| In vitro: |
| Chem Biodivers. 2007 May;4(5):966-72. | | Dibenzocyclooctane lignans from the stems of Kadsura induta and their antiviral effect on hepatitis B virus.[Pubmed: 17511012] |
METHODS AND RESULTS:
Two new dibenzocyclooctane lignans, kadsurindutins A (1) and B (2), were isolated from the stems of Kadsura induta, together with the known, structurally related lignans schisantherin L (3), schisantherin P (4), Kadsulignan L (5), and neokadsuranin (6). Their structures and configurations were elucidated by spectroscopic methods (UV, ORD, CD, IR, 1D- and 2D-NMR) in combination with mass-spectrometric (HR-MS) techniques.
CONCLUSIONS:
Compounds 1, 5, and 6 showed in vitro antiviral effects on hepatitis B virus. | | J Asian Nat Prod Res. 1998;1(2):125-31. | | Lignans from Kadsura angustifolia.[Pubmed: 11261213 ] |
METHODS AND RESULTS:
A new dibenzocyclooctadiene lignan named angustifolin D (1) together with four known lignans: Kadsulignan L (2), kadsulignan N (3), schisantherin P (4) and meso-dihydroguaiaretic acid (5) were isolated from the stems of Kadsura angustifolia. Their structures and stereochemistries were elucidated by spectral studies.
CONCLUSIONS:
Compounds 2 and 5 showed moderate platelet-activating factor (PAF) antagonistic activities with IC50 values of 2.6 x 10(-5) and 4.1 x 10(-5) M, respectively. |
|
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