Jacobine | CAS:6870-67-3 | Manufacturer ChemFaces

Jacobine

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Jacobine induces significant dose-dependent DNA-DNA interstrand cross-linking over the entire range of doses. It was catalyzed by guinea pig hepatic glutathione-S-transferase enzymes in in vitro experiments.

In vitro:

Biochemical and Biophysical Research Communications,1994,198(2):516–522.

Glutathione Conjugation with the Pyrrolizidine Alkaloid, Jacobine[Reference: WebLink]

METHODS AND RESULTS:
The reaction of glutathione with the epoxide containing pyrrolizidine alkaloid, Jacobine, was catalyzed by guinea pig hepatic glutathione-S-transferase enzymes in in vitro experiments; the rate of the reaction in the presence of rat hepatic glutathione-S-transferases did not differ from the non-enzymatic rate. Using ion-pairing liquid chromatography we were able to isolate the conjugate and obtain a daughter ion spectrum using Fast Atom Bombardment Mass Spectrometry together with Collisionally Activated Dissociation/Mass Analyzed Kinetic Energy experiments.

In vivo:

Toxicology Letters.1986,32(3):275-281.

Genotoxicity of the pyrrolizidine alkaloid jacobine in rats[Reference: WebLink]

Jacobine (JAC) is a pyrolizidine alkaloid (PA) exhibiting adverse hepatic effects similar to those induced by another PA, monocrotaline (MCT). The in vitro reaction kinetics of JAC, however, have been reported to differ quantitively from those of MCT.
METHODS AND RESULTS:
We report results of experiments to detect and characterize hepatic DNA damage resulting from in vivo administration of JAC (5–60 mg/kg i.p.) to male Sprague-Dawley rats. Hepatic nuclei were isolated and served as the source of DNA in these experiments. Alkaline elution was employed to characterize the type(s) of DNA damage induced. At 4 h post administration, JAC induced significant dose-dependent DNA-DNA interstrand cross-linking over the entire range of doses. Significant DNA-protein cross-linking was also induced by doses of 15–60 mg/kg. No DNA single-strand breaks were detected. Previous studies in this laboratory have shown MCT to induce these same types of lesions.
CONCLUSIONS:
Results from these experiments demonstrate that despite a reported difference in in vitro reaction kinetics, these compounds induce a similar spectrum of DNA damage in the target organ of a susceptible species, where the adverse effects induced are also similar, such similarities are consistent with the involvement of DNA damage in the adverse hepatic effects of PAs.

Jacobine Description

Source:	The herbs of Senecio scandens
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Jacobine
Price:
CAS No.:	6870-67-3
Catalog No.:	CFN00375
Molecular Formula:	C₁₈H₂₅NO₆
Molecular Weight:	351.40 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Senecio scandens
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Toxicity Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8458 mL	14.2288 mL	28.4576 mL	56.9152 mL	71.144 mL
5 mM	0.5692 mL	2.8458 mL	5.6915 mL	11.383 mL	14.2288 mL
10 mM	0.2846 mL	1.4229 mL	2.8458 mL	5.6915 mL	7.1144 mL
50 mM	0.0569 mL	0.2846 mL	0.5692 mL	1.1383 mL	1.4229 mL
100 mM	0.0285 mL	0.1423 mL	0.2846 mL	0.5692 mL	0.7114 mL

CFN00386	Spectabiline	520-55-8	367.40	C₁₈H₂₅NO₇
CFN00399	Parsonsine	72213-98-0	439.50	C₂₂H₃₃NO₈
CFN00400	Spiraline	77156-25-3	455.50	C₂₂H₃₃NO₉
CFN00416	Seneciocannabine	81855-31-4	365.38	C₁₈H₂₃NO₇
CFN00431	Swazine	38763-74-5	349.38	C₁₈H₂₃NO₆
CFN00437	Antibiotic PF 1018	131256-42-3	433.59	C₂₈H₃₅NO₃
CFN00362	Crosemperine	30785-56-9	367.44	C₁₉H₂₉NO₆
CFN00364	Crotalarine	53937-97-6	353.41	C₁₈H₂₇NO₆
CFN00369	Erucifoline	40158-95-0	349.38	C₁₈H₂₃NO₆
CFN00453	Erucifolin N-oxide	123864-94-8	365.4	C₁₈H₂₃NO₇