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Kushenol K
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Product Name Kushenol K
Price:
CAS No.: 101236-49-1
Catalog No.: CFN92534
Molecular Formula: C26H32O8
Molecular Weight: 472.5 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The roots of Sophora flavescens Ait.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Kushenol K is a potent and Selective Inhibitor of cGMP Phosphodiesterase 5, it also has inhibitory effects on diacylglycerol acyltransferase (DGAT). Kushenol K shows weak antiviral activity against Herpes simplex virus types I and II.
Targets: PDE | HSV | GMP
In vitro:
J Nat Prod. 1998 Dec;61(12):1552-4.
A new prenylated flavonol from the roots of Sophora flavescens.[Pubmed: 9868163]

METHODS AND RESULTS:
A new prenylated flavonol, sophoflavescenol (1), together with five known flavonoids, kurarinol, Kushenol K, kushenol H, trifolirhizin, and kuraidin, were isolated from the roots of Sophora flavescens. The structure of 1 was determined by spectroscopic analysis.
CONCLUSIONS:
Among the five known flavonoids, kurarinol, Kushenol K, and kushenol H showed weak antiviral activity against Herpes simplex virus types I and II.
Bioorg Med Chem. 2007 May 15;15(10):3445-9.
Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens.[Pubmed: 17374486]

METHODS AND RESULTS:
The methanol extract of Sophora flavescens, which is used in traditional Chinese medicine (sophorae radix), showed potent Na(+)-glucose cotransporter (SGLT) inhibitory activity.
CONCLUSIONS:
Our search for active components identified many well-known flavonoid antioxidants: kurarinone, sophoraflavanone G, Kushenol K, and kushenol N.
Kushenol K Description
Source: The roots of Sophora flavescens Ait.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1164 mL 10.582 mL 21.164 mL 42.328 mL 52.9101 mL
5 mM 0.4233 mL 2.1164 mL 4.2328 mL 8.4656 mL 10.582 mL
10 mM 0.2116 mL 1.0582 mL 2.1164 mL 4.2328 mL 5.291 mL
50 mM 0.0423 mL 0.2116 mL 0.4233 mL 0.8466 mL 1.0582 mL
100 mM 0.0212 mL 0.1058 mL 0.2116 mL 0.4233 mL 0.5291 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6.
A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5.[Pubmed: 12161123]

METHODS AND RESULTS:
During the search for naturally occurring cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) inhibitors, it was found that the extracts from Sophora flavescens exhibit potent inhibitory activity against cGMP PDE5 prepared from rat diaphragm. Therefore, the inhibitory activities of five flavonoids, kushenol H (1), Kushenol K (2), kurarinol (3), sophoflavescenol (4) and kuraridine (5), isolated from S. flavescens were measured against cGMP PDE5 to identify potent cGMP PDE5 inhibitory constituents.
CONCLUSIONS:
Among tested compounds, sophoflavescenol (4), a C-8 prenylated flavonol, showed the most potent inhibitory activity (IC(50)=0.013 microM) against cGMP PDE5 with 31.5- and 196.2-fold selectivity over PDE3 and PDE4, respectively. Kinetic analysis revealed that sophoflavescenol was a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM.
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