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L-Glutamic acid
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name L-Glutamic acid
Price: $30 / 20mg
CAS No.: 56-86-0
Catalog No.: CFN93108
Molecular Formula: C5H9NO4
Molecular Weight: 147.1 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: From Semen Trigone.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison
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10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: L-Glutamic acid is probably an excitatory transmitter of major significance in the mammalian central nervous system. L-Glutamic acid and L-lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands.
L-Glutamic acid Description
Source: From Semen Trigone.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 6.7981 mL 33.9905 mL 67.981 mL 135.9619 mL 169.9524 mL
5 mM 1.3596 mL 6.7981 mL 13.5962 mL 27.1924 mL 33.9905 mL
10 mM 0.6798 mL 3.399 mL 6.7981 mL 13.5962 mL 16.9952 mL
50 mM 0.136 mL 0.6798 mL 1.3596 mL 2.7192 mL 3.399 mL
100 mM 0.068 mL 0.3399 mL 0.6798 mL 1.3596 mL 1.6995 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Nature, 1974 , 248 (5451) :804-5.
Spinal interneurone excitation by conformationally restricted analogues of L-glutamic acid[Reference: WebLink]
L-Glutamic acid is probably an excitatory transmitter of major significance in the mammalian central nervous system1.
METHODS AND RESULTS:
The L-Glutamic acid molecule is relatively flexible, and in an attempt to gain some insight into its possible shape(s) during activation of receptors associated with excitation of central neurones, a study was made of four conformationally restricted analogues: (±)-cis-1-aminocyclohexane-1,3-dicarboxylic acid (‘cyclo-glutamic’ acid), ibotenic acid, kainic acid and its dihydro derivative.
Bioconjug. Chem., 1999 , 10 (1) :137-40.
L-Glutamic acid and L-lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands.[Reference: WebLink]

METHODS AND RESULTS:
Bisalkylation of suitably protected L-Glutamic acid and L-lysine derivatives with tert-butyl N-(2-bromoethyl)iminodiacetate 2, followed by deprotection of the omega functional group affords N, N-bis[2-[bis[2-(1, 1-dimethylethoxy)-2-oxoethyl]amino]ethyl]-L-Glutamic acid 1-(1, 1-dimethylethyl) ester 4 and N2,N2-bis[2-[bis[2-(1, 1-dimethylethoxy)-2-oxoethyl]amino]ethyl]-L-lysine 1,1-dimethylethyl ester 7. Such compounds feature a carboxylic or an amino group, respectively, which are available for conjugation with a suitable partner via formation of an amide bond. The conjugates, which can be prepared in this way, contain a chelating subunit in which all five acetic residues of DTPA are available for the complexation of metal ions. Direct bisalkylation of glycine with 2 promptly gives N, N-bis[2-[bis[2-(1,1-dimethylethoxy)-2-oxoethyl]amino]ethyl]glycine 11.
CONCLUSIONS:
The latter allows to achieve conjugates in which the central acetic group of DTPA is selectively converted into an acetamide.
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