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Genkwanol B
Genkwanol B
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Genkwanol B
Price:
CAS No.: 142674-67-7
Catalog No.: CFN91961
Molecular Formula: C30H22O11
Molecular Weight: 558.49 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The roots of Stellera chamaejasme
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Genkwanol B shows potent in vitro antiviral activity against respiratory syncytial virus (RSV).
Targets: RSV
In vitro:
Chin Med. 2010 Jun 21;5:23.
Antiviral biflavonoids from Radix Wikstroemiae (Liaogewanggen).[Pubmed: 20565950 ]
Radix Wikstroemiae is a common Chinese herbal medicine. The ethyl acetate fraction of the ethanolic extract of W. indica possesses potent in vitro antiviral activity against respiratory syncytial virus (RSV). This study aims to identify the antiviral components of the active fraction.
METHODS AND RESULTS:
The active fraction of the Radix Wikstroemiae extract was isolated with chromatographic methods such as silica gel, Sephadex LH-20 and semi-preparative high performance liquid chromatography (HPLC) columns. The structures of the isolated compounds were determined based on spectroscopic analyses. The in vitro antiviral activity of the compounds against RSV was tested with the cytopathic effect (CPE) reduction assay and the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. Four biflavonoids, namely neochamaejasmin B, Genkwanol B, Genkwanol C and stelleranol, were isolated and characterized. Genkwanol B, Genkwanol C and stelleranol, which are stereo isomers of spirobiflavonoids, showed potent anti-RSV activity whereas neochamaejasmin B did not.
CONCLUSIONS:
Neochamaejasmin B, Genkwanol B, Genkwanol C and stelleranol were isolated from Radix Wikstroemiae and the complete absolute configurations of five chiral carbons in stelleranol were substantiated for the first time. Furthermore, the anti-RSV activity of Genkwanol B, Genkwanol C and stelleranol was reported for the first time.
Genkwanol B Description
Source: The roots of Stellera chamaejasme
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7905 mL 8.9527 mL 17.9054 mL 35.8108 mL 44.7636 mL
5 mM 0.3581 mL 1.7905 mL 3.5811 mL 7.1622 mL 8.9527 mL
10 mM 0.1791 mL 0.8953 mL 1.7905 mL 3.5811 mL 4.4764 mL
50 mM 0.0358 mL 0.1791 mL 0.3581 mL 0.7162 mL 0.8953 mL
100 mM 0.0179 mL 0.0895 mL 0.1791 mL 0.3581 mL 0.4476 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN95554Mahuannin B82796-37-0544.5C30H24O10
CFN95579Ephedrannin A82001-39-6556.5C30H20O11
CFN95598Epiafzelechin-(2beta-O->7,4beta->8)-ent-epicatechin135820-73-4560.5C30H24O11
CFN96491Procyanidin A241743-41-3576.5C30H24O12
CFN96495Procyanidin A1103883-03-0576.5C30H24O12
CFN95547Ephedrannin D11592431-55-4592.5C30H24O13
CFN95451Dehydrodicatechin A36048-23-4576.5C30H24O12
CFN92679Dracoflavan C2194794-50-8522.6C33H30O6
CFN92680Dracoflavan C1194794-49-5522.6C33H30O6
CFN92682Dracoflavan B1194794-44-0538.6C33H30O7
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