Science | Nature | Cell | View More
Natural Products
Isoshinanolone
Isoshinanolone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Isoshinanolone
Price:
CAS No.: 39626-91-0
Catalog No.: CFN91988
Molecular Formula: C11H12O3
Molecular Weight: 192.21 g/mol
Purity: >=98%
Type of Compound: Quinones
Physical Desc.: Powder
Source: The herbs of Plumbago zeylanica
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Cancer Research Initatives Foun... (Malaysia)
  • Universidade do Porto (Portugal)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Kazusa DNA Research Institute (Japan)
  • Universidade Federal de Goias (... (Brazil)
  • Universite Libre de Bruxelles (Belgium)
  • Fraunhofer-Institut für Moleku... (Germany)
  • University of Amsterdam (Netherlands)
  • Yale University (USA)
  • Molecular Biology Institute of ... (Spain)
  • Universita' Degli Studi Di Cagl... (Italy)
  • More...
Package
Featured Products
Luteolin-7-O-glucoside

Catalog No: CFN98565
CAS No: 5373-11-5
Price: $60/20mg
p-Cymene

Catalog No: CFN70239
CAS No: 99-87-6
Price: $30/20mg
N-trans-caffeoyltyramine

Catalog No: CFN95265
CAS No: 103188-48-3
Price: $318/5mg
Mulberroside F

Catalog No: CFN90794
CAS No: 193483-95-3
Price: $288/10mg
Cyanidin-3-O-sambubioside chloride

Catalog No: CFN92173
CAS No: 33012-73-6
Price: $643/10mg
Calycosin-7-O-beta-D-glucoside

Catalog No: CFN99141
CAS No: 20633-67-4
Price: $80/20mg
Mulberrin

Catalog No: CFN97085
CAS No: 62949-79-5
Price: $288/20mg
Glabridin

Catalog No: CFN99731
CAS No: 59870-68-7
Price: $30/20mg
Sinapic acid

Catalog No: CFN92631
CAS No: 530-59-6
Price: $30/20mg
Pinocembrin 7-O-(3''-galloyl-4'',6...

Catalog No: CFN90881
CAS No: 205370-59-8
Price: $318/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Isoshinanolone shows excellent toxicity with LC(50) values of 1.26 microg/mL. trans-Isoshinanolone shows cytotoxicity against MDA-MB-231 breast cancer cells.
In vitro:
Bioorg Med Chem Lett. 2010 May 1;20(9):2974-7.
Bioactivity-guided isolation of mosquitocidal constituents from the rhizomes of Plumbago capensis Thunb.[Pubmed: 20347303 ]

METHODS AND RESULTS:
A bioassay-guided fractionation and chemical examination of chloroform extract of Plumbago capensis roots resulted in isolation and characterization of two new napthaquinone derivatives (4, 8) along with six known compounds (1-3, 5-7). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 1D and 2D NMR) data analysis and by comparison with the literature data. All the compounds were tested for their mosquito larvicidal activity against fourth instar larvae of Aedes aegypti, and compared with that of rotenone.
CONCLUSIONS:
Among the tested compounds, Isoshinanolone (3) and plumbagin (1) showed excellent toxicity with LC(50) values of 1.26 and 5.43 microg/mL. New compound (8) displayed moderate toxicity against the tested mosquito species.
Isoshinanolone Description
Source: The herbs of Plumbago zeylanica
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
5,6,7,3',4'-Pentamethoxyflavanone

Catalog No: CFN95394
CAS No: 104193-93-3
Price: $318/5mg
Ganoderenic acid K

Catalog No: CFN95469
CAS No: 942950-94-9
Price: $318/10mg
Toddalolactone 3'-O-methyl ether (...

Catalog No: CFN95372
CAS No: 143614-35-1
Price: $318/10mg
Ginsenoside Rd2 (Quinquenoside L10...

Catalog No: CFN95231
CAS No: 83480-64-2
Price: $318/10mg
Corymboside

Catalog No: CFN95292
CAS No: 73543-87-0
Price: $318/10mg
3-O-[5'''-O-feruloyl-beta-D-apiofu...

Catalog No: CFN95154
CAS No: 148210-00-8
Price: $413/5mg
9-Hydroxy-O-senecioyl-8,9-dihydroo...

Catalog No: CFN95274
CAS No: 31456-63-0
Price: $318/5mg
Quasipanaxatriol

Catalog No: CFN95248
CAS No: 171903-78-9
Price: $413/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.2026 mL 26.0132 mL 52.0264 mL 104.0529 mL 130.0661 mL
5 mM 1.0405 mL 5.2026 mL 10.4053 mL 20.8106 mL 26.0132 mL
10 mM 0.5203 mL 2.6013 mL 5.2026 mL 10.4053 mL 13.0066 mL
50 mM 0.1041 mL 0.5203 mL 1.0405 mL 2.0811 mL 2.6013 mL
100 mM 0.052 mL 0.2601 mL 0.5203 mL 1.0405 mL 1.3007 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Diseases. 2016 Jan 15;4(1). pii: E3.
Phytoconstituents with Radical Scavenging and Cytotoxic Activities from Diospyros shimbaensis.[Pubmed: 28933383 ]
As part of our search for natural products having antioxidant and anticancer properties, the phytochemical investigation of Diospyros shimbaensis (Ebenaceae), a plant belonging to a genus widely used in East African traditional medicine, was carried out.
METHODS AND RESULTS:
From its stem and root barks the new naphthoquinone 8,8'-oxo-biplumbagin (1) was isolated along with the known tetralones trans-Isoshinanolone (2) and cis-Isoshinanolone (3), and the naphthoquinones plumbagin (4) and 3,3'-biplumbagin (5). Compounds 2, 4, and 5 showed cytotoxicity (IC50 520-82.1 μM) against MDA-MB-231 breast cancer cells. Moderate to low cytotoxicity was observed for the hexane, dichloromethane, and methanol extracts of the root bark (IC50 16.1, 29.7 and > 100 μg/mL, respectively), and for the methanol extract of the stem bark (IC50 59.6 μg/mL).
CONCLUSIONS:
The radical scavenging activity of the isolated constituents (1-5) was evaluated on the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. The applicability of the crude extracts and of the isolated constituents for controlling degenerative diseases is discussed.
Luteolin-7-O-glucoside

Catalog No: CFN98565
CAS No: 5373-11-5
Price: $60/20mg
p-Cymene

Catalog No: CFN70239
CAS No: 99-87-6
Price: $30/20mg
N-trans-caffeoyltyramine

Catalog No: CFN95265
CAS No: 103188-48-3
Price: $318/5mg
Mulberroside F

Catalog No: CFN90794
CAS No: 193483-95-3
Price: $288/10mg
Cyanidin-3-O-sambubioside chloride

Catalog No: CFN92173
CAS No: 33012-73-6
Price: $643/10mg
Calycosin-7-O-beta-D-glucoside

Catalog No: CFN99141
CAS No: 20633-67-4
Price: $80/20mg
Mulberrin

Catalog No: CFN97085
CAS No: 62949-79-5
Price: $288/20mg
Glabridin

Catalog No: CFN99731
CAS No: 59870-68-7
Price: $30/20mg
Sinapic acid

Catalog No: CFN92631
CAS No: 530-59-6
Price: $30/20mg
Pinocembrin 7-O-(3''-galloyl-4'',6...

Catalog No: CFN90881
CAS No: 205370-59-8
Price: $318/20mg
Tags: buy Isoshinanolone | Isoshinanolone supplier | purchase Isoshinanolone | Isoshinanolone cost | Isoshinanolone manufacturer | order Isoshinanolone | Isoshinanolone distributor