Science | Nature | Cell | View More
Natural Products
Histamine
Histamine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Histamine
Price: $30 / 20mg
CAS No.: 51-45-6
Catalog No.: CFN90029
Molecular Formula: C5H9N3
Molecular Weight: 111.15 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source:
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $7.0 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Indonesia (Indonesia)
  • Donald Danforth Plant Science C... (USA)
  • University of Illinois (USA)
  • Wageningen University (Netherlands)
  • Universidade da Beira Interior (Germany)
  • Medical University of Gdansk (Poland)
  • University of Canterbury (New Zealand)
  • University of Melbourne (Australia)
  • University of Sao Paulo (Brazil)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Amity University (India)
  • More...
Package
Featured Products
Brucine

Catalog No: CFN90244
CAS No: 357-57-3
Price: $30/20mg
Tanshinone IIA

Catalog No: CFN98952
CAS No: 568-72-9
Price: $30/20mg
Isosteviol

Catalog No: CFN90544
CAS No: 27975-19-5
Price: $40/20mg
24-Methylenecycloartan-3-ol

Catalog No: CFN99496
CAS No: 1449-09-8
Price: $ /
alpha-Boswellic acid

Catalog No: CFN98704
CAS No: 471-66-9
Price: $238/20mg
Velutin

Catalog No: CFN98290
CAS No: 25739-41-7
Price: $/mg
Platyconic acid A

Catalog No: CFN92268
CAS No: 68051-23-0
Price: $318/5mg
Alpinumisoflavone

Catalog No: CFN98440
CAS No: 34086-50-5
Price: $ /
Pectolinarigenin

Catalog No: CFN99010
CAS No: 520-12-7
Price: $138/20mg
Corynoxeine

Catalog No: CFN98154
CAS No: 630-94-4
Price: $148/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Histamine, an organic nitrogenous compound, is involved in local immune responses regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. It is a potent H1 and H2 receptor agonist. Histamine increases Nav1.8 expression in primary afferent neurons via H2 receptor-mediated pathway and thereby contributes to neuropathic pain, H2 receptor antagonists may potentially be used as analgesics for patients with neuropathic pain.
Targets: IL Receptor | Histamine Receptor | Nav1.8
In vivo:
Acta Microbiol Immunol Hung. 2015 Mar;62(1):87-91.
Modulation of ConA-induced inflammatory ascites by histamine - short communication.[Pubmed: 25823456]
The early phase of the ConA-induced inflammatory ascites was studied, with special reference to Histamine.
METHODS AND RESULTS:
Concanavalin A (ConA), a cell-surface binding lectin was injected i.p. (25 mg/kg bw) to mice. After 1 h the animals were killed, the ascitic fluid collected and measured. Other agents were injected s.c., 10 min before the ConA-challenge. Exogenous Histamine markedly inhibited the ConA-induced ascites. Release of endogenous vasoactive agents from the mast cells by Compound 48/80 had a similar, but slight effect. Cromolyn, a mast cell stabilizing agent, and chloropyramine, a Histamine H1 receptor antagonist was ineffective. Although Histamine increases endothelial permeability, it did not enhance the formation of ascitic fluid, on the contrary, it inhibited the ConA-induced ascites, presumably due to its known hypotonic effect.
CONCLUSIONS:
It is concluded that ConA-induced ascites is not mediated by mast cell Histamine.
Eur J Immunol. 2015 Apr;45(4):1129-40.
The histamine H4 -receptor (H4 R) regulates eosinophilic inflammation in ovalbumin-induced experimental allergic asthma in mice.[Pubmed: 25501767]
Via the Histamine H4 -receptor (H4 R), Histamine promotes the pathogenesis of experimental allergic asthma in mice. Application of H4 R antagonists during sensitization as well as during provocation reduces the severity of the disease. However, the specific cell types functionally expressing H4 R in experimental allergic asthma have not been well characterized in vivo.
METHODS AND RESULTS:
In this study, we identified the cell type(s) responsible for H4 R activity in experimental asthma and related physiological mechanisms. Using H4 R-deficient mice, we studied the role of H4 R in the sensitization and effector phase. DCs lacking H4 R expression during the in vitro sensitization reaction resulted in effector T cells unable to induce an entire eosinophilic inflammation in the lung upon adoptive transfer in vivo. Recipient mice lacking H4 R expression, which were adoptively transferred with H4 R(+/+) T cells polarized in the presence of H4 R(+/+) DCs, showed reduced signs of inflammation and ameliorated lung function. Here, we provide in vivo evidence that in experimental asthma in mice the H4 R specifically regulates activation of DCs during sensitization, while in the effector phase the H4 R is active in cells involved in the activation of eosinophils, and possibly other cells.
CONCLUSIONS:
A putative therapy targeting the H4 R may be an option for asthma patients developing IL-5-dependent eosinophilia.
Histamine Description
Source:
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Arvenin III

Catalog No: CFN95327
CAS No: 65597-45-7
Price: $318/5mg
Arganine B

Catalog No: CFN95281
CAS No: 144425-21-8
Price: $318/5mg
Dehydrojuncusol

Catalog No: CFN95143
CAS No: 117824-04-1
Price: $318/5mg
Somnifericin

Catalog No: CFN95280
CAS No: 173693-57-7
Price: $318/5mg
Mirificin-4'-O-glucoside

Catalog No: CFN95091
CAS No: 168035-01-6
Price: $288/5mg
Kakkalide

Catalog No: CFN95052
CAS No: 58274-56-9
Price: $260/10mg
(-)-Cadin-4,10(15)-dien-11-oic aci...

Catalog No: CFN95246
CAS No: 1124353-23-6
Price: $318/5mg
Epimedin B1

Catalog No: CFN95017
CAS No: 133137-58-3
Price: $268/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 8.9969 mL 44.9843 mL 89.9685 mL 179.937 mL 224.9213 mL
5 mM 1.7994 mL 8.9969 mL 17.9937 mL 35.9874 mL 44.9843 mL
10 mM 0.8997 mL 4.4984 mL 8.9969 mL 17.9937 mL 22.4921 mL
50 mM 0.1799 mL 0.8997 mL 1.7994 mL 3.5987 mL 4.4984 mL
100 mM 0.09 mL 0.4498 mL 0.8997 mL 1.7994 mL 2.2492 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Animal Research:
CNS Neurosci Ther. 2014 Oct;20(10):883-92.
Histamine upregulates Nav1.8 expression in primary afferent neurons via H2 receptors: involvement in neuropathic pain.[Pubmed: 24990156]
The upregulation of Nav1.8 in primary afferents plays a critical role in the development and persistence of neuropathic pain. The mechanisms underlying the upregulation are not fully understood.
METHODS AND RESULTS:
The present study aims to investigate the regulatory effect of Histamine on the expression of Nav1.8 in primary afferent neurons and its involvement in neuropathic pain. Histamine at 10(-8) M increased the expression of Nav1.8 in cultured DRG neurons. This effect could be blocked by H2 receptor antagonist cimetidine or famotidine, but not by H1 receptor antagonist pyrilamine or dual H3 /H4 antagonist thioperamide. Peri-sciatic administration of Histamine increased Nav1.8 expression in the sciatic nerve and L4/L5 DRG neurons in a dose-dependent manner, accompanied with remarkable mechanical allodynia and heat hyperalgesia in the ipsilateral hindpaw. Famotidine but not pyrilamine or thioperamide inhibited Nav1.8 upregulation and pain hypersensitivity. In addition, famotidine (40 mg/kg, i.p.) not only suppressed autotomy behavior in the rat neuroma model of neuropathic pain but also attenuated mechanical allodynia and thermal hyperalgesia following partial sciatic nerve ligation. Moreover, famotidine inhibited Nav1.8 upregulation in the neuroma and ligated sciatic nerve.
CONCLUSIONS:
Our findings indicate that Histamine increases Nav1.8 expression in primary afferent neurons via H2 receptor-mediated pathway and thereby contributes to neuropathic pain. H2 receptor antagonists may potentially be used as analgesics for patients with neuropathic pain.
Brucine

Catalog No: CFN90244
CAS No: 357-57-3
Price: $30/20mg
Tanshinone IIA

Catalog No: CFN98952
CAS No: 568-72-9
Price: $30/20mg
Isosteviol

Catalog No: CFN90544
CAS No: 27975-19-5
Price: $40/20mg
24-Methylenecycloartan-3-ol

Catalog No: CFN99496
CAS No: 1449-09-8
Price: $ /
alpha-Boswellic acid

Catalog No: CFN98704
CAS No: 471-66-9
Price: $238/20mg
Velutin

Catalog No: CFN98290
CAS No: 25739-41-7
Price: $/mg
Platyconic acid A

Catalog No: CFN92268
CAS No: 68051-23-0
Price: $318/5mg
Alpinumisoflavone

Catalog No: CFN98440
CAS No: 34086-50-5
Price: $ /
Pectolinarigenin

Catalog No: CFN99010
CAS No: 520-12-7
Price: $138/20mg
Corynoxeine

Catalog No: CFN98154
CAS No: 630-94-4
Price: $148/20mg
Tags: buy Histamine | Histamine supplier | purchase Histamine | Histamine cost | Histamine manufacturer | order Histamine | Histamine distributor