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    Isoshinanolone
    Isoshinanolone
    Information
    CAS No. 39626-91-0 Price
    Catalog No.CFN91988Purity>=98%
    Molecular Weight192.21Type of CompoundQuinones
    FormulaC11H12O3Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Isoshinanolone Description
    Source: The herbs of Plumbago zeylanica
    Biological Activity or Inhibitors: 1. Isoshinanolone shows excellent toxicity with LC(50) values of 1.26 microg/mL.
    2. trans-Isoshinanolone shows cytotoxicity against MDA-MB-231 breast cancer cells.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.2026 mL 26.0132 mL 52.0264 mL 104.0529 mL 130.0661 mL
    5 mM 1.0405 mL 5.2026 mL 10.4053 mL 20.8106 mL 26.0132 mL
    10 mM 0.5203 mL 2.6013 mL 5.2026 mL 10.4053 mL 13.0066 mL
    50 mM 0.1041 mL 0.5203 mL 1.0405 mL 2.0811 mL 2.6013 mL
    100 mM 0.052 mL 0.2601 mL 0.5203 mL 1.0405 mL 1.3007 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Isoshinanolone References Information
    Citation [1]

    Diseases. 2016 Jan 15;4(1). pii: E3.

    Phytoconstituents with Radical Scavenging and Cytotoxic Activities from Diospyros shimbaensis.[Pubmed: 28933383 ]
    As part of our search for natural products having antioxidant and anticancer properties, the phytochemical investigation of Diospyros shimbaensis (Ebenaceae), a plant belonging to a genus widely used in East African traditional medicine, was carried out. From its stem and root barks the new naphthoquinone 8,8'-oxo-biplumbagin (1) was isolated along with the known tetralones trans-Isoshinanolone (2) and cis-Isoshinanolone (3), and the naphthoquinones plumbagin (4) and 3,3'-biplumbagin (5). Compounds 2, 4, and 5 showed cytotoxicity (IC50 520-82.1 μM) against MDA-MB-231 breast cancer cells. Moderate to low cytotoxicity was observed for the hexane, dichloromethane, and methanol extracts of the root bark (IC50 16.1, 29.7 and > 100 μg/mL, respectively), and for the methanol extract of the stem bark (IC50 59.6 μg/mL). The radical scavenging activity of the isolated constituents (1-5) was evaluated on the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. The applicability of the crude extracts and of the isolated constituents for controlling degenerative diseases is discussed.
    Citation [2]

    Bioorg Med Chem Lett. 2010 May 1;20(9):2974-7.

    Bioactivity-guided isolation of mosquitocidal constituents from the rhizomes of Plumbago capensis Thunb.[Pubmed: 20347303 ]
    A bioassay-guided fractionation and chemical examination of chloroform extract of Plumbago capensis roots resulted in isolation and characterization of two new napthaquinone derivatives (4, 8) along with six known compounds (1-3, 5-7). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. All the compounds were tested for their mosquito larvicidal activity against fourth instar larvae of Aedes aegypti, and compared with that of rotenone. Among the tested compounds, Isoshinanolone (3) and plumbagin (1) showed excellent toxicity with LC(50) values of 1.26 and 5.43 microg/mL. New compound (8) displayed moderate toxicity against the tested mosquito species.