| Structure Identification: |
| Planta Med. 2003 Mar;69(3):258-64. | | New dihydrobenzofurans and triterpenoids from roots of Microglossa pyrifolia.[Pubmed: 12677531 ] | From the roots of Microglossa pyrifolia (Lam.) Kuntze (Asteraceae, tribe Astereae), used in East African traditional Medicine to treat a variety of ailments, seven dihydrobenzofurans and seven triterpenoids (five dammaranes and two 28- nor-oleanenes) were isolated.
METHODS AND RESULTS:
Their structures were elucidated by spectroscopic (UV, MS and NMR) means. With the exception of the tremetone derivative 1, all of the dihydrobenzofurans found in this drug possess the rare 6-acetyl-5-hydroxy substitution pattern. Dihydrobenzofurans 1 [methyl 2-(5-acetyl-2,3-dihydrobenzo[beta]furan-2-yl)propenoate(Methyl 2-(5-acetyl-2,3-dihydrobenzofuran-2-yl)propenoate)], 3 (Methyl 2-(6-acetyl-5-hydroxy-2,3-dihydrobenzofuran-2-yl)propenoate] and 7 (6-acetyl-5-hydroxy-2-(1-hydroxy-2-propenyl)-3-methoxy-2,3-dihydrobenzofuran) as well as the triterpenes 3beta-acetoxy-25-hydroxydammara-20,23-diene ( 9), 3beta-acetoxy-24-oxo-dammara-20,25-diene ( 11), 17beta-hydroxy-3,16-dioxo-28-norolean-12-ene ( 12) and 17beta-hydroxy-3,11,16-trioxo-28-norolean-12-ene ( 13) are new natural products, to the best of our knowledge. |
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