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Isocostic acid
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Product Name Isocostic acid
Price:
CAS No.: 69978-82-1
Catalog No.: CFN97186
Molecular Formula: C15H22O2
Molecular Weight: 234.3 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Powder
Source: The roots of Aucklandia lappa Decne.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Isocostic acid may have antibacterial activity.
Targets: Antifection
In vitro:
Der Pharmacia Lettre, 2012,4 (6):1878-1882
Antibacterial Activity and Chemical Composition of Essential Oils of Inula viscosa (L.) Ait. (Asteraceae) from Constantine, Algeria[Reference: WebLink]

METHODS AND RESULTS:
The hydrodistilled essential oils of fresh aerial parts of I. viscosa (L.) Ait., collected at Ain El-Bey (Southern Constantine), was characterized by nerolidol (25.3%), Isocostic acid (10.1%), costic acid (8.0%), neo-intermedeol (6.4%) and caryophyllene oxide (5.5%), as major components. The essential oil of hydrodistilled fresh aerial parts of I. viscosa (L.) Ait., collected at Hamma-Bouziane (Northern Constantine), was mainly represented by Isocostic acid (25.1%), costic acid (15.2%), nerolidol (9.6%), linoleic acid (9.1%), neo-intermedeol (7.5%) and fokienol (7.2%). The present compositions are quite different from those reported for species growing over the world.
CONCLUSIONS:
The essential oil of the plant collected at Ain El-Bey inhibited considerably the growth of K. pneumoniae (24mm), P. aeruginosa ATCC (21mm), P. aeruginosa HS (21mm), E. coli ATCC (20mm) and E. coli HS (20mm) while the essential oil of the species growing at Hamma Bouziane exhibited a good antibacterial activity against P. aeruginosa ATCC (21mm), P. aeruginosa HS (21mm) and K. pneumoniae (20mm).
Isocostic acid Description
Source: The roots of Aucklandia lappa Decne.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.268 mL 21.3402 mL 42.6803 mL 85.3606 mL 106.7008 mL
5 mM 0.8536 mL 4.268 mL 8.5361 mL 17.0721 mL 21.3402 mL
10 mM 0.4268 mL 2.134 mL 4.268 mL 8.5361 mL 10.6701 mL
50 mM 0.0854 mL 0.4268 mL 0.8536 mL 1.7072 mL 2.134 mL
100 mM 0.0427 mL 0.2134 mL 0.4268 mL 0.8536 mL 1.067 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Tetrahedron.2015 April 1;71(13):2035–2042.
Acid-promoted opening of 4,5- and 3,4-epoxy eudesmane scaffolds from α-isocostic acid。[Reference: WebLink]

METHODS AND RESULTS:
The acid-catalyzed rearrangement of epoxide 3a and 8a derived from sesquiterpernic Isocostic acid (1), the main component of Dittrichia viscosa, was studied using Lewis and Brönsted acids. Several new compounds were obtained with different selectivities depending on the catalyst used.
CONCLUSIONS:
These compounds were fully characterized by spectroscopic methods, and mechanistic explanations for their formation are proposed.
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Price: $128/20mg
Momordicoside K

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