Isomaculosidine | CAS:518-96-7 | Manufacturer ChemFaces

Isomaculosidine

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Description:

Isomaculosidine can significantly inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells.

Targets:

In vitro:

J Enzyme Inhib Med Chem. 2012 Aug;27(4):490-4.

Inhibitory alkaloids from Dictamnus dasycarpus root barks on lipopolysaccharide-induced nitric oxide production in BV2 cells.[Pubmed: 21827366 ]

METHODS AND RESULTS:
The methanolic extract of Dictamnus dasycarpus root barks afforded one new glycosidic quinoline alkaloid, 3-[1β-hydroxy-2-(β-D-glucopyranosyloxy)-ethyl)-4-methoxy-2(1H)-quinolinone (1), together with nine known compounds, preskimmianine (2), 8-methoxy-N-methylflindersine (3), dictamine (4), γ-fagarine (5), halopine (6), skimmianine (7), dictangustine-A (8), iso-γ-fagarine (9), Isomaculosidine (10).
CONCLUSIONS:
The isolated alkaloids significantly inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells. Among them, compounds 3 and 7 showed the most potent inhibitory activities on LPS-induced NO production.

Isomaculosidine Description

Source:	The root barks of Dictamnus dasycarpus.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Isomaculosidine
Price:
CAS No.:	518-96-7
Catalog No.:	CFN96765
Molecular Formula:	C₁₄H₁₃NO₄
Molecular Weight:	259.26 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The root barks of Dictamnus dasycarpus.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Alkaloids Compound Library NO Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.8571 mL	19.2857 mL	38.5713 mL	77.1426 mL	96.4283 mL
5 mM	0.7714 mL	3.8571 mL	7.7143 mL	15.4285 mL	19.2857 mL
10 mM	0.3857 mL	1.9286 mL	3.8571 mL	7.7143 mL	9.6428 mL
50 mM	0.0771 mL	0.3857 mL	0.7714 mL	1.5429 mL	1.9286 mL
100 mM	0.0386 mL	0.1929 mL	0.3857 mL	0.7714 mL	0.9643 mL

CFN96362	Robustine	2255-50-7	215.2	C₁₂H₉NO₃
CFN98858	gamma-Fagarine	524-15-2	229.2	C₁₃H₁₁NO₃
CFN95126	Maculosidin	522-19-0	259.3	C₁₄H₁₃NO₄
CFN96010	Haplopine	5876-17-5	245.2	C₁₃H₁₁NO₄
CFN92555	Skimmianin	83-95-4	259.3	C₁₄H₁₃NO₄
CFN98242	7-Isopentenyloxy-gamma-fagarine	23417-92-7	313.4	C₁₈H₁₉NO₄
CFN90488	Evodine	6989-38-4	329.35	C₁₈H₁₉NO₅
CFN98849	Evoxine	522-11-2	347.4	C₁₈H₂₁NO₆
CFN96762	Isodictamnine	484-74-2	199.20	C₁₂H₉NO₂
CFN96763	Isopteleine	2181-84-2	229.23	C₁₃H₁₁NO₃