Malvidin-3-O-galactoside chloride | CAS:30113-37-2

Malvidin-3-O-galactoside chloride

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Description:

Malvidin-3-O-galactoside chloride has antioxidant activity.

In vitro:

Food Funct. 2015 Mar 11;6(3):772-9.

Effects of anthocyans on the expression of organic anion transporting polypeptides (SLCOs/OATPs) in primary human hepatocytes.[Pubmed: 25578040]

Anthocyans (anthocyanins and their aglycones anthocyanidins) are colorful pigments, naturally occurring in fruits. They exhibit many biological effects and have potent health benefits. Anthocyans are widely used as dietary supplements and the safety of products containing them is of great importance. To investigate whether anthocyans influence the expression of hepatic uptake transporters from the organic anion transporting polypeptide (SLCO gene/OATP protein) family, we carried out studies on primary cultures of human hepatocytes.
METHODS AND RESULTS:
The hepato-cellular accumulation of widely used drugs such as statins and some anticancer drugs is mediated by the liver-specific OATP1B1 and OATP1B3, thus any interference with expression of these particular transporters might influence therapeutic outcomes. We evaluated the effects of 21 anthocyanins and their corresponding 6 anthocyanidins on the expression levels of SLCO1B1/SLCO1B3 by RT-qPCR. Changes in OATP protein levels were confirmed by western blotting. Our data show that OATP1B1 responds differently to anthocyans compared with OATP1B3. We observed the induction of SLCO1B1 gene and OATP1B1 protein in four hepatocyte samples by the anthocyanins malvin chloride, Malvidin-3-O-galactoside chloride and cyanidin-3-O-sophoroside chloride. For SLCO1B3, a reduction in the expression levels was seen with delphin chloride and the anthocyanidin pelargonidin. Although the values varied considerably between primary hepatocyte isolates from different individuals, a mean induction of SLCO1B1 (up to 60%) and reduction of SLCO1B3 (by less than 25%) were detected.
CONCLUSIONS:
We propose that the effects of anthocyans derived from high dose dietary supplements may have to be taken into account in patients undergoing a therapy with drugs transported by OATP1B1 and OATP1B3.

Malvidin-3-O-galactoside chloride Description

Source:	The fruits of Vaccinium myrtillus
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Malvidin-3-O-galactoside chloride
Price:	$318 / 10mg
CAS No.:	30113-37-2
Catalog No.:	CFN92048
Molecular Formula:	C₂₃H₂₅ClO₁₂
Molecular Weight:	528.9 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The fruits of Vaccinium myrtillus
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Antioxidants Compound Library Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8907 mL	9.4536 mL	18.9072 mL	37.8143 mL	47.2679 mL
5 mM	0.3781 mL	1.8907 mL	3.7814 mL	7.5629 mL	9.4536 mL
10 mM	0.1891 mL	0.9454 mL	1.8907 mL	3.7814 mL	4.7268 mL
50 mM	0.0378 mL	0.1891 mL	0.3781 mL	0.7563 mL	0.9454 mL
100 mM	0.0189 mL	0.0945 mL	0.1891 mL	0.3781 mL	0.4727 mL

CFN92137	Delphinidin-3,5-O-diglucoside chloride	17670-06-3	663.0	C₂₇H₃₁O₁₇Cl
CFN91870	Delphinidin-3-O-sambubioside-5-O-glucoside chloride	36415-91-5	795.1	C₃₂H₃₉ClO₂₁
CFN92034	Peonidin chloride	134-01-0	336.7	C₁₆H₁₃ClO₆
CFN92047	Peonidin-3-O-arabinoside chloride	524943-91-7	468.8	C₂₁H₂₁ClO₁₀
CFN92045	Peonidin-3-O-galactoside chloride	28148-89-2	498.9	C₂₂H₂₃ClO₁₁
CFN92046	Peonidin-3-O-glucoside chloride	6906-39-4	498.9	C₂₂H₂₃ClO₁₁
CFN91868	Peonidin-3,5-O-diglucoside chloride	132-37-6	661.0	C₂₈H₃₃ClO₁₆

CFN99740	Cyanidin-3-O-glucoside chloride	7084-24-4	449.38	C₂₁H₂₁O₁₁
CFN92041	Cyanidin-3-O-arabinoside chloride	111613-04-8	454.8	C₂₀H₁₉ClO₁₀