Science | Nature | Cell | View More
Natural Products
Meranzin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Meranzin
Price:
CAS No.: 23971-42-8
Catalog No.: CFN98249
Molecular Formula: C15H16O4
Molecular Weight: 260.3 g/mol
Purity: >=98%
Type of Compound: Coumarins
Physical Desc.: Cryst.
Source: The peels of Citrus maxima
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • VIT University (India)
  • Amity University (India)
  • University of Lodz (Poland)
  • University of Toronto (Canada)
  • Uniwersytet Jagielloński w Kra... (Poland)
  • University of Virginia (USA)
  • Colorado State University (USA)
  • Uniwersytet Gdański (Poland)
  • Indian Institute of Science (India)
  • University of Vienna (Austria)
  • China Medical University (Taiwan)
  • More...
Package
Featured Products
Lupenone

Catalog No: CFN99681
CAS No: 1617-70-5
Price: $178/20mg
Aurantio-obtusin

Catalog No: CFN99732
CAS No: 67979-25-3
Price: $90/20mg
Myricetin

Catalog No: CFN98877
CAS No: 529-44-2
Price: $40/20mg
Angeloylgomisin H

Catalog No: CFN90710
CAS No: 66056-22-2
Price: $238/10mg
20(R)-Ginsenoside Rg3

Catalog No: CFN98170
CAS No: 38243-03-7
Price: $60/20mg
Oleic acid

Catalog No: CFN94800
CAS No: 112-80-1
Price: $30/20mg
Puerarin

Catalog No: CFN99169
CAS No: 3681-99-0
Price: $30/20mg
Trigonelline

Catalog No: CFN90225
CAS No: 535-83-1
Price: $40/20mg
Saikosaponin D

Catalog No: CFN99989
CAS No: 20874-52-6
Price: $40/20mg
Borneol

Catalog No: CFN98116
CAS No: 507-70-0
Price: $30/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Meranzin exhibits strong anti-inflammatory and analgesic activity. Meranzin hydrate can induce similar effect to Fructus Aurantii on intestinal motility and it was, at least in part, mediated by stimulation of H1 histamine receptors.
Targets: Immunology & Inflammation related
In vivo:
J Ethnopharmacol. 2011 Sep 1;137(1):205-13.
Pharmacokinetic study of the prokinetic compounds meranzin hydrate and ferulic acid following oral administration of Chaihu-Shugan-San to patients with functional dyspepsia.[Pubmed: 21605652]
The effects of Meranzin hydrate, a compound isolated from Fructus aurantii in the Chaihu-Shugan-San formula, are unclear, as the pharmacokinetics have never been studied in patients with functional dyspepsia. This study aimed to describe the pharmacokinetics of ferulic acid and merazin hydrate by evaluating the prokinetics induced by Chaihu-Shugan-San and Meranzin hydrate.
METHODS AND RESULTS:
Gastric emptying and intestinal transit were measured after oral administration of a single dose of Chaihu-Shugan-San or Meranzin hydrate in rats. The tone of rat ileum was selected as direct evidence of the prokinetic activity of Meranzin hydrate. Patients with functional dyspepsia were recruited, and Meranzin hydrate and ferulic acid were identified by ultra performance liquid chromatography with tandem mass spectrometry in the plasma of patients following a single oral administration of Chaihu-Shugan-San. The resulting pharmacokinetic properties were determined by ultra performance liquid chromatography coupled to photo diode array.In rats, single doses of Chaihu-Shugan-San (20 g/kg) and Meranzin hydrate (28 mg/kg) significantly accelerated gastric emptying and intestinal transit (Chaihu-Shugan-San: 68.9 ± 5.6% and 72.3 ± 4.7%, Meranzin hydrate: 72.9 ± 3.8% and 75.2 ± 3.1%) compared with the control (55.45 ± 3.7% and 63.51 ± 5.1%, P<0.05), showing similar results as cisapride (69.6 ± 4.8% and 71.6 ± 6.3%). Meranzin hydrate (30, 100 μmol/L) directly increased the amplitude of rat ileum compared with the control (P<0.01). The pharmacokinetics profiles of Meranzin hydrate and ferulic acid in patient plasma was fitted with a two-compartment model detected by a simple, rapid and accurate UPLC method. Time to reach peak concentration of Meranzin hydrate (0.371 mg/L) and ferulic acid (0.199 mg/L) was 23.57 min and 27.50 min, respectively. The elimination half-life and area under the concentration-time curve from t=0 to the last time of Meranzin hydrate and ferulic acid were 139.53 min and 31.445 μg min/mL and 131.27 min and 14.835 μg min/mL, respectively. The absorption constant and volume of distribution of Meranzin hydrate and ferulic acid were 0.185 ± 0.065 min(-1) and 3782.89 ± 2686.72 L/kg and 0.524 ± 0.157 min(-1) and 11713 ± 7618.68 L/kg, respectively. The experimental results of the pharmacokinetic parameters of Meranzin hydrate and ferulic acid indicate that they were absorbed and distributed rapidly.
CONCLUSIONS:
The pharmacodynamics and pharmacokinetics of prokinetic Chaihu-Shugan-San and its compounds are useful for monitoring Chaihu-Shugan-San formulas in clinical practice and for understanding therapeutic mechanisms.
Chinese Journal of Spectroscopy Laboratory,2011,28(6):2999- 3003.
Anti-Inflammation and Analgesic Activities of Coumarins Compounds from the Leaves of Murraya Exotica(L.)[Reference: WebLink]

METHODS AND RESULTS:
The coumarins compounds that possed anti-inflammation and analgesic acitivities were separated from Murraya exotica(L.).Using mice writhing test as animal model of activity trace,silica gel chromatographic column as separation means,spectroscopy as the ways to determine the structures,and mice writhing test and xylene-induced ear edema test were employed to determine the anti-inflammation and analgesic activities.Six coumarins compounds were obtained.They were osthole,phebalosin,Meranzin,umbelliferone,scopoletin,and murracarpin.
CONCLUSIONS:
Murracarpin exhibited strong anti-inflammatory and analgesic activity,which possibly related to its structure including a methoxy group at C-7,a short chain at C-8 which contained both double-bond and hydroxyl groups.
Meranzin Description
Source: The peels of Citrus maxima
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Silychristin B

Catalog No: CFN95160
CAS No: 879325-58-3
Price: $318/5mg
Pinocembrin 7-O-(4'',6''-hexahydro...

Catalog No: CFN95462
CAS No: 1825287-22-6
Price: $318/10mg
Ganolucidic acid D

Catalog No: CFN95472
CAS No: 102607-22-7
Price: $413/5mg
Cichoriin

Catalog No: CFN95196
CAS No: 531-58-8
Price: $100/20mg
Magnaldehyde B

Catalog No: CFN95075
CAS No: 92829-72-6
Price: $318/5mg
New compound 18

Catalog No: CFN95527
CAS No: N/A
Price: $413/5mg
7-O-(4-beta-D-glucopyranosyloxy-3-...

Catalog No: CFN95365
CAS No: 469899-55-6
Price: $368/5mg
Lonicerin

Catalog No: CFN95055
CAS No: 25694-72-8
Price: $168/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.8417 mL 19.2086 mL 38.4172 mL 76.8344 mL 96.043 mL
5 mM 0.7683 mL 3.8417 mL 7.6834 mL 15.3669 mL 19.2086 mL
10 mM 0.3842 mL 1.9209 mL 3.8417 mL 7.6834 mL 9.6043 mL
50 mM 0.0768 mL 0.3842 mL 0.7683 mL 1.5367 mL 1.9209 mL
100 mM 0.0384 mL 0.1921 mL 0.3842 mL 0.7683 mL 0.9604 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Lupenone

Catalog No: CFN99681
CAS No: 1617-70-5
Price: $178/20mg
Aurantio-obtusin

Catalog No: CFN99732
CAS No: 67979-25-3
Price: $90/20mg
Myricetin

Catalog No: CFN98877
CAS No: 529-44-2
Price: $40/20mg
Angeloylgomisin H

Catalog No: CFN90710
CAS No: 66056-22-2
Price: $238/10mg
20(R)-Ginsenoside Rg3

Catalog No: CFN98170
CAS No: 38243-03-7
Price: $60/20mg
Oleic acid

Catalog No: CFN94800
CAS No: 112-80-1
Price: $30/20mg
Puerarin

Catalog No: CFN99169
CAS No: 3681-99-0
Price: $30/20mg
Trigonelline

Catalog No: CFN90225
CAS No: 535-83-1
Price: $40/20mg
Saikosaponin D

Catalog No: CFN99989
CAS No: 20874-52-6
Price: $40/20mg
Borneol

Catalog No: CFN98116
CAS No: 507-70-0
Price: $30/20mg
Tags: buy Meranzin | Meranzin supplier | purchase Meranzin | Meranzin cost | Meranzin manufacturer | order Meranzin | Meranzin distributor