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Glabrone
Glabrone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Glabrone
Price:
CAS No.: 60008-02-8
Catalog No.: CFN93041
Molecular Formula: C20H16O5
Molecular Weight: 336.34 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The herbs of Cudrania tricuspidata
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Glabrone shows antiviral activity against influenza virus. It also exhibits significant PPAR-gamma ligand-binding activity.
Targets: Influenza virus | PPAR
In vitro:
J Nat Prod. 2014 Mar 28;77(3):563-70.
Computer-guided approach to access the anti-influenza activity of licorice constituents.[Pubmed: 24313801]
Neuraminidase (NA), a key enzyme in viral replication, is the first-line drug target to combat influenza.
METHODS AND RESULTS:
On the basis of a shape-focused virtual screening, the roots of Glycyrrhiza glabra (licorice) were identified as plant species with an accumulation of constituents that show 3D similarities to known influenza NA inhibitors (NAIs). Phytochemical investigation revealed 12 constituents identified as (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(8-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-2-propen-1-one (1), 3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-ol (2), biochanin B (3), glabrol (4), Glabrone (5), hispaglabridin B (6), licoflavone B (7), licorice glycoside B (8), licorice glycoside E (9), liquiritigenin (10), liquiritin (11), and prunin (12). Eleven of these constituents showed significant influenza virus NA inhibition in a chemiluminescence (CL)-based assay. Additional tests, including (i) a cell-based cytopathic effect inhibition assay (general antiviral activity), (ii) the evaluation of cytotoxicity, (iii) the inhibition of the NA of Clostridium perfringens (CL- and fluorescence (FL)-based assay), and (iv) the determination of self-fluorescence and quenching, provided further perspective on their anti-influenza virus potential, revealing possible assay interference problems and false-positive results.
CONCLUSIONS:
Compounds 1, 3, 5, and 6 showed antiviral activity, most likely caused by the inhibition of NA. Of these, compounds 1, 3, and 6 were highly ranked in shape-focused virtual screening.
Bioorg Med Chem. 2010 Jan 15;18(2):962-70.
Phenolics from Glycyrrhiza glabra roots and their PPAR-gamma ligand-binding activity.[Pubmed: 20022509 ]

METHODS AND RESULTS:
Bioassay-guided fractionation of the EtOH extract of licorice (Glycyrrhiza glabra roots), using a GAL-4-PPAR-gamma chimera assay method, resulted in the isolation of 39 phenolics, including 10 new compounds (1-10). The structures of the new compounds were determined by analysis of their spectroscopic data. Among the isolated compounds, 5'-formylglabridin (5), (2R,3R)-3,4',7-trihydroxy-3'-prenylflavane (7), echinatin, (3R)-2',3',7-trihydroxy-4'-methoxyisoflavan, kanzonol X, kanzonol W, shinpterocarpin, licoflavanone A, glabrol, shinflavanone, gancaonin L, and Glabrone all exhibited significant PPAR-gamma ligand-binding activity.
CONCLUSIONS:
The activity of these compounds at a sample concentration of 10microg/mL was three times more potent than that of 0.5microM troglitazone.
Glabrone Description
Source: The herbs of Cudrania tricuspidata
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
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IF=36.216(2019)

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9732 mL 14.8659 mL 29.7318 mL 59.4636 mL 74.3295 mL
5 mM 0.5946 mL 2.9732 mL 5.9464 mL 11.8927 mL 14.8659 mL
10 mM 0.2973 mL 1.4866 mL 2.9732 mL 5.9464 mL 7.433 mL
50 mM 0.0595 mL 0.2973 mL 0.5946 mL 1.1893 mL 1.4866 mL
100 mM 0.0297 mL 0.1487 mL 0.2973 mL 0.5946 mL 0.7433 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Ginkgolic acid C15:1

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CAS No: 22910-60-7
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Alpinumisoflavone

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Jatrorrhizine

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Nothofagin

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Ganoderic acid F

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Price: $318/20mg
Neohesperidin

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Acetylshikonin

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Myricetin 3-O-galactoside

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Chrysosplenetin

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Fraxidin

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