Science | Nature | Cell | View More
Natural Products
Hederacolchiside E
Hederacolchiside E
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Hederacolchiside E
Price:
CAS No.: 33783-82-3
Catalog No.: CFN93231
Molecular Formula: C65H106O30
Molecular Weight: 1367.53 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The herbs of Pulsatilla chinensis
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS
Similar structural: Comparison
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Universiti Sains Malaysia (Malaysia)
  • China Medical University (Taiwan)
  • National Chung Hsing University (Taiwan)
  • Biotech R&D Institute (USA)
  • Chang Gung University (Taiwan)
  • Wageningen University (Netherlands)
  • Universite de Lille1 (France)
  • University of Liège (Belgium)
  • Mahidol University (Thailand)
  • Florida A&M University (USA)
  • Medizinische Universit?t Wien (Austria)
  • More...
Package
Featured Products
2-Amino-3-carboxy-1,4-naphthoquinone

Catalog No: CFN91040
CAS No: 173043-38-4
Price: $388/5mg
Alstonine

Catalog No: CFN97709
CAS No: 642-18-2
Price: $ /
Senkirkine

Catalog No: CFN00424
CAS No: 2318-18-5
Price: $ /
Gallocatechin gallate

Catalog No: CFN96488
CAS No: 5127-64-0
Price: $100/5mg
25S-Inokosterone

Catalog No: CFN93571
CAS No: 19595-18-7
Price: $318/10mg
Theaflavin 3,3'-di-O-gallate

Catalog No: CFN99130
CAS No: 30462-35-2
Price: $268/20mg
(+)-Camphor

Catalog No: CFN94889
CAS No: 464-49-3
Price: $30/20mg
Candicine

Catalog No: CFN91816
CAS No: 6656-13-9
Price: $ / mg
Phillygenin

Catalog No: CFN90511
CAS No: 487-39-8
Price: $118/20mg
Tracheloside

Catalog No: CFN90597
CAS No: 33464-71-0
Price: $50/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Hederacolchiside E has antioxidant activity, it shows inhibition on lipid peroxidation of linoleic acid emulsion; it may exert its anti-inflammatory effects by blocking bradykinin or other inflammation mediators. Hederacolchiside E shows neuroprotective effects in Alzheimer's disease (AD) models via modulating oxidative stress.
Targets: ROS | Beta Amyloid
In vitro:
Planta Med. 2004 Jun;70(6):561-3.
Antioxidant activity of saponins isolated from ivy: alpha-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F.[Pubmed: 15241892]
The antioxidant activities of alpha-hederin and hederasaponin C from Hedera helix, and Hederacolchiside E and hederacolchiside F from Hedera colchica were investigated, in this study.
METHODS AND RESULTS:
The antioxidant properties of the saponins were evaluated using different antioxidant tests: 1,1-di-phenyl-2-picryl-hydrazyl (DPPH.) free radical scavenging, total antioxidant activity, reducing power, superoxide anion radical scavenging, hydrogen peroxide scavenging, and metal chelating activities. Alpha-hederin, hederasaponin C, as well as Hederacolchiside E and hederacolchiside F exhibited a strong total antioxidant activity. At the concentration of 75 pg/mL, these saponins showed 94, 86, 88 and 75% inhibition on lipid peroxidation of linoleic acid emulsion,respectively.
CONCLUSIONS:
These various antioxidant activities were compared with model antioxidants such as a-tocopherol, butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT).
In vivo:
Eur J Med Chem. 2018 Jan 1;143:376-389.
Synthesis, biological evaluation and structure-activity relationship studies of hederacolchiside E and its derivatives as potential anti-Alzheimer agents.[Pubmed: 29202401 ]
Inspired by the previously reported neuroprotective activity of Hederacolchiside E (1), we synthesized Hederacolchiside E for the first time along with eleven of its derivatives.
METHODS AND RESULTS:
The neuroprotective effects of these compounds were further evaluated against H2O2- and Aβ1-42-induced injury using cell-based assays. The derivatives showed obvious differences in activity due to structural variations, and two of them exhibited better neuroprotective effects than 1 in the Aβ1-42-induced injury model. Compound 7 was the most active derivative and had a relatively simple chemical structure. Moreover, 1 and 7 can significantly reduce the release of lactate dehydrogenase (LDH), level of intracellular reactive oxygen species (ROS) and extent of malondialdehyde (MDA) increase resulting from Aβ1-42 treatment, which demonstrated that these kinds of compounds show neuroprotective effects in Alzheimer's disease (AD) models via modulating oxidative stress.
CONCLUSIONS:
Compound 7 could be used as promising lead for the development of a new type of neuroprotective agent against AD.
Phytomedicine. 2005 Jun;12(6-7):440-4.
Acute anti-inflammatory activity of four saponins isolated from ivy: alpha-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F in carrageenan-induced rat paw edema.[Pubmed: 16008120 ]

METHODS AND RESULTS:
The anti-inflammatory potential of alpha-hederin (monodesmoside) and hederasaponin C from Hedera helix, and Hederacolchiside E and hederacolchiside F (bidesmosides) from H. colchica was investigated in carrageenan-induced acute paw edema in rats. Saponins and indomethacin were given orally in concentrations of 0.02 and 20mg/kg body wt. For the first phase of acute inflammation, indomethacin was found as the most potent drug. Alpha-hederin and hederasaponin C were found ineffective, while Hederacolchiside E and hederacolchiside F showed slight anti-inflammatory effects on the first phase. For the second phase of acute inflammation, indomethacin and hederacolchiside F were determined as very potent compounds. alpha-hederin was found ineffective for the second phase, either. Despite hederasaponin C and Hederacolchiside E were found effective in the second phase of inflammation, they were not found as effective as indomethacin and hederacolchiside F.
CONCLUSIONS:
As a conclusion, hederasaponin C, Hederacolchiside E and hederacolchiside F, may exert their anti-inflammatory effects by blocking bradykinin or other inflammation mediators. The latter affect may occur via affecting prostaglandin pathways. Regarding the structure activity relationship, it is likely that sugars at C3 position and Rha7-Glcl-6Glc moiety at C28 position are essential for the acute anti-inflammatory effect.
Hederacolchiside E Description
Source: The herbs of Pulsatilla chinensis
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Trachelogenin 4'-O-beta-gentiobios...

Catalog No: CFN95235
CAS No: 106647-13-6
Price: $218/10mg
Oxytroflavoside A

Catalog No: CFN95463
CAS No: 1391144-80-1
Price: $318/5mg
Ganoderic acid J

Catalog No: CFN95516
CAS No: 100440-26-4
Price: $318/10mg
New compound 11

Catalog No: CFN95351
CAS No: N/A
Price: $318/10mg
Patulitrin

Catalog No: CFN95153
CAS No: 19833-25-1
Price: $318/10mg
Selaginellin

Catalog No: CFN95030
CAS No: 941269-84-7
Price: $338/5mg
Arjunglucoside I

Catalog No: CFN95049
CAS No: 62319-70-4
Price: $268/10mg
2'-Rhamnoechinacoside

Catalog No: CFN95035
CAS No: 1422390-59-7
Price: $368/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 0.7312 mL 3.6562 mL 7.3125 mL 14.6249 mL 18.2811 mL
5 mM 0.1462 mL 0.7312 mL 1.4625 mL 2.925 mL 3.6562 mL
10 mM 0.0731 mL 0.3656 mL 0.7312 mL 1.4625 mL 1.8281 mL
50 mM 0.0146 mL 0.0731 mL 0.1462 mL 0.2925 mL 0.3656 mL
100 mM 0.0073 mL 0.0366 mL 0.0731 mL 0.1462 mL 0.1828 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Pharm Biomed Anal. 2008 Dec 15;48(5):1425-9.
LC-MS/MS method for determination of hederacolchiside E, a neuroactive saponin from Pulsatilla koreana extract in rat plasma for pharmacokinetic study.[Pubmed: 18947958 ]

METHODS AND RESULTS:
A simple, rapid, and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was applied to pharmacokinetic study of a neuroactive oleanolic-glycoside saponin, Hederacolchiside E from SK-PC-B70M, a standardized extract of Pulsatilla koreana in rat. Rat plasma samples were pretreated by protein precipitation with acetonitrile, eluted from C(18) column, and analyzed using electrospray ionization (ESI)-MS/MS in negative ion mode. Digoxin was used as an internal standard. The standard curves were linear (r>0.997) over the concentration ranges of 2-500 ng/mL. The intra- and inter-day precisions were measured to be below 9% and accuracy between 90 and 111% for all quality control samples at 2, 20, 100, and 500 ng/mL (n=5). The lower limits of quantification (LLOQ) for Hederacolchiside E was 2 ng/mL and the limit of detection (LOD) 0.5 ng/mL using 20 microL of plasma sample. Subsequently, Hederacolchiside E was determined in rat plasma samples after oral administration of SK-PC-B70M. The mean maximum plasma concentrations of Hederacolchiside E were 0.07, 0.13, and 0.36 microg/mL and the mean areas under the plasma concentration versus time curve 0.56, 1.27, and 6.46 microg h/mL at doses of 100, 200, and 400 mg/kg, respectively, which indicated non-linear pharmacokinetic pattern.
CONCLUSIONS:
In conclusion, this method was successfully applied to the pharmacokinetic study of Hederacolchiside E after an oral administration of SK-PC-B70M to rats.
2-Amino-3-carboxy-1,4-naphthoquinone

Catalog No: CFN91040
CAS No: 173043-38-4
Price: $388/5mg
Alstonine

Catalog No: CFN97709
CAS No: 642-18-2
Price: $ /
Senkirkine

Catalog No: CFN00424
CAS No: 2318-18-5
Price: $ /
Gallocatechin gallate

Catalog No: CFN96488
CAS No: 5127-64-0
Price: $100/5mg
25S-Inokosterone

Catalog No: CFN93571
CAS No: 19595-18-7
Price: $318/10mg
Theaflavin 3,3'-di-O-gallate

Catalog No: CFN99130
CAS No: 30462-35-2
Price: $268/20mg
(+)-Camphor

Catalog No: CFN94889
CAS No: 464-49-3
Price: $30/20mg
Candicine

Catalog No: CFN91816
CAS No: 6656-13-9
Price: $ / mg
Phillygenin

Catalog No: CFN90511
CAS No: 487-39-8
Price: $118/20mg
Tracheloside

Catalog No: CFN90597
CAS No: 33464-71-0
Price: $50/20mg
Tags: buy Hederacolchiside E | Hederacolchiside E supplier | purchase Hederacolchiside E | Hederacolchiside E cost | Hederacolchiside E manufacturer | order Hederacolchiside E | Hederacolchiside E distributor