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Gramodendrine
Gramodendrine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Gramodendrine
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CAS No.: 83905-67-3
Catalog No.: CFN00443
Molecular Formula: C21H27N3O
Molecular Weight: 337.40 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Lupinus arbustus subsp. calcaratus.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
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Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
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10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Gramodendrine and ammodendrine are moderately potent (300 mg/kg, ip) in reducing spontaneous motor activity (30% of control) and in causing central nervous system depression (50% of control). spect.
In vivo:
Journal of Agricultural & Food Chemistry, 1985,33 (5) :909-912.
Identification of toxic alkaloids from the calcaratus subspecies of Lupinus arbustus.[Reference: WebLink]
A recent chemical study of the previously uninvestigated Lupinus arbustus subspecies calcaratus resulted in the isolation and characterization of the novel bipiperidyl-indole alkaloid Gramodendrine.
METHODS AND RESULTS:
The present study describes the identification of three additional structurally diverse alkaloids from the title plant. These include the quinolizidine base lusitanine, the piperidine derivative ammodendrine, and the indole alkylamine gramine. The total alkaloid fraction as well as the first three of the above individual alkaloids were tested for gross locomotor activity and for rotorod performance in mice.
CONCLUSIONS:
Pharmacologic data indicated that Gramodendrine and ammodendrine were moderately potent (300 mg/kg, ip) in reducing spontaneous motor activity (30% of control) and in causing central nervous system depression (50% of control).
Gramodendrine Description
Source: The herbs of Lupinus arbustus subsp. calcaratus.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9638 mL 14.8192 mL 29.6384 mL 59.2768 mL 74.096 mL
5 mM 0.5928 mL 2.9638 mL 5.9277 mL 11.8554 mL 14.8192 mL
10 mM 0.2964 mL 1.4819 mL 2.9638 mL 5.9277 mL 7.4096 mL
50 mM 0.0593 mL 0.2964 mL 0.5928 mL 1.1855 mL 1.4819 mL
100 mM 0.0296 mL 0.1482 mL 0.2964 mL 0.5928 mL 0.741 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Phytochemistry,1982,21(6):1415-1417.
Gramodendrine, a bipiperidyl-indole alkaloid from Lupinus arbustus subsp. calcara tus[Reference: WebLink]

METHODS AND RESULTS:
A new bipiperidyl-indole alkaloid, Gramodendrine, was isolated from Lupinus arbustus subsp. calcaratus. Its structure was determined from spect.
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Estragole

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Price: $30/20mg
Panaxadiol

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CAS No: 19666-76-3
Price: $40/20mg
Neochlorogenic acid

Catalog No: CFN97472
CAS No: 906-33-2
Price: $90/20mg
Limonin

Catalog No: CFN99280
CAS No: 1180-71-8
Price: $40/20mg
Nuciferine

Catalog No: CFN99733
CAS No: 475-83-2
Price: $40/20mg
Isochlorogenic acid B

Catalog No: CFN99119
CAS No: 14534-61-3
Price: $50/20mg
Ganoderenic acid A

Catalog No: CFN92236
CAS No: 100665-40-5
Price: $318/10mg
Valerenic acid

Catalog No: CFN70254
CAS No: 3569-10-6
Price: $ / mg
Taurocholic acid

Catalog No: CFN96646
CAS No: 81-24-3
Price: $ / mg
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