Science | Nature | Cell | View More
Natural Products
Juncusol
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Juncusol
Price: $318 / 5mg
CAS No.: 62023-90-9
Catalog No.: CFN90813
Molecular Formula: C18H18O2
Molecular Weight: 266.3 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Source: The stems of Juncus effusus L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $187.6 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Chulalongkorn University (Thailand)
  • Heinrich-Heine-University Düss... (Germany)
  • Aveiro University (Portugal)
  • Sri Ramachandra University (India)
  • Universidade da Beira Interior (Germany)
  • Calcutta University (India)
  • Kyoto University (Japan)
  • Yale University (USA)
  • Medical University of Gdansk (Poland)
  • Copenhagen University (Denmark)
  • University of Oslo (Norway)
  • More...
Package
Featured Products
Epicatechin

Catalog No: CFN98781
CAS No: 490-46-0
Price: $40/20mg
Ganoderenic acid D

Catalog No: CFN90300
CAS No: 100665-43-8
Price: $368/20mg
3-O-beta-D-Glucopyranosylplatycodi...

Catalog No: CFN90950
CAS No: 38337-25-6
Price: $268/5mg
2,3,5,4'-Tetrahydroxyl diphenyleth...

Catalog No: CFN99995
CAS No: 82373-94-2
Price: $30/20mg
Doxycycline

Catalog No: CFN90251
CAS No: 564-25-0
Price: $ /
L-Menthol

Catalog No: CFN98123
CAS No: 2216-51-5
Price: $30/20mg
Procyanidin B3

Catalog No: CFN99559
CAS No: 23567-23-9
Price: $238/10mg
(+)-Isocorynoline

Catalog No: CFN90215
CAS No: 475-67-2
Price: $138/20mg
Aerugidiol

Catalog No: CFN92621
CAS No: 116425-35-5
Price: $318/5mg
Falcarindiol

Catalog No: CFN98220
CAS No: 225110-25-8
Price: $118/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Juncusol shows anxiolytic and sedative activities, it shows anxiolytic activity at dosages of 10 mg/kg; it can induce caspase-3-mediated cytotoxicity in HT22 cells. Juncusol has anti-microbial activity, it shows significant activity against MRSA strains.
Targets: Caspase | Antifection
In vitro:
J Nat Prod. 2016 Nov 23;79(11):2814-23.
Phenanthrenes from Juncus inflexus with Antimicrobial Activity against Methicillin-Resistant Staphylococcus aureus.[Pubmed: 27808510 ]
The present study has focused on an investigation of the antibacterial effects of Juncus inflexus and the isolation and identification of its active compounds.
METHODS AND RESULTS:
Eleven phenanthrenes were isolated from a methanolic extract of the roots. Four compounds (jinflexins A-D, 1-4) are new natural products, while seven phenanthrenes [juncuenins A (5), B (6), and D (8), Juncusol (7), dehydrojuncuenins A (9) and B (11), and dehydroJuncusol (10)] were isolated for the first time from the plant. Jinflexin D (4) is a dimer with an unprecedented heptacyclic ring system. The absolute configurations of the new compounds were determined by TDDFT-ECD calculations, and their enantiomeric purity was checked by chiral HPLC analysis. Extracts of different polarity (n-hexane, dichloromethane, and ethyl acetate) were evaluated for their antimicrobial effects against methicillin-resistant Staphylococcus aureus, extended-spectrum β-lactamase (ESBL)-producing Citrobacter freundii, Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae, multiresistant Acinetobacter baumannii, and Pseudomonas aeruginosa.
CONCLUSIONS:
The MIC values of the isolated compounds were determined by a microdilution method. Jinflexin B (2), Juncusol (7), juncuenin D (8), and dehydrojuncuenin B (11) showed significant activity (MIC value range 12.5-100 μg/mL) against MRSA strains.
J Nat Med. 2015 Jul;69(3):421-6.
Chemical constituents isolated from Juncus effusus induce cytotoxicity in HT22 cells.[Pubmed: 25794817 ]

METHODS AND RESULTS:
Effususol A (1), a new 9,10-dihydrophenanthrene, has been isolated from the medullae of Juncus effusus along with ten known compounds, effusol (2), dehydroeffusol (3), Juncusol (4), dehydroJuncusol (5), juncuenin B (6), dehydrojuncuenin B (7), juncuenin D (8), luteolin (9), luteolin 5-methyl ether (10), and 4-hydroxy-2,3-dimethyl-2-nonen-4-olide (11).
CONCLUSIONS:
The structure of 1 was elucidated on the basis of spectroscopic data. 2, 4, 6, 7, and 8 have induced caspase-3-mediated cytotoxicity in HT22 cells.
In vivo:
Nat Prod Res. 2012;26(13):1234-9.
Phenanthrenes from Juncus effusus with anxiolytic and sedative activities.[Pubmed: 22017742 ]
Eight phenanthrenes, 7-carboxy-2-hydroxy-1-methyl-5-vinyl-phenanthrene (1); 2,7-dihydroxy-1-methyl-5-aldehyde-9,10-dihydrophenanthrene (2); dehydroeffusol (3); dehydroJuncusol (4); 7-carboxy-2-hydroxy-1-methyl-5-vinyl-9,10-dihydrophenanthrene (5); 8-carboxy-2-hydroxy-1-methyl-5-vinyl-9,10-dihydrophenanthrene (6); effusol (7) and Juncusol (8), were isolated from the aerial part of Juncus effusus.
METHODS AND RESULTS:
Compounds 1 and 2 were identified as new constituents. Compounds 7 and 8 showed anxiolytic and sedative activities.
Juncusol Description
Source: The stems of Juncus effusus L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Patulitrin

Catalog No: CFN95153
CAS No: 19833-25-1
Price: $318/10mg
6alpha-Hydroxydehydropachymic acid

Catalog No: CFN95412
CAS No: 176390-67-3
Price: $413/5mg
3-Oxo-alpha-ilexanolic acid

Catalog No: CFN95496
CAS No: N/A
Price: $413/5mg
Hamaudol

Catalog No: CFN95115
CAS No: 735-46-6
Price: $268/10mg
Pieceid-2''-O-gallate

Catalog No: CFN95226
CAS No: 105304-51-6
Price: $318/10mg
Glyasperin C

Catalog No: CFN95065
CAS No: 142474-53-1
Price: $333/5mg
[(1(10)E,2R,4R)]-2-Methoxy-8,12-ep...

Catalog No: CFN95198
CAS No: 75412-95-2
Price: $318/10mg
Epischisandrone

Catalog No: CFN95212
CAS No: 98619-26-2
Price: $413/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.7552 mL 18.7758 mL 37.5516 mL 75.1033 mL 93.8791 mL
5 mM 0.751 mL 3.7552 mL 7.5103 mL 15.0207 mL 18.7758 mL
10 mM 0.3755 mL 1.8776 mL 3.7552 mL 7.5103 mL 9.3879 mL
50 mM 0.0751 mL 0.3755 mL 0.751 mL 1.5021 mL 1.8776 mL
100 mM 0.0376 mL 0.1878 mL 0.3755 mL 0.751 mL 0.9388 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Animal Research:
Nat Prod Commun. 2014 Aug;9(8):1177-8.
Two new anxiolytic phenanthrenes found in the medullae of Juncus effusus.[Pubmed: 25233602]
Six phenanthrenes, 2-methoxy-7-hydroxy-1-methyl-5-vinyl phenanthrene (1), juncusin (2), dehydroeffusol (3), Juncusol (4), effusol (5), and dehydroeffusal (6), were isolated from the medullae of Juncus effusus L.
METHODS AND RESULTS:
Compounds 1 and 2 were identified as being new structures, and both of them showed anxiolytic activity at dosages of 10 and 2.5 mg/kg, respectively.
Epicatechin

Catalog No: CFN98781
CAS No: 490-46-0
Price: $40/20mg
Ganoderenic acid D

Catalog No: CFN90300
CAS No: 100665-43-8
Price: $368/20mg
3-O-beta-D-Glucopyranosylplatycodi...

Catalog No: CFN90950
CAS No: 38337-25-6
Price: $268/5mg
2,3,5,4'-Tetrahydroxyl diphenyleth...

Catalog No: CFN99995
CAS No: 82373-94-2
Price: $30/20mg
Doxycycline

Catalog No: CFN90251
CAS No: 564-25-0
Price: $ /
L-Menthol

Catalog No: CFN98123
CAS No: 2216-51-5
Price: $30/20mg
Procyanidin B3

Catalog No: CFN99559
CAS No: 23567-23-9
Price: $238/10mg
(+)-Isocorynoline

Catalog No: CFN90215
CAS No: 475-67-2
Price: $138/20mg
Aerugidiol

Catalog No: CFN92621
CAS No: 116425-35-5
Price: $318/5mg
Falcarindiol

Catalog No: CFN98220
CAS No: 225110-25-8
Price: $118/20mg
Tags: buy Juncusol | Juncusol supplier | purchase Juncusol | Juncusol cost | Juncusol manufacturer | order Juncusol | Juncusol distributor