +/- 5.3, 7.0 +/- 1.9, and 8.4 +/- 1.3 microM, respectively.
Futoquinol Description
Source: The herbs of Piper kadsura
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
New compound 21

Catalog No: CFN95560
CAS No: N/A
Price: $413/5mg
3',3'''-Binaringenin

Catalog No: CFN95558
CAS No: 145399-99-1
Price: $413/5mg
1-Methyl-2,8-dihydroxy-3-carboxy-9...

Catalog No: CFN95101
CAS No: 1401414-53-6
Price: $338/5mg
Neochlorogenic acid methyl ester

Catalog No: CFN95190
CAS No: 123410-65-1
Price: $198/5mg
Isosilychristin

Catalog No: CFN95369
CAS No: 77182-66-2
Price: $318/5mg
Polygalasaponin XLIX

Catalog No: CFN95117
CAS No: 1033593-12-2
Price: $318/10mg
Geoside

Catalog No: CFN95233
CAS No: 585-90-0
Price: $368/5mg
Epimedin B1

Catalog No: CFN95017
CAS No: 133137-58-3
Price: $268/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8217 mL 14.1084 mL 28.2167 mL 56.4334 mL 70.5418 mL
5 mM 0.5643 mL 2.8217 mL 5.6433 mL 11.2867 mL 14.1084 mL
10 mM 0.2822 mL 1.4108 mL 2.8217 mL 5.6433 mL 7.0542 mL
50 mM 0.0564 mL 0.2822 mL 0.5643 mL 1.1287 mL 1.4108 mL
100 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.5643 mL 0.7054 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Zhongguo Zhong Yao Za Zhi. 1993 May;18(5):292-4, 318.
Anti-platelet activating factor constituents, 2,5-diaryltetrahydrofuran type lignans, from Piper futokadsura Sied. et Zucc.[Pubmed: 8216803]

METHODS AND RESULTS:
Besides the known components kadsurenone, Futoquinol and futoxide, three anti-platelet activating factor principles have been found from the stem part of Piper futokadsura (Piperaceae), the Chinese drug haifengteng. They were separated and identified as galgravin, galbelgin and veraguensin on the basis of HPLC and spectral analysis.
CONCLUSIONS:
The natural existence of these three anti-PAF constituents in haifengteng is reported for the first time.
Secologanic acid

Catalog No: CFN95028
CAS No: 60077-46-5
Price: $418/20mg
Coixol

Catalog No: CFN98889
CAS No: 532-91-2
Price: $40/20mg
Ginsenoside Rk3

Catalog No: CFN92593
CAS No: 364779-15-7
Price: $180/10mg
Stigmasterol glucoside

Catalog No: CFN98000
CAS No: 19716-26-8
Price: $368/5mg
Isosaponarin

Catalog No: CFN90133
CAS No: 19416-87-6
Price: $318/5mg
Jaceosidin

Catalog No: CFN90386
CAS No: 18085-97-7
Price: $168/20mg
Prim-O-glucosylcimifugin

Catalog No: CFN98104
CAS No: 80681-45-4
Price: $40/20mg
Ganoderic acid C2

Catalog No: CFN92054
CAS No: 103773-62-2
Price: $318/20mg
Rutaecarpine

Catalog No: CFN97337
CAS No: 84-26-4
Price: $40/20mg
Trachelogenin

Catalog No: CFN90598
CAS No: 34209-69-3
Price: $318/10mg
Tags: buy Futoquinol | Futoquinol supplier | purchase Futoquinol | Futoquinol cost | Futoquinol manufacturer | order Futoquinol | Futoquinol distributor