|Description:|| 1. l-isocorypalmine (l-ICP), l-ICP likely acts as a D1 partial agonist and a D2 antagonist to produce its in vivo effects and may be a promising agent for treatment of cocaine addiction.|
2. (-)-Isocorypalmine has significant antifungal activity.
|Targets:||cAMP | Antifection | Dopamine Receptor|
|Source:||The tubers of Corydalis yanhusuo W. T. Wang|
|Solvent:||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||2.9291 mL||14.6456 mL||29.2912 mL||58.5823 mL||73.2279 mL|
|5 mM||0.5858 mL||2.9291 mL||5.8582 mL||11.7165 mL||14.6456 mL|
|10 mM||0.2929 mL||1.4646 mL||2.9291 mL||5.8582 mL||7.3228 mL|
|50 mM||0.0586 mL||0.2929 mL||0.5858 mL||1.1716 mL||1.4646 mL|
|100 mM||0.0293 mL||0.1465 mL||0.2929 mL||0.5858 mL||0.7323 mL|
Drug Alcohol Depen., 2013, 133(2):693- 703.
|L-isocorypalmine reduces behavioral sensitization and rewarding effects of cocaine in mice by acting on dopamine receptors.[Pubmed: 24080315 ]|
|We previously reported isolation of l-Isocorypalmine (l-ICP), a mono-demethylated analog of l-tetrahydropalmatine (l-THP), from the plant Corydalis yanhusuo. Here we characterized its in vitro pharmacological properties and examined its effects on cocaine-induced behaviors in mice.Receptor binding, cAMP and [(35)S]GTPγS assays were used to examine pharmacological actions of l-ICP in vitro. Effects of l-ICP on cocaine-induced locomotor hyperactivity and sensitization and conditioned place preference (CPP) in mice were investigated. HPLC was employed to analyze metabolites of l-ICP in mouse serum.l-ICP likely acts as a D1 partial agonist and a D2 antagonist to produce its in vivo effects and may be a promising agent for treatment of cocaine addiction.|