Science | Nature | Cell | View More
Natural Products
Methyl syringate
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Methyl syringate
Price: $30 / 20mg
CAS No.: 884-35-5
Catalog No.: CFN97450
Molecular Formula: C10H12O5
Molecular Weight: 212.2 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Source: The herbs of Illicium micranthum.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $8.9 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Nanjing University of Chinese M... (China)
  • Universit?t Basel (Switzerland)
  • Leibniz Institute of Plant Bioc... (Germany)
  • University of Limpopo (South Africa)
  • National Cancer Institute (USA)
  • Michigan State University (USA)
  • University of South Australia (Australia)
  • Sant Gadge Baba Amravati Univer... (India)
  • Universidade Católica Portuguesa (Portugal)
  • John Innes Centre (United Kingdom)
  • Aarhus University (Denmark)
  • More...
Package
Featured Products
Tetrahydroalstonine

Catalog No: CFN97109
CAS No: 6474-90-4
Price: $338/5mg
3,7-Di-O-methylquercetin

Catalog No: CFN96221
CAS No: 2068-02-2
Price: $/mg
1,3,6-Tri-O-galloylglucose

Catalog No: CFN95043
CAS No: 18483-17-5
Price: $318/10mg
Caffeoyl alcohol

Catalog No: CFN70348
CAS No: 3598-26-3
Price: $318/10mg
Salicylic acid

Catalog No: CFN93274
CAS No: 69-72-7
Price: $30/20mg
Tanshinone IIB

Catalog No: CFN99820
CAS No: 17397-93-2
Price: $463/5mg
L-Phenylalanine

Catalog No: CFN93152
CAS No: 63-91-2
Price: $30/20mg
(+)-Gallocatechin

Catalog No: CFN99138
CAS No: 970-73-0
Price: $138/20mg
Bergapten

Catalog No: CFN98766
CAS No: 484-20-8
Price: $40/20mg
alpha-Cyperone

Catalog No: CFN99703
CAS No: 473-08-5
Price: $100/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Methyl syringate is a specific and selective activator of hTRPA1, can regulate food intake and gastric emptying through a TRPA1-mediated pathway and, by extension, can contribute to weight suppression. Methyl syringate has a unique inhibitory activity toward aflatoxin production. Methyl syringate could be effective to suppress hypoxia-induced inflammation, it inhibits the hypoxic induction of COX-2 expression and cell invasion through TRPA1 activation.
Targets: COX | hTRPA1 | TRPA1
In vitro:
Int J Food Microbiol. 2012 Feb 15;153(3):339-44.
Isolation of methyl syringate as a specific aflatoxin production inhibitor from the essential oil of Betula alba and aflatoxin production inhibitory activities of its related compounds.[Pubmed: 22177852]
Methyl syringate was isolated from the essential oil of Betula alba as an aflatoxin production inhibitor.
METHODS AND RESULTS:
It inhibited aflatoxin production of Aspergillus parasiticus and Aspergillus flavus with IC(50) values of 0.9 and 0.8 mM, respectively, without significantly inhibiting fungal growth. Methyl syringate reduced mRNA levels of genes (aflR, pksA, and omtB) [corrected] encoding proteins required for aflatoxin biosynthesis. Methyl gallate, methyl 3,4,5-trimethoxybenzoate, and methyl 3-O-methylgallate inhibited both aflatoxin production and fungal growth of A. parasiticus and A. flavus. However, their acids and syringic acid did not inhibit aflatoxin production and growth of A. parasiticus significantly, although gallic acid inhibited aflatoxin production of A. flavus with selectivity. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity of Methyl syringate was much weaker than that of gallic acid.
CONCLUSIONS:
These results showed that Methyl syringate has a unique inhibitory activity toward aflatoxin production with a different mode of action from that of gallic acid.
Phytomedicine. 2016 Mar 15;23(3):324-9.
Methyl syringate, a TRPA1 agonist represses hypoxia-induced cyclooxygenase-2 in lung cancer cells.[Pubmed: 26969386 ]
We have previously found that Methyl syringate is a specific and selective agonist of the human transient receptor potential channel ankyrin 1 (TRPA1) and suppresses food intake and gastric emptying in imprinting control region mice. Because TRPA1 has been implicated in inflammatory responses, and inflammation and tumorigenesis are stimulated by the cyclooxygenase-2 (COX-2)/prostaglandin E2 pathway in hypoxic cancer cells. This study examined the effects of Methyl syringate on hypoxia-induced COX-2 in human distal lung epithelial A549 cells.
METHODS AND RESULTS:
The effect of the Methyl syringate on suppression of hypoxia-induced COX-2 in A549 cells were determined by Western blot and/or quantitative real-time polymerase chain reaction. The anti-invasive effect of Methyl syringate was evaluated on A549 cells using matrigel invasion assay. Methyl syringate suppressed hypoxia-induced COX-2 protein and mRNA expression and promoter activity and reduced hypoxia-induced cell migration and invasion and secretion of vascular endothelial growth factor. These effects were antagonized by a TRPA1 antagonist, implying their mediation by the TRPA1 pathway.
CONCLUSIONS:
Together, these results indicate that Methyl syringate inhibits the hypoxic induction of COX-2 expression and cell invasion through TRPA1 activation. These findings suggest that Methyl syringate could be effective to suppress hypoxia-induced inflammation and indicate an additional functional effect of Methyl syringate.
Methyl syringate Description
Source: The herbs of Illicium micranthum.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Pinocembrin 7-O-(4'',6''-hexahydro...

Catalog No: CFN95462
CAS No: 1825287-22-6
Price: $318/10mg
Bergaptol-beta-glucopyranoside

Catalog No: CFN95186
CAS No: 131623-13-7
Price: $318/10mg
Campneoside II

Catalog No: CFN95498
CAS No: 95587-86-3
Price: $318/10mg
1-Methyl-2,8-dihydroxy-3-carboxy-9...

Catalog No: CFN95101
CAS No: 1401414-53-6
Price: $338/5mg
Safflospermidine B

Catalog No: CFN95254
CAS No: N/A
Price: $413/5mg
Fragransin B1

Catalog No: CFN95443
CAS No: 112516-03-7
Price: $318/5mg
Dioscoreside E

Catalog No: CFN95346
CAS No: 435321-73-6
Price: $318/5mg
3'-Hydroxy-5,7,4'-trimethoxyflavon...

Catalog No: CFN95396
CAS No: 33554-52-8
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.7125 mL 23.5627 mL 47.1254 mL 94.2507 mL 117.8134 mL
5 mM 0.9425 mL 4.7125 mL 9.4251 mL 18.8501 mL 23.5627 mL
10 mM 0.4713 mL 2.3563 mL 4.7125 mL 9.4251 mL 11.7813 mL
50 mM 0.0943 mL 0.4713 mL 0.9425 mL 1.885 mL 2.3563 mL
100 mM 0.0471 mL 0.2356 mL 0.4713 mL 0.9425 mL 1.1781 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
PLoS One. 2013 Aug 21;8(8):e71603.
The TRPA1 agonist, methyl syringate suppresses food intake and gastric emptying.[Pubmed: 23990963]
Transient receptor potential channel ankryn 1 (TRPA1) expressed in the gastrointestinal tract is associated with gastric motility, gastric emptying, and food intake.
METHODS AND RESULTS:
In this study, we investigated the effects of Methyl syringate, a specific and selective TRPA1 agonist, on food intake, gastric emptying, and gut hormone levels in imprinting control region (ICR) mice. The administration of Methyl syringate suppressed cumulative food intake and gastric emptying. In addition, treatment with ruthenium red (RR), a general cation channel blocker, and HC-030031, a selective TRPA1 antagonist, inhibited Methyl syringate-induced reduction of food intake and delayed gastric emptying in ICR mice. Methyl syringate also increased plasma peptide YY (PYY) levels, but not glucagon-like peptide-1 (GLP-1) levels. The elevation in PYY was blocked by treatment with RR and HC-030031.
CONCLUSIONS:
The present findings indicate that Methyl syringate regulates food intake and gastric emptying through a TRPA1-mediated pathway and, by extension, can contribute to weight suppression.
Tetrahydroalstonine

Catalog No: CFN97109
CAS No: 6474-90-4
Price: $338/5mg
3,7-Di-O-methylquercetin

Catalog No: CFN96221
CAS No: 2068-02-2
Price: $/mg
1,3,6-Tri-O-galloylglucose

Catalog No: CFN95043
CAS No: 18483-17-5
Price: $318/10mg
Caffeoyl alcohol

Catalog No: CFN70348
CAS No: 3598-26-3
Price: $318/10mg
Salicylic acid

Catalog No: CFN93274
CAS No: 69-72-7
Price: $30/20mg
Tanshinone IIB

Catalog No: CFN99820
CAS No: 17397-93-2
Price: $463/5mg
L-Phenylalanine

Catalog No: CFN93152
CAS No: 63-91-2
Price: $30/20mg
(+)-Gallocatechin

Catalog No: CFN99138
CAS No: 970-73-0
Price: $138/20mg
Bergapten

Catalog No: CFN98766
CAS No: 484-20-8
Price: $40/20mg
alpha-Cyperone

Catalog No: CFN99703
CAS No: 473-08-5
Price: $100/20mg
Tags: buy Methyl syringate | Methyl syringate supplier | purchase Methyl syringate | Methyl syringate cost | Methyl syringate manufacturer | order Methyl syringate | Methyl syringate distributor